Large-Scale Sprouting of Cortical Connections After Peripheral Injury in Adult Macaque Monkeys

Distributions of thalamic and cortical connections were investigated in four macaque monkeys with long-standing, accidental trauma to a forelimb, to determine whether the growth of new connections plays a role in the reorganization of somatosensory cortex that occurs after major alterations in perip...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 282; no. 5391; pp. 1117 - 1121
Main Authors:	Florence, Sherre L., Taub, Hilary B., Kaas, John H.
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for the Advancement of Science 06-11-1998 American Association for the Advancement of Science The American Association for the Advancement of Science
Subjects:	Amputation Animals Arm Arm - innervation Arm Injuries - pathology Arm Injuries - physiopathology Axons Biological and medical sciences Brain Brain Mapping Development. Senescence. Regeneration. Transplantation Electrophysiology Face Face - innervation Forelimbs Fundamental and applied biological sciences. Psychology Hands Higher nervous activity Injuries Macaca Microelectrodes Monkeys Monkeys & apes Neural Pathways - physiology Neurology Neurons Neurons, Afferent - physiology Physical Disabilities Somatosensory cortex Somatosensory Cortex - pathology Somatosensory Cortex - physiopathology Sprouting Stimulation Thalamus - pathology Thalamus - physiopathology Vertebrates: nervous system and sense organs Wrist Nervous system diseases Growth Central nervous system Monkey Anatomy Somatosensory cortex Regeneration Vertebrata Somatotopy Mammalia Pain Somesthetic pathway Amputation Primates Neurological disorder Phantom limb Brain (vertebrata)
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Summary:	Distributions of thalamic and cortical connections were investigated in four macaque monkeys with long-standing, accidental trauma to a forelimb, to determine whether the growth of new connections plays a role in the reorganization of somatosensory cortex that occurs after major alterations in peripheral somatosensory inputs. In each monkey, microelectrode recordings of cortical areas 3b and 1 demonstrated massive reorganizations of the cortex related to the affected limb. Injections of tracers in area 1 of these monkeys revealed normal patterns of thalamocortical connections, but markedly expanded lateral connections in areas 3b and 1. Thus, the growth of intracortical but not thalamocortical connections could account for much of the reorganization of the sensory maps in cortex.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.282.5391.1117