Search Results - "Tatzelt, J"

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress by Bouman, L, Schlierf, A, Lutz, A K, Shan, J, Deinlein, A, Kast, J, Galehdar, Z, Palmisano, V, Patenge, N, Berg, D, Gasser, T, Augustin, R, Trümbach, D, Irrcher, I, Park, D S, Wurst, W, Kilberg, M S, Tatzelt, J, Winklhofer, K F

“…Loss of parkin function is responsible for the majority of autosomal recessive parkinsonism. Here, we show that parkin is not only a stress-protective, but…”
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Chemical chaperones interfere with the formation of scrapie prion protein by Tatzelt, J., Prusiner, S. B., Welch, W. J.

“…The fundamental event in prion diseases involves a conformational change in one or more of the alpha‐helices of the cellular prion protein (PrP(C)) as they are…”
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A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis by Schätzl, H M, Laszlo, L, Holtzman, D M, Tatzelt, J, DeArmond, S J, Weiner, R I, Mobley, W C, Prusiner, S B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The role of chaperones in Parkinson's disease and prion diseases by Winklhofer, K F, Tatzelt, J

“…The etiologies of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, polyglutamine diseases, or prion diseases may be diverse;…”
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Cationic lipopolyamines induce degradation of PrPSc in scrapie-infected mouse neuroblastoma cells by Winklhofer, K F, Tatzelt, J

“…In prion diseases the endogenous prion protein (PrPC) is converted into an abnormally folded isoform, denoted PrPSc, which represents the major component of…”
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The Structural Transition of the Prion Protein into its Pathogenic Conformation is Induced by Unmasking Hydrophobic Sites by Leffers, K.-W., Schell, J., Jansen, K., Lucassen, R., Kaimann, T., Nagel-Steger, L., Tatzelt, J., Riesner, D.

“…A series of structural intermediates in the putative pathway from the cellular prion protein PrP C to the pathogenic form PrP Sc was established by systematic…”
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Propagation of prion strains through specific conformers of the prion protein by Scott, M R, Groth, D, Tatzelt, J, Torchia, M, Tremblay, P, DeArmond, S J, Prusiner, S B

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Scrapie Prions Selectively Modify the Stress Response in Neuroblastoma Cells by Tatzelt, Jorg, Zuo, Jianru, Voellmy, Richard, Scott, Michael, Hartl, Ulrich, Prusiner, Stanley B., Welch, William J.

“…The fundamental event underlying scrapie infection seems to be a conformational change in the prion protein. To investigate proteins that might feature in the…”
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The C-terminal Globular Domain of the Prion Protein Is Necessary and Sufficient for Import into the Endoplasmic Reticulum by Heske, Johanna, Heller, Ulrich, Winklhofer, Konstanze F., Tatzelt, Jörg

“…The mammalian prion protein (PrP) is composed of an unstructured flexible N-terminal region and a C-terminal globular domain. We examined the import of PrP…”
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Pathogenic Mutations Located in the Hydrophobic Core of the Prion Protein Interfere with Folding and Attachment of the Glycosylphosphatidylinositol Anchor by Kiachopoulos, Sophia, Bracher, Andreas, Winklhofer, Konstanze F., Tatzelt, Jörg

“…Abnormal folding of the cellular prion protein (PrPC) is a key feature in prion diseases. Here we show that two pathogenic mutations linked to inherited prion…”
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A Pathogenic PrP Mutation and Doppel Interfere with Polarized Sorting of the Prion Protein by Uelhoff, Armgard, Tatzelt, Jörg, Aguzzi, Adriano, Winklhofer, Konstanze F., Haass, Christian

“…Several proteins linked to neurodegenerative diseases, such as the β-amyloid precursor protein, amyloid β-peptide, β-secretase, and tau, undergo selective…”
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Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein by Tatzelt, J, Maeda, N, Pekny, M, Yang, S L, Betsholtz, C, Eliasson, C, Cayetano, J, Camerino, A P, DeArmond, S J, Prusiner, S B

“…In the prion diseases, extensive reactive gliosis is often found to be out of proportion to the degree of apparent neuronal damage. To evaluate the role of…”
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Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system by Blochberger, T C, Cooper, C, Peretz, D, Tatzelt, J, Griffith, O H, Baldwin, M A, Prusiner, S B

“…Syrian hamster prion protein (PrPC) and a truncated Syrian hamster prion protein lacking the glycosylphosphatidylinositol (GPI) anchor C-terminal signal…”
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Fractionated Nuclear Extracts from Hamster Cells Catalyze Cell-Free Recombination at Selective Sequences Between Adenovirus DNA and a Hamster Preinsertion Site by Tatzelt, Jorg, Fechteler, Katja, Langenbach, Peter, Doerfler, Walter

“…We have explored the mechanism of adenovirus type 12 (Ad12) DNA integration because of its importance for viral oncogenesis and as an example of insertional…”
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Pathogenic mutations inactivate parkin by distinct mechanisms by Henn, Iris H., Gostner, Johanna M., Lackner, Peter, Tatzelt, Jörg, Winklhofer, Konstanze F.

“…Loss of parkin function is the major cause of autosomal recessive Parkinson's disease (ARPD). A wide variety of parkin mutations have been identified in…”
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Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones by Winklhofer, Konstanze F, Henn, Iris H, Kay-Jackson, Penelope C, Heller, Ulrich, Tatzelt, Jörg

“…Loss of parkin function is linked to autosomal recessive juvenile parkinsonism. Here we show that proteotoxic stress and short C-terminal truncations induce…”
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Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease by Gilch, S, Winklhofer, K F, Groschup, M H, Nunziante, M, Lucassen, R, Spielhaupter, C, Muranyi, W, Riesner, D, Tatzelt, J, Schätzl, H M

“…Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that…”
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Intracellular re-routing of prion protein prevents propagation of PrPSc and delays onset of prion disease by Gilch, Sabine, Winklhofer, Konstanze F., Groschup, Martin H., Nunziante, Max, Lucassen, Ralf, Spielhaupter, Christian, Muranyi, Walter, Riesner, Detlev, Tatzelt, Jörg, Schätzl, Hermann M.

“…Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrPc). We show that…”
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Structural Instability of the Prion Protein upon M205S/R Mutations Revealed by Molecular Dynamics Simulations by Hirschberger, Thomas, Stork, Martina, Schropp, Bernhard, Winklhofer, Konstanze F., Tatzelt, Jörg, Tavan, Paul

“…The point mutations M205S and M205R have been demonstrated to severely disturb the folding and maturation process of the cellular prion protein (PrP C). These…”
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Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation by Winklhofer, Konstanze F, Heske, Johanna, Heller, Ulrich, Reintjes, Anja, Muranyi, Walter, Moarefi, Ismail, Tatzelt, Jorg

“…Misfolding of the mammalian prion protein (PrP) is implicated in the pathogenesis of prion diseases. We analyzed wild type PrP in comparison with different PrP…”
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