Search Results - "Tatsuya Ioka"

Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study by UENO, Hideki, IOKA, Tatsuya, SHIMAMURA, Tomotaka, SHO, Masayuki, KITANO, Masayuki, CHENG, Ann-Lii, MIZUMOTO, Kazuhiro, CHEN, Jen-Shi, FURUSE, Junji, FUNAKOSHI, Akihiro, HATORI, Takashi, YAMAGUCHI, Taketo, IKEDA, Masafumi, EGAWA, Shinichi, SATO, Atsushi, OHASHI, Yasuo, OKUSAKA, Takuji, TANAKA, Masao, OHKAWA, Shinichi, YANAGIMOTO, Hiroaki, BOKU, Narikazu, FUKUTOMI, Akira, SUGIMORI, Kazuya, BABA, Hideo, YAMAO, Kenji

“…The present phase III study was designed to investigate the noninferiority of S-1 alone and superiority of gemcitabine plus S-1 compared with gemcitabine alone…”
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Randomized phase III study of gemcitabine, cisplatin plus S‐1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401‐ MITSUBA) by Ioka, Tatsuya, Kanai, Masashi, Kobayashi, Shogo, Sakai, Daisuke, Eguchi, Hidetoshi, Baba, Hideo, Seo, Satoru, Taketomi, Akinobu, Takayama, Tadatoshi, Yamaue, Hiroki, Takahashi, Masahiro, Sho, Masayuki, Kamei, Keiko, Fujimoto, Jiro, Toyoda, Masanori, Shimizu, Junzo, Goto, Takuma, Shindo, Yoshitaro, Yoshimura, Kenichi, Hatano, Etsuro, Nagano, Hiroaki

“…Background Gemcitabine/cisplatin (GC) combination therapy has been the standard palliative chemotherapy for patients with advanced biliary tract cancer (BTC)…”
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Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer by Takahashi, Hidenori, Ohigashi, Hiroaki, Gotoh, Kunihito, Marubashi, Shigeru, Yamada, Terumasa, Murata, Masayuki, Ioka, Tatsuya, Uehara, Hiroyuki, Yano, Masahiko, Ishikawa, Osamu

“…OBJECTIVE:To evaluate the outcome of preoperative gemcitabine-based chemoradiation therapy (CRT) for resectable and borderline resectable pancreatic cancer…”
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Phase II study of FOLFIRINOX for chemotherapy‐naïve Japanese patients with metastatic pancreatic cancer by Okusaka, Takuji, Ikeda, Masafumi, Fukutomi, Akira, Ioka, Tatsuya, Furuse, Junji, Ohkawa, Shinichi, Isayama, Hiroyuki, Boku, Narikazu

“…The FOLFIRINOX combination of chemotherapy drugs had not been fully evaluated for Japanese pancreatic cancer patients. Therefore, we carried out a phase II…”
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Current progress in perioperative chemotherapy for biliary tract cancer by Ioka, Tatsuya, Shindo, Yoshitaro, Ueno, Makoto, Nagano, Hiroaki

“…Biliary tract cancer (BTCs) is a heterogeneous malignancy divided into cholangiocarcinoma, gallbladder cancer, and ampullary cancer. Due to little or no…”
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Adjuvant and neoadjuvant therapy for biliary tract cancer: a review of clinical trials by Nara, Satoshi, Esaki, Minoru, Ban, Daisuke, Takamoto, Takeshi, Shimada, Kazuaki, Ioka, Tatsuya, Okusaka, Takuji, Ishii, Hiroshi, Furuse, Junji

“…Abstract Cancer originating in the biliary tract can be classified as bile duct cancer (cholangiocarcinoma), gallbladder cancer, or ampullary cancer. Bile duct…”
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Liposomal irinotecan with fluorouracil and leucovorin after gemcitabine-based therapy in Japanese patients with metastatic pancreatic cancer: additional safety analysis of a randomized phase 2 trial by Furuse, Junji, Ueno, Makoto, Ikeda, Masafumi, Okusaka, Takuji, Teng, Zhaoyang, Furuya, Momoko, Ioka, Tatsuya

“…Nanoliposomal irinotecan (nal-IRI) was recently authorized in Japan for unresectable pancreatic cancer after disease progression following chemotherapy…”
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Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics by Yoneyama, Toshihiro, Ohtsuki, Sumio, Honda, Kazufumi, Kobayashi, Makoto, Iwasaki, Motoki, Uchida, Yasuo, Okusaka, Takuji, Nakamori, Shoji, Shimahara, Masashi, Ueno, Takaaki, Tsuchida, Akihiko, Sata, Naohiro, Ioka, Tatsuya, Yasunami, Yohichi, Kosuge, Tomoo, Kaneda, Takashi, Kato, Takao, Yagihara, Kazuhiro, Fujita, Shigeyuki, Huang, Wilber, Yamada, Tesshi, Tachikawa, Masanori, Terasaki, Tetsuya

“…Pancreatic cancer is one of the most lethal tumors, and reliable detection of early-stage pancreatic cancer and risk diseases for pancreatic cancer is…”
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Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study by Kindler, Hedy L, Dr, Ioka, Tatsuya, MD, Richel, Dirk J, MD, Bennouna, Jaafar, MD, Létourneau, Richard, MD, Okusaka, Takuji, MD, Funakoshi, Akihiro, MD, Furuse, Junji, MD, Park, Young Suk, MD, Ohkawa, Shinichi, MD, Springett, Gregory M, MD, Wasan, Harpreet S, MB, Trask, Peter C, PhD, Bycott, Paul, PhD, Ricart, Alejandro D, MD, Kim, Sinil, MD, Van Cutsem, Eric, MD

“…Summary Background Axitinib is a potent, selective inhibitor of vascular endothelial growth factor (VEGF) receptors 1, 2, and 3. A randomised phase 2 trial of…”
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Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells by Kimura, Yuta, Tsunedomi, Ryouichi, Yoshimura, Kiyoshi, Matsukuma, Satoshi, Shindo, Yoshitaro, Matsui, Hiroto, Tokumitsu, Yukio, Yoshida, Shin, Iida, Michihisa, Suzuki, Nobuaki, Takeda, Shigeru, Ioka, Tatsuya, Hazama, Shoichi, Nagano, Hiroaki

“…Background Poor prognosis in liver cancer is due to its high frequency of intrahepatic metastasis. Cancer stem-like cells (CSLCs), which possess the properties…”
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Tolerability and efficacy of durvalumab, either as monotherapy or in combination with tremelimumab, in patients from Asia with advanced biliary tract, esophageal, or head‐and‐neck cancer by Doki, Yuichiro, Ueno, Makoto, Hsu, Chih‐Hung, Oh, Do‐Youn, Park, Keunchil, Yamamoto, Noboru, Ioka, Tatsuya, Hara, Hiroki, Hayama, Manabu, Nii, Masahiro, Komuro, Keiko, Sugimoto, Mariko, Tahara, Makoto

“…Background Agents targeting the programmed cell death‐1 pathway have demonstrated encouraging activity across multiple solid tumor types. The dose expansion…”
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Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells by Tsunedomi, Ryouichi, Yoshimura, Kiyoshi, Kimura, Yuta, Nishiyama, Mitsuo, Fujiwara, Nobuyuki, Matsukuma, Satoshi, Kanekiyo, Shinsuke, Matsui, Hiroto, Shindo, Yoshitaro, Watanabe, Yusaku, Tokumitsu, Yukio, Yoshida, Shin, Iida, Michihisa, Suzuki, Nobuaki, Takeda, Shigeru, Ioka, Tatsuya, Hazama, Shoichi, Nagano, Hiroaki

“…Cancer stem cells (CSCs) are thought to play important roles in carcinogenesis, recurrence, metastasis, and therapy-resistance. We have successfully induced…”
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Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine by Ikeda, Masafumi, Ioka, Tatsuya, Fukutomi, Akira, Morizane, Chigusa, Kasuga, Akiyoshi, Takahashi, Hideaki, Todaka, Akiko, Okusaka, Takuji, Creasy, Caretha L., Gorman, Shelby, Felitsky, Daniel J., Kobayashi, Mikiro, Zhang, Fanghong, Furuse, Junji

“…Gemcitabine‐based therapy remains the mainstay of treatment for patients with biliary tract cancers (BTCs) with no second‐line treatment(s) established yet…”
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ASO Visual Abstract: Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells by Kimura, Yuta, Tsunedomi, Ryouichi, Yoshimura, Kiyoshi, Matsukuma, Satoshi, Shindo, Yoshitaro, Matsui, Hiroto, Tokumitsu, Yukio, Yoshida, Shin, Iida, Michihisa, Suzuki, Nobuaki, Takeda, Shigeru, Ioka, Tatsuya, Hazama, Shoichi, Nagano, Hiroaki

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High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer by Furuya, Kei, Nakajima, Masao, Tsunedomi, Ryouichi, Nakagami, Yuki, Xu, Ming, Matsui, Hiroto, Tokumitsu, Yukio, Shindo, Yoshitaro, Watanabe, Yusaku, Tomochika, Shinobu, Maeda, Noriko, Iida, Michihisa, Suzuki, Nobuaki, Takeda, Shigeru, Hazama, Shoichi, Ioka, Tatsuya, Hoshii, Yoshinobu, Ueno, Tomio, Nagano, Hiroaki

“…To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic…”
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Risk of peritoneal carcinomatosis by endoscopic ultrasound-guided fine needle aspiration for pancreatic cancer by Ikezawa, Kenji, Uehara, Hiroyuki, Sakai, Arata, Fukutake, Nobuyasu, Imanaka, Kazuho, Ohkawa, Kazuyoshi, Tanakura, Rena, Ioka, Tatsuya, Tanaka, Sachiko, Ishikawa, Osamu, Katayama, Kazuhiro

“…Background Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an accurate method for cytological confirmation of pancreatic malignancy, but…”
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Molecular detection and clinicopathological characteristics of advanced/recurrent biliary tract carcinomas harboring the FGFR2 rearrangements: a prospective observational study (PRELUDE Study) by Maruki, Yuta, Morizane, Chigusa, Arai, Yasuhito, Ikeda, Masafumi, Ueno, Makoto, Ioka, Tatsuya, Naganuma, Atsushi, Furukawa, Masayuki, Mizuno, Nobumasa, Uwagawa, Tadashi, Takahara, Naminatsu, Kanai, Masashi, Asagi, Akinori, Shimizu, Satoshi, Miyamoto, Atsushi, Yukisawa, Seigo, Kadokura, Makoto, Kojima, Yasushi, Furuse, Junji, Nakajima, Takako Eguchi, Sudo, Kentaro, Kobayashi, Noritoshi, Hama, Natsuko, Yamanaka, Takeharu, Shibata, Tatsuhiro, Okusaka, Takuji

“…Background Fibroblast growth factor receptor 2 ( FGFR2 ) rearrangement is expected to be a novel therapeutic target in advanced/recurrent biliary tract cancer…”
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Effectiveness of Contrast-Enhanced Ultrasonography for the Characterization of Small and Early Stage Pancreatic Adenocarcinoma by Tanaka, Sachiko, Fukuda, Junko, Nakao, Miho, Ioka, Tatsuya, Ashida, Reiko, Takakura, Rena, Okagaki, Suetsumi, Katayama, Kazuhiro, Ohkawa, Kazuyoshi, Ikezawa, Kenji, Nagata, Shigenori

“…The purpose of this retrospective study is to evaluate the effectiveness of contrast-enhanced ultrasonography for the characterization of small and early stage…”
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Slight Dilatation of the Main Pancreatic Duct and Presence of Pancreatic Cysts as Predictive Signs of Pancreatic Cancer: A Prospective Study by TANAKA, Sachiko, NAKAO, Miho, IOKA, Tatsuya, TAKAKURA, Rena, TAKANO, Yasuna, TSUKUMA, Hideaki, UEHARA, Hiroyuki, SUZUKI, Reiko, FUKUDA, Junko

“…To prospectively determine whether slight dilatation of the main pancreatic duct and pancreatic cysts detected at ultrasonography (US) are predictive signs of…”
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Randomized phase II study of chemoradiotherapy with versus without induction chemotherapy for locally advanced pancreatic cancer: Japan Clinical Oncology Group trial, JCOG1106 by Ioka, Tatsuya, Furuse, Junji, Fukutomi, Akira, Mizusawa, Junki, Nakamura, Satoaki, Hiraoka, Nobuyoshi, Ito, Yoshinori, Katayama, Hiroshi, Ueno, Makoto, Ikeda, Masafumi, Sugimori, Kazuya, Okano, Naohiro, Shimizu, Kyoko, Yanagimoto, Hiroaki, Okusaka, Takuji, Ozaka, Masato, Todaka, Akiko, Nakamori, Shoji, Tobimatsu, Kazutoshi, Sata, Naohiro, Kawashima, Yohei, Hosokawa, Ayumu, Yamaguchi, Taketo, Miyakawa, Hiroyuki, Hara, Hiroki, Mizuno, Nobumasa, Ishii, Hiroshi

“…Abstract Background Chemoradiotherapy is a treatment option for locally advanced pancreatic cancer. However, the efficacy of induction chemotherapy prior to…”
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