Evaluation of Brain Functions in Conversion Disorder with PET/MRI
Introduction Since there is no objective criteria, unique clinical symptom or laboratory test to make the diagnosis of conversion disorder; its diagnosis and treatment is challenging which leads to a poor prognosis. Objectives The aim of this study is to investigate the brain metabolic activity of p...
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| Published in: | European psychiatry Vol. 65; no. S1; p. S220 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Paris
Cambridge University Press
01-06-2022
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Introduction
Since there is no objective criteria, unique clinical symptom or laboratory test to make the diagnosis of conversion disorder; its diagnosis and treatment is challenging which leads to a poor prognosis.
Objectives
The aim of this study is to investigate the brain metabolic activity of patients with conversion disorder with PET/MRI.
Methods
12 conversion disorder patients were included. Somatosensory Amplification Scale, Somatoform Dissociation Scale, Patient Health Questionnaire-15, Toronto Alexithymia Scale were filled in by the participants. Neurological, mental status examinations, Wechsler Adult Intelligence Scale-Revised Form (WAIS-R) and brain F18-FDG-PET/MRI were performed. Structured Clinical Interview for DSM-5, Hamilton Depression and Anxiety Scales were administered.
Results
83% of the patients were female, the mean age was 33 years and average education period was 10,2 years. WAIS-R total scores were consistent with low avarage intelligence level.Cerebral hypermetabolism was detected in the primary visual cortex. Average regional brain metabolic activity had a tendency to increase in bilateral prefrontal, right sensorimotor (SM),cingulate,right inferior parietal,occipital lateral,right temporal lateral cortices and cerebellum. Each region was metabolically correlated with the homologous contralateral regions. Significant correlations in the same direction was found between frontal and occipital lateral & primary visual cortices; cerebellum and left sensorimotor cortex; anterior cingulate cortex(ACC) and superior parietal cortex & cerebellum. No correlations were found between ACC and left SM cortex.
Conclusions
Findings of our study indicate that there are moderate changes in regional brain metabolic activities and inter-regional correlations in patients with conversion disorder. In order to confirm these findings, furter functional neuroimaging studies are needed.
Disclosure
No significant relationships. |
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| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2022.573 |