Search Results - "Tate, Melissa L. Knothe"

A spike in circulating cytokines TNF-α and TGF-β alters barrier function between vascular and musculoskeletal tissues by Ngo, Lucy, Knothe Tate, Melissa L.

“…Molecular transport between the circulatory and musculoskeletal systems regulates articular joint physiology in health and disease. Osteoarthritis (OA) is a…”
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Current insights on the regenerative potential of the periosteum: Molecular, cellular, and endogenous engineering approaches by Colnot, Céline, Zhang, Xinping, Tate, Melissa L. Knothe

“…While century old clinical reports document the periosteum's remarkable regenerative capacity, only in the past decade have scientists undertaken mechanistic…”
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Flow-induced stress on adherent cells in microfluidic devices by Shemesh, Jonathan, Jalilian, Iman, Shi, Anthony, Heng Yeoh, Guan, Knothe Tate, Melissa L, Ebrahimi Warkiani, Majid

“…Transduction of mechanical forces and chemical signals affect every cell in the human body. Fluid flow in systems such as the lymphatic or circulatory systems…”
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Concise Review: The Periosteum: Tapping into a Reservoir of Clinically Useful Progenitor Cells by Chang, Hana, Knothe Tate, Melissa L.

“…Elucidation of the periosteum and its regenerative potential has become a hot topic in orthopedics. Yet few review articles address the unique features of…”
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Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment by Putra, Vina D. L., Kilian, Kristopher A., Knothe Tate, Melissa L.

“…Across complex, multi-time and -length scale biological systems, redundancy confers robustness and resilience, enabling adaptation and increasing survival…”
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Connectomics of Bone to Brain—Probing Physical Renderings of Cellular Experience by Knothe Tate, Melissa L., Srikantha, Abhilash, Wojek, Christian, Zeidler, Dirk

“…“Brainless” cells, the living constituents inhabiting all biological materials, exhibit remarkably smart , i.e., stimuli-responsive and adaptive, behavior. The…”
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Medial meniscal displacement and strain in three dimensions under compressive loads: MR assessment by Freutel, Maren, Seitz, Andreas M., Galbusera, Fabio, Bornstedt, Axel, Rasche, Volker, Knothe Tate, Melissa L., Ignatius, Anita, Dürselen, Lutz

“…Purpose To investigate the 3D displacement and the local strain of the medial meniscus and its attachments under compressive loading. Materials and Methods…”
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Idealization of pericellular fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on osteocytes by Anderson, Eric J, Knothe Tate, Melissa L

“…Abstract To date, no published study has examined quantitatively the effect of geometric and dimensional idealization on prediction of the mechanical signals…”
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Periosteum, bone's “smart” bounding membrane, exhibits direction‐dependent permeability by Evans, Sarah F, Parent, Jonathan B, Lasko, Colin E, Zhen, Xiaowen, Knothe, Ulf R, Lemaire, Thibault, Knothe Tate, Melissa L

“…The periosteum serves as bone's bounding membrane, exhibits hallmarks of semipermeable epithelial barrier membranes, and contains mechanically sensitive…”
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Mapping the mechanome of live stem cells using a novel method to measure local strain fields in situ at the fluid-cell interface by Song, Min Jae, Brady-Kalnay, Susann M, McBride, Sara H, Phillips-Mason, Polly, Dean, David, Knothe Tate, Melissa L

“…During mesenchymal condensation, the initial step of skeletogenesis, transduction of minute mechanical forces to the nucleus is associated with up or…”
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Creating High-Resolution Multiscale Maps of Human Tissue Using Multi-beam SEM by Pereira, André F, Hageman, Daniel J, Garbowski, Tomasz, Riedesel, Christof, Knothe, Ulf, Zeidler, Dirk, Knothe Tate, Melissa L

“…Multi-beam scanning electron microscopy (mSEM) enables high-throughput, nano-resolution imaging of macroscopic tissue samples, providing an unprecedented means…”
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Anisotropic mechanical properties of ovine femoral periosteum and the effects of cryopreservation by McBride, Sarah H, Evans, Sarah F, Knothe Tate, Melissa L

“…Abstract The mechanical properties of periosteum are not well characterized. An understanding of these properties is critical to predict the environment of…”
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Translating Periosteum's Regenerative Power: Insights From Quantitative Analysis of Tissue Genesis With a Periosteum Substitute Implant by Moore, Shannon R., Heu, Céline, Yu, Nicole Y.C., Whan, Renee M., Knothe, Ulf R., Milz, Stefan, Knothe Tate, Melissa L.

“…This study used an interdisciplinary, quantitative approach to assess tissue genesis in modular periosteum substitute implants, with the aim to provide…”
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Arthritic Periosteal Tissue From Joint Replacement Surgery: A Novel, Autologous Source of Stem Cells by Chang, Hana, Docheva, Denitsa, Knothe, Ulf R., Knothe Tate, Melissa L.

“…The overarching aim of this study is to assess the feasibility of using periosteal tissue from the femoral neck of arthritic hip joints, usually discarded in…”
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Mechanistic, mathematical model to predict the dynamics of tissue genesis in bone defects via mechanical feedback and mediation of biochemical factors by Moore, Shannon R, Saidel, Gerald M, Knothe, Ulf, Knothe Tate, Melissa L

“…The link between mechanics and biology in the generation and the adaptation of bone has been well studied in context of skeletal development and fracture…”
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Net Change in Periosteal Strain During Stance Shift Loading After Surgery Correlates to Rapid De Novo Bone Generation in Critically Sized Defects by McBride, Sarah H., Dolejs, Scott, Brianza, Stefano, Knothe, Ulf, Knothe Tate, Melissa L.

“…In an ovine femur model, proliferative woven bone fills critically sized defects enveloped by periosteum within 2 weeks of treatment with the one-stage…”
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Modulation of stem cell shape and fate B: mechanical modulation of cell shape and gene expression by McBride, Sara H, Falls, Thomas, Knothe Tate, Melissa L

“…Condensation is a metamorphizing event for the mesenchymal stem cell. The balance of forces in the cell during condensation plays a key role in determining…”
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Effects of mechanical loading patterns, bone graft, and proximity to periosteum on bone defect healing by Knothe, Ulf R, Dolejs, Scott, Matthew Miller, R, Knothe Tate, Melissa L

“…Abstract The goal of this study is to elucidate whether mechanobiological factors, including mechanical loading patterns, presence of bone graft, and proximity…”
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In situ spatiotemporal mapping of flow fields around seeded stem cells at the subcellular length scale by Song, Min Jae, Dean, David, Knothe Tate, Melissa L

“…A major hurdle to understanding and exploiting interactions between the stem cell and its environment is the lack of a tool for precise delivery of mechanical…”
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Surgical membranes as directional delivery devices to generate tissue: testing in an ovine critical sized defect model by Knothe Tate, Melissa L, Chang, Hana, Moore, Shannon R, Knothe, Ulf R

“…Pluripotent cells residing in the periosteum, a bi-layered membrane enveloping all bones, exhibit a remarkable regenerative capacity to fill in critical sized…”
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