Search Results - "Tate, G."

Impact of GPCR Structures on Drug Discovery by Congreve, Miles, de Graaf, Chris, Swain, Nigel A., Tate, Christopher G.

“…Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the…”
Get full text

Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development by García-Nafría, Javier, Tate, Christopher G

“…Electron cryo-microscopy (cryo-EM) has revolutionized structure determination of membrane proteins and holds great potential for structure-based drug…”
Get full text

Who makes acquisitions? CEO overconfidence and the market's reaction by Malmendier, Ulrike, Tate, Geoffrey

“…Does CEO overconfidence help to explain merger decisions? Overconfident CEOs over-estimate their ability to generate returns. As a result, they overpay for…”
Get full text

Structure of the adenosine A2A receptor bound to an engineered G protein by Carpenter, Byron, Nehmé, Rony, Warne, Tony, Leslie, Andrew G. W., Tate, Christopher G.

“…An engineered G protein is used to bind to and stabilize the active conformation of the adenosine A 2A receptor, enabling the acquisition of an X-ray crystal…”
Get full text

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells by Wan, Qingwen, Okashah, Najeah, Inoue, Asuka, Nehmé, Rony, Carpenter, Byron, Tate, Christopher G., Lambert, Nevin A.

“…G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from…”
Get full text

Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go by García-Nafría, Javier, Nehmé, Rony, Edwards, Patricia C., Tate, Christopher G.

“…G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to…”
Get full text

Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces by Carpenter, Byron, Tate, Christopher G

“…[Display omitted] •Active state structures of a μOR–nanobody complex determined to 2.3Å resolution.•The first GPCR–arrestin structure defines the…”
Get full text

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol by Warne, Tony, Edwards, Patricia C., Leslie, Andrew G.W., Tate, Christopher G.

“…The β1-adrenoceptor (β1AR) is the site of action of beta blockers used in the treatment of cardiac-related illnesses. Two beta blockers, carvedilol and…”
Get full text

How Can Mutations Thermostabilize G-Protein-Coupled Receptors? by Vaidehi, Nagarajan, Grisshammer, Reinhard, Tate, Christopher G

“…Structures of over 30 different G-protein-coupled receptors (GPCRs) have advanced our understanding of cell signaling and have provided a foundation for…”
Get full text

Mini-G proteins: Novel tools for studying GPCRs in their active conformation by Nehmé, Rony, Carpenter, Byron, Singhal, Ankita, Strege, Annette, Edwards, Patricia C, White, Courtney F, Du, Haijuan, Grisshammer, Reinhard, Tate, Christopher G

“…Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling…”
Get full text

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling by Yen, Hsin-Yung, Hoi, Kin Kuan, Liko, Idlir, Hedger, George, Horrell, Michael R., Song, Wanling, Wu, Di, Heine, Philipp, Warne, Tony, Lee, Yang, Carpenter, Byron, Plückthun, Andreas, Tate, Christopher G., Sansom, Mark S. P., Robinson, Carol V.

“…G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are therefore key drug targets 1 . Although detailed structural…”
Get full text

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation by Lebon, Guillaume, Warne, Tony, Edwards, Patricia C., Bennett, Kirstie, Langmead, Christopher J., Leslie, Andrew G. W., Tate, Christopher G.

“…Adenosine A 2A receptor structure Adenosine receptors are G protein-coupled receptors that are found in the heart and the brain, and adenosine is the…”
Get full text

Structure of the agonist-bound neurotensin receptor by White, Jim F., Noinaj, Nicholas, Shibata, Yoko, Love, James, Kloss, Brian, Xu, Feng, Gvozdenovic-Jeremic, Jelena, Shah, Priyanka, Shiloach, Joseph, Tate, Christopher G., Grisshammer, Reinhard

“…Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1,…”
Get full text

Molecular basis for high-affinity agonist binding in GPCRs by Warne, Tony, Edwards, Patricia C, Doré, Andrew S, Leslie, Andrew G W, Tate, Christopher G

“…G protein-coupled receptors (GPCRs) in the G protein-coupled active state have higher affinity for agonists as compared with when they are in the inactive…”
Get full text

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region by Venkatakrishnan, A. J., Deupi, Xavier, Lebon, Guillaume, Heydenreich, Franziska M., Flock, Tilman, Miljus, Tamara, Balaji, Santhanam, Bouvier, Michel, Veprintsev, Dmitry B., Tate, Christopher G., Schertler, Gebhard F. X., Babu, M. Madan

“…A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors. Structural…”
Get full text

Structure of the class D GPCR Ste2 dimer coupled to two G proteins by Velazhahan, Vaithish, Ma, Ning, Pándy-Szekeres, Gáspár, Kooistra, Albert J., Lee, Yang, Gloriam, David E., Vaidehi, Nagarajan, Tate, Christopher G.

“…G-protein-coupled receptors (GPCRs) are divided phylogenetically into six classes 1 , 2 , denoted A to F. More than 370 structures of vertebrate GPCRs…”
Get full text

Overexpression of membrane proteins in mammalian cells for structural studies by Andréll, Juni, Tate, Christopher G

“…The number of structures of integral membrane proteins from higher eukaryotes is steadily increasing due to a number of innovative protein engineering and…”
Get more information

Traumatic Spinal Cord Injury and Risk of Early and Late Onset Alzheimer’s Disease and Related Dementia: Large Longitudinal Study by Mahmoudi, Elham, Lin, Paul, Peterson, Mark D., Meade, Michelle A., Tate, Denise G., Kamdar, Neil

“…Traumatic spinal cord injury (TSCI) is a life altering event most often causing permanent physical disability. Little is known about the risk of developing…”
Get full text

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor by Warne, Tony, Moukhametzianov, Rouslan, Baker, Jillian G., Nehmé, Rony, Edwards, Patricia C., Leslie, Andrew G. W., Schertler, Gebhard F. X., Tate, Christopher G.

“…β-adrenergic receptor structures Two papers by Brian Kobilka and colleagues describe the X-ray crystal structure of the human β 2 adrenergic receptor (β 2 AR)…”
Get full text

Assessing controls on ice dynamics at Crane Glacier, Antarctic Peninsula, using a numerical ice flow model by Aberle, Rainey, Enderlin, Ellyn M., Marshall, Hans-Peter, Kopera, Michal, Meehan, Tate G.

“…The Antarctic Peninsula's widespread glacier retreat and ice shelf collapse have been attributed to atmospheric and oceanic warming. Following the initial…”
Get full text