Search Results - "Tate, Edward W."

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets by Lanyon-Hogg, Thomas, Faronato, Monica, Serwa, Remigiusz A., Tate, Edward W.

“…Post-translational attachment of lipids to proteins is found in all organisms, and is important for many biological processes. Acylation with myristic and…”
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Global profiling of co- and post-translationally N-myristoylated proteomes in human cells by Thinon, Emmanuelle, Serwa, Remigiusz A., Broncel, Malgorzata, Brannigan, James A., Brassat, Ute, Wright, Megan H., Heal, William P., Wilkinson, Anthony J., Mann, David J., Tate, Edward W.

“…Protein N -myristoylation is a ubiquitous co- and post-translational modification that has been implicated in the development and progression of a range of…”
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High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation by Dian, Cyril, Pérez-Dorado, Inmaculada, Rivière, Frédéric, Asensio, Thomas, Legrand, Pierre, Ritzefeld, Markus, Shen, Mengjie, Cota, Ernesto, Meinnel, Thierry, Tate, Edward W., Giglione, Carmela

“…The promising drug target N -myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly)…”
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Global profiling of protein lipidation using chemical proteomic technologies by Tate, Edward W, Kalesh, Karunakaran A, Lanyon-Hogg, Thomas, Storck, Elisabeth M, Thinon, Emmanuelle

“…•Protein lipidation is an essential modification (PTM) in all forms of life.•Key modifications include acylation, prenylation, cholesterylation and GPI…”
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Structural basis for membrane attack complex inhibition by CD59 by Couves, Emma C., Gardner, Scott, Voisin, Tomas B., Bickel, Jasmine K., Stansfeld, Phillip J., Tate, Edward W., Bubeck, Doryen

“…CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds…”
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Activity-based probes: discovering new biology and new drug targets by Heal, William P, Dang, T H Tam, Tate, Edward W

“…The development and application of chemical technologies enabling direct analysis of enzyme activity in living systems has undergone explosive growth in recent…”
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Discovery of lipid-mediated protein-protein interactions in living cells using metabolic labeling with photoactivatable clickable probes by Fedoryshchak, Roman O, Gorelik, Andrii, Shen, Mengjie, Shchepinova, Maria M, Pérez-Dorado, Inmaculada, Tate, Edward W

“…Protein-protein interactions (PPIs) are essential and pervasive regulatory elements in biology. Despite the development of a range of techniques to probe PPIs…”
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High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery by Craven, Gregory B., Affron, Dominic P., Allen, Charlotte E., Matthies, Stefan, Greener, Joe G., Morgan, Rhodri M. L., Tate, Edward W., Armstrong, Alan, Mann, David J.

“…Cysteine‐reactive small molecules are used as chemical probes of biological systems and as medicines. Identifying high‐quality covalent ligands requires…”
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Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development by Broncel, Malgorzata, Serwa, Remigiusz A., Ciepla, Paulina, Krause, Eberhard, Dallman, Margaret J., Magee, Anthony I., Tate, Edward W.

“…Novel multifunctional reagents were applied in combination with a lipid probe for affinity enrichment of myristoylated proteins and direct detection of…”
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Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach by Wright, Megan H., Clough, Barbara, Rackham, Mark D., Rangachari, Kaveri, Brannigan, James A., Grainger, Munira, Moss, David K., Bottrill, Andrew R., Heal, William P., Broncel, Malgorzata, Serwa, Remigiusz A., Brady, Declan, Mann, David J., Leatherbarrow, Robin J., Tewari, Rita, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W.

“…Malaria is an infectious disease caused by parasites of the genus Plasmodium , which leads to approximately one million deaths per annum worldwide. Chemical…”
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Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases by Kallemeijn, Wouter W, Lueg, Gregor A, Faronato, Monica, Hadavizadeh, Kate, Goya Grocin, Andrea, Song, Ok-Ryul, Howell, Michael, Calado, Dinis P, Tate, Edward W

“…On-target, cell-active chemical probes are of fundamental importance in chemical and cell biology, whereas poorly characterized probes often lead to invalid…”
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d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition by de Chiara, Cesira, Homšak, Miha, Prosser, Gareth A., Douglas, Holly L., Garza-Garcia, Acely, Kelly, Geoff, Purkiss, Andrew G., Tate, Edward W., de Carvalho, Luiz Pedro S.

“…The broad-spectrum antibiotic d -cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis. DCS, a…”
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Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry by Priyamvada, Lalita, Kallemeijn, Wouter W, Faronato, Monica, Wilkins, Kimberly, Goldsmith, Cynthia S, Cotter, Catherine A, Ojeda, Suany, Solari, Roberto, Moss, Bernard, Tate, Edward W, Satheshkumar, Panayampalli Subbian

“…We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral…”
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Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs by Beard, Rhiannon, Stucki, Andy, Schmitt, Muriel, Py, Gabrielle, Grundschober, Christophe, Gee, Antony D., Tate, Edward W.

“…[Display omitted] •Unique SAR discovered for xylene-bridged oxytocin peptide analogs.•Affinity, selectivity and potency influenced by bridging distance.•Meta…”
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Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry by Heal, William P, Wright, Megan H, Thinon, Emmanuelle, Tate, Edward W

“…A protocol for selective and site-specific enzymatic labeling of proteins is described. The method exploits the protein co-/post-translational modification…”
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Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins by Alzahofi, Noura, Welz, Tobias, Robinson, Christopher L., Page, Emma L., Briggs, Deborah A., Stainthorp, Amy K., Reekes, James, Elbe, David A., Straub, Felix, Kallemeijn, Wouter W., Tate, Edward W., Goff, Philip S., Sviderskaya, Elena V., Cantero, Marta, Montoliu, Lluis, Nedelec, Francois, Miles, Amanda K., Bailly, Maryse, Kerkhoff, Eugen, Hume, Alistair N.

“…Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary,…”
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Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT) by Lanyon‐Hogg, Thomas, Ritzefeld, Markus, Zhang, Leran, Andrei, Sebastian A., Pogranyi, Balazs, Mondal, Milon, Sefer, Lea, Johnston, Callum D., Coupland, Claire E., Greenfield, Jake L., Newington, Joshua, Fuchter, Matthew J., Magee, Anthony I., Siebold, Christian, Tate, Edward W.

“…The mammalian membrane‐bound O‐acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing…”
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Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics by Kalesh, Karunakaran A, Clulow, James A, Tate, Edward W

“…Zerumbone is a phytochemical with diverse biological activities ranging from anti-inflammatory to anti-cancer properties; however, to date the cellular targets…”
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Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation by Guttery, David S., Poulin, Benoit, Ramaprasad, Abhinay, Wall, Richard J., Ferguson, David J.P., Brady, Declan, Patzewitz, Eva-Maria, Whipple, Sarah, Straschil, Ursula, Wright, Megan H., Mohamed, Alyaa M.A.H., Radhakrishnan, Anand, Arold, Stefan T., Tate, Edward W., Holder, Anthony A., Wickstead, Bill, Pain, Arnab, Tewari, Rita

“…Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria…”
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Dynamics and Molecular Interactions of GPI-Anchored CD59 by Voisin, Tomas B, Couves, Emma C, Tate, Edward W, Bubeck, Doryen

“…CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the…”
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