Search Results - "Tatar, Marc"

The plate half-full: Status of research on the mechanisms of dietary restriction in Drosophila melanogaster by Tatar, Marc

“…It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as…”
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Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function by Tatar, Marc

“…Mutations of the insulin-like receptor in extend lifespan. New research suggests this receptor operates in two modes. The first extends lifespan while slowing…”
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Reproductive aging in invertebrate genetic models by Tatar, Marc

“…The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of…”
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Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster by Post, Stephanie, Tatar, Marc

“…Insulin/IGF signaling (IIS) in Drosophila melanogaster is propagated by eight Drosophila insulin-like peptides (dilps) and is regulated by nutrition. To…”
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Drosophila insulin‐like peptide‐6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin‐like peptide‐2 from the brain by Bai, Hua, Kang, Ping, Tatar, Marc

“…Summary Reduced insulin/IGF signaling extends lifespan in diverse species, including Drosophila melanogaster where the genome encodes seven insulin‐like…”
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Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila by Bai, Hua, Kang, Ping, Hernandez, Ana Maria, Tatar, Marc

“…Reduced insulin/IGF signaling increases lifespan in many animals. To understand how insulin/IGF mediates lifespan in Drosophila, we performed chromatin…”
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Unraveling the Molecular Mechanism of Immunosenescence in Drosophila by Min, Kyung-Jin, Tatar, Marc

“…A common feature of the aging process is a decline in immune system performance. Extensive research has sought to elucidate how changes in adaptive immunity…”
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The Endocrine Regulation of Aging by Insulin-like Signals by Tatar, Marc, Bartke, Andrzej, Antebi, Adam

“…Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream…”
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Juvenile hormone regulation of Drosophila aging by Yamamoto, Rochele, Bai, Hua, Dolezal, Adam G, Amdam, Gro, Tatar, Marc

“…Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates…”
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Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila by Birnbaum, Allison, Wu, Xiaofen, Tatar, Marc, Liu, Nan, Bai, Hua

“…FOXO transcription factors have long been associated with longevity control and tissue homeostasis. Although the transcriptional regulation of FOXO have been…”
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Drosophila insulin‐like peptide dilp1 increases lifespan and glucagon‐like Akh expression epistatic to dilp2 by Post, Stephanie, Liao, Sifang, Yamamoto, Rochele, Veenstra, Jan A., Nässel, Dick R., Tatar, Marc

“…Insulin/IGF signaling (IIS) regulates essential processes including development, metabolism, and aging. The Drosophila genome encodes eight insulin/IGF‐like…”
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Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP by Bai, Hua, Post, Stephanie, Kang, Ping, Tatar, Marc

“…Mutations of the insulin/IGF signaling (IIS) pathway extend Drosophila lifespan. Based on genetic epistasis analyses, this longevity assurance is attributed to…”
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Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells by Zheng, Wenjing, Rus, Florentina, Hernandez, Ana, Kang, Ping, Goldman, William, Silverman, Neal, Tatar, Marc

“…Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune…”
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Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis by Zheng, Wenjing, Ocorr, Karen, Tatar, Marc

“…Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes…”
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Drosophila germ-line modulation of insulin signaling and lifespan by Flatt, Thomas, Min, Kyung-Jin, D'Alterio, Cecilia, Villa-Cuesta, Eugenia, Cumbers, John, Lehmann, Ruth, Jones, D. Leanne, Tatar, Marc

“…Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by…”
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Drosophila lifespan control by dietary restriction independent of insulin‐like signaling by Min, Kyung‐Jin, Yamamoto, Rochele, Buch, Susanne, Pankratz, Michael, Tatar, Marc

“…Summary Reduced insulin/insulin‐like growth factor (IGF) signaling may be a natural way for the reduction of dietary nutrients to extend lifespan. While…”
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Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity by Garbuzov, Alina, Tatar, Marc

“…The steroid 20-hydroxy-ecdysone (20-HE) and the sesquiterpenoid Juvenile Hormone (JH) coordinate insect life stage transitions. 20-HE exerts these effects by…”
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Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals by Hong, Seung-Hyun, Lee, Kyu-Sun, Kwak, Su-Jin, Kim, Ae-Kyeong, Bai, Hua, Jung, Min-Su, Kwon, O-Yu, Song, Woo-Joo, Tatar, Marc, Yu, Kweon

“…Feeding behavior is one of the most essential activities in animals, which is tightly regulated by neuroendocrine factors. Drosophila melanogaster short…”
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Restriction of amino acids extends lifespan in Drosophila melanogaster by Min, Kyung-Jin, Tatar, Marc

“…Dietary restriction extends adult Drosophila melanogaster life span when the concentration of dietary yeast is diluted in a media with abundant carbohydrates…”
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Insulin regulation of heart function in aging fruit flies by Bodmer, Rolf, Wessells, Robert J, Fitzgerald, Erin, Cypser, James R, Tatar, Marc

“…Insulin-IGF receptor (InR) signaling has a conserved role in regulating lifespan, but little is known about the genetic control of declining organ function…”
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