Search Results - "Tassotto, Mary Lynn"

Assessing the Metabolic Function of the MutT 8-Oxodeoxyguanosine Triphosphatase in Escherichia coli by Nucleotide Pool Analysis by Tassotto, Mary Lynn, Mathews, Christopher K.

“…In Escherichia coli themutT gene is one of several that acts to minimize mutagenesis by reactive oxygen species. The bacterial MutT protein and its mammalian…”
Get full text

Ribonucleotide Reductase, a Possible Agent in Deoxyribonucleotide Pool Asymmetries Induced by Hypoxia by Chimploy, Korakod, Tassotto, Mary Lynn, Mathews, Christopher K.

“…While investigating the basis for marked natural asymmetries in deoxyribonucleoside triphosphate (dNTP) pools in mammalian cells, we observed that culturing…”
Get full text

Structural analogues of diosgenyl saponins: Synthesis and anticancer activity by Kaskiw, Matthew J., Tassotto, Mary Lynn, Mok, Mac, Tokar, Stacey L., Pycko, Roxanne, Th’ng, John, Jiang, Zi-Hua

“…Saponins display various biological activities including anti-tumor activity. Recently intensive research has been focused on developing saponins for tumor…”
Get full text

Abstract B48: Germline mutations in BRCA1 and BRCA2 as predictive biomarkers of therapy response by Tassotto, Mary Lynn, Sutherland, Lindsay, Th'ng, John

“…Abstract The results of in vitro chemosensitivity studies have shown some consistency with response to chemotherapy in patients, indicating that this approach…”
Get full text

Synthesis and cytotoxic activity of diosgenyl saponin analogues by Kaskiw, Matthew J., Tassotto, Mary Lynn, Th’ng, John, Jiang, Zi-Hua

“…Diosgenyl saponins are steroidal glycosides that are often found as major components in many traditional oriental medicines. Recently, a number of naturally…”
Get full text

[Tris(pyrazolyl)methane]ruthenium Complexes Capable of Inhibiting Cancer Cell Growth by Walker, Jesse M., McEwan, Alexis, Pycko, Roxanne, Tassotto, Mary Lynn, Gottardo, Christine, Th'ng, John, Wang, Ruiyao, Spivak, Gregory J.

“…The [tris(pyrazolyl)methane]ruthenium complexes [(κ3‐tpm)RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(κ3‐tpm)RuCl(LL)]PF6 [LL =…”
Get full text

Deoxyguanosine triphosphate, a possible target for reactive oxygen species-induced mutagenesis by Tassotto, Mary Lynn Benka

“…Intracellular dNTP pool sizes are highly asymmetric, with dGTP usually comprising 5 to 10% of the sum of the dNTP pools. The work presented in this…”
Get full text