Search Results - "Tashlitsky, Vadim"

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel by Osterman, Ilya A., Wieland, Maximiliane, Maviza, Tinashe P., Lashkevich, Kseniya A., Lukianov, Dmitrii A., Komarova, Ekaterina S., Zakalyukina, Yuliya V., Buschauer, Robert, Shiriaev, Dmitrii I., Leyn, Semen A., Zlamal, Jaime E., Biryukov, Mikhail V., Skvortsov, Dmitry A., Tashlitsky, Vadim N., Polshakov, Vladimir I., Cheng, Jingdong, Polikanov, Yury S., Bogdanov, Alexey A., Osterman, Andrei L., Dmitriev, Sergey E., Beckmann, Roland, Dontsova, Olga A., Wilson, Daniel N., Sergiev, Petr V.

“…The increase in multi-drug resistant pathogenic bacteria is making our current arsenal of clinically used antibiotics obsolete, highlighting the urgent need…”
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Brain-Derived 11S Regulator (PA28αβ) Promotes Proteasomal Hydrolysis of Elongated Oligoglutamine-Containing Peptides by Kriachkov, Viacheslav A, Gotmanova, Natalia N, Tashlitsky, Vadim N, Bacheva, Anna V

“…Proteins with extended polyglutamine regions are associated with several neurodegenerative disorders, including Huntington’s disease. Intracellular proteolytic…”
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Cationic surfactant coating nanodiamonds: Adsorption and peculiarities by Chernysheva, Maria G., Popov, Andrey G., Tashlitsky, Vadim N., Badun, Gennadii A.

“…[Display omitted] Given the unique properties of nanodiamonds, such as biocompatibility, low cytotoxicity and high adsorption capacity, this material is…”
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Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome by Polikanov, Yury S., Osterman, Ilya A., Szal, Teresa, Tashlitsky, Vadim N., Serebryakova, Marina V., Kusochek, Pavel, Bulkley, David, Malanicheva, Irina A., Efimenko, Tatyana A., Efremenkova, Olga V., Konevega, Andrey L., Shaw, Karen J., Bogdanov, Alexey A., Rodnina, Marina V., Dontsova, Olga A., Mankin, Alexander S., Steitz, Thomas A., Sergiev, Petr V.

“…We demonstrate that the antibiotic amicoumacin A (AMI) is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the…”
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Nicotiana benthamiana Kunitz peptidase inhibitor-like protein involved in chloroplast-to-nucleus regulatory pathway in plant-virus interaction by Ershova, Natalia, Sheshukova, Ekaterina, Kamarova, Kamila, Arifulin, Evgenii, Tashlitsky, Vadim, Serebryakova, Marina, Komarova, Tatiana

“…Plant viruses use a variety of strategies to infect their host. During infection, viruses cause symptoms of varying severity, which are often associated with…”
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Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors by Osterman, Ilya A, Komarova, Ekaterina S, Shiryaev, Dmitry I, Korniltsev, Ilya A, Khven, Irina M, Lukyanov, Dmitry A, Tashlitsky, Vadim N, Serebryakova, Marina V, Efremenkova, Olga V, Ivanenkov, Yan A, Bogdanov, Alexey A, Sergiev, Petr V, Dontsova, Olga A

“…In order to accelerate drug discovery, a simple, reliable, and cost-effective system for high-throughput identification of a potential antibiotic mechanism of…”
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Membrane Permeability of Modified Butyltriphenylphosphonium Cations by Rokitskaya, Tatyana I, Aleksandrova, Ekaterina V, Korshunova, Galina A, Khailova, Ljudmila S, Tashlitsky, Vadim N, Luzhkov, Victor B, Antonenko, Yuri N

“…The alkyltriphenylphosphonium (TPP) group is the most widely used vector targeted to mitochondria. Previously, the length of the alkyl linker was varied as…”
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The transient character of mitochondrial uncoupling by the popular fungicide fluazinam is specific for liver by Khailova, Ljudmila S., Krasnov, Vladimir S., Kirsanov, Roman S., Popova, Lyudmila B., Tashlitsky, Vadim N., Kotova, Elena A., Antonenko, Yuri N.

“…The popular fungicide fluazinam is known to exhibit an unusual cyclic pattern of the protonophoric uncoupling activity in isolated rat liver mitochondria…”
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An easy tool to monitor the elemental steps of in vitro translation via gel electrophoresis of fluorescently labeled small peptides by Marina, Valeriya I, Bidzhieva, Medina, Tereshchenkov, Andrey G, Orekhov, Dmitry, Sagitova, Vladislava E, Sumbatyan, Nataliya V, Tashlitsky, Vadim N, Ferberg, Artem S, Maviza, Tinashe P, Kasatsky, Pavel, Tolicheva, Olga, Paleskava, Alena, Polshakov, Vladimir I, Osterman, Ilya A, Dontsova, Olga A, Konevega, Andrey L, Sergiev, Petr V

“…Several methods are available to visualize and assess the kinetics and efficiency of elemental steps of protein biosynthesis. However, each of these methods…”
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The Functional Role of Loops and Flanking Sequences of G-Quadruplex Aptamer to the Hemagglutinin of Influenza a Virus by Bizyaeva, Anastasia A, Bunin, Dmitry A, Moiseenko, Valeria L, Gambaryan, Alexandra S, Balk, Sonja, Tashlitsky, Vadim N, Arutyunyan, Alexander M, Kopylov, Alexey M, Zavyalova, Elena G

“…Nucleic acid aptamers are generally accepted as promising elements for the specific and high-affinity binding of various biomolecules. It has been shown for a…”
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Is the Mitochondrial Membrane Potential (∆Ψ) Correctly Assessed? Intracellular and Intramitochondrial Modifications of the ∆Ψ Probe, Rhodamine 123 by Zorova, Ljubava D, Demchenko, Evgeniya A, Korshunova, Galina A, Tashlitsky, Vadim N, Zorov, Savva D, Andrianova, Nadezda V, Popkov, Vasily A, Babenko, Valentina A, Pevzner, Irina B, Silachev, Denis N, Plotnikov, Egor Y, Zorov, Dmitry B

“…The mitochondrial membrane potential (∆Ψ) is the driving force providing the electrical component of the total transmembrane potential of hydrogen ions…”
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Lipophilic ion aromaticity is not important for permeability across lipid membranes by Rokitskaya, Tatyana I., Kotova, Elena A., Luzhkov, Victor B., Kirsanov, Roman S., Aleksandrova, Ekaterina V., Korshunova, Galina A., Tashlitsky, Vadim N., Antonenko, Yuri N.

“…To clarify the contribution of charge delocalization in a lipophilic ion to the efficacy of its permeation through a lipid membrane, we compared the behavior…”
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Covalent Bi-Modular Parallel and Antiparallel G-Quadruplex DNA Nanocostructs Reduce Viability of Patient Glioma Primary Cell Cultures by Legatova, Valeria, Samoylenkova, Nadezhda, Arutyunyan, Alexander, Tashlitsky, Vadim, Zavyalova, Elena, Usachev, Dmitry, Pavlova, Galina, Kopylov, Alexey

“…G-quadruplex oligonucleotides (GQs) exhibit specific anti-proliferative activity in human cancer cell lines, and they can selectively inhibit the…”
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Mitochondrial peptide Mtln contributes to oxidative metabolism in mice by Averina, Olga A., Permyakov, Oleg A., Emelianova, Mariia A., Grigoryeva, Olga O., Gulyaev, Mikhail V., Pavlova, Olga S., Mariasina, Sofia S., Frolova, Olga Yu, Kurkina, Marina V., Baydakova, Galina V., Zakharova, Ekaterina Yu, Marey, Maria V., Tsarev, Dmitry A., Tashlitsky, Vadim N., Popov, Vladimir S., Lovat, Maxim L., Polshakov, Vladimir I., Vyssokikh, Mikhail Yu, Sergiev, Petr V.

“…Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory…”
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Biological evaluation and spectral characterization of a novel tetracenomycin X congener by Alferova, Vera A., Maviza, Tinashe P., Biryukov, Mikhail V., Zakalyukina, Yuliya V., Lukianov, Dmitrii A., Skvortsov, Dmitry A., Vasilyeva, Lilia A., Tashlitsky, Vadim N., Polshakov, Vladimir I., Sergiev, Petr V., Korshun, Vladimir A., Osterman, Ilya A.

“…The aromatic polyketide tetracenomycin X (TcmX) was recently found to be a potent inhibitor of protein synthesis; its binding site is located in a unique locus…”
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Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells by Kostyuk, Svetlana V, Kvasha, Margarita A, Khrabrova, Daria A, Kirsanova, Olga V, Ershova, Elizaveta S, Malinovskaya, Elena M, Veiko, Natalia N, Ivanov, Alexander A, Koval, Vasiliy S, Zhuze, Alexei L, Tashlitsky, Vadim H, Umriukhin, Pavel E, Kutsev, Sergey I, Gromova, Elizaveta S

“…Hypermethylation is observed in the promoter regions of suppressor genes in the tumor cancer cells. Reactivation of these genes by demethylation of their…”
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Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin by Zavyalova, Elena G, Legatova, Valeriia A, Alieva, Rugiya Sh, Zalevsky, Arthur O, Tashlitsky, Vadim N, Arutyunyan, Alexander M, Kopylov, Alexey M

“…Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to…”
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Nybomycin-producing Streptomyces isolated from carpenter ant Camponotus vagus by Zakalyukina, Yuliya V., Birykov, Mikhail V., Lukianov, Dmitrii A., Shiriaev, Dmitrii I., Komarova, Ekaterina S., Skvortsov, Dmitry A., Kostyukevich, Yury, Tashlitsky, Vadim N., Polshakov, Vladimir I., Nikolaev, Eugene, Sergiev, Petr V., Osterman, Ilya A.

“…A novel strain of Actinomycetes was isolated from the body of an ant (Camponotus vagus Scopoli) and its genetic and morphological properties were…”
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Alkyl esters of umbelliferone-4-acetic acid as protonophores in bilayer lipid membranes and ALDH2-dependent soft uncouplers in rat liver mitochondria by Krasnov, Vladimir S., Kirsanov, Roman S., Khailova, Ljudmila S., Firsov, Alexander M., Nazarov, Pavel A., Tashlitsky, Vadim N., Korshunova, Galina A., Kotova, Elena A., Antonenko, Yuri N.

“…[Display omitted] •Alkyl esters of umbelliferone-4-acetic acid (UB-4 esters) uncoupled mitochondria.•Uncoupling of isolated rat liver mitochondria by UB-4…”
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Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome by Khairullina, Zimfira Z., Makarov, Gennady I., Tereshchenkov, Andrey G., Buev, Vitaly S., Lukianov, Dmitrii A., Polshakov, Vladimir I., Tashlitsky, Vadim N., Osterman, Ilya A., Sumbatyan, Natalia V.

“…Design and synthesis of conjugates consisting of the macrolide antibiotic desmycosin and fragments of the antibacterial peptide oncocin were performed in…”
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