Search Results - "Tasaki, Mamoru"

IL-7 coupled with IL-12 increases intratumoral T cell clonality, leading to complete regression of non-immunogenic tumors by Tasaki, Mamoru, Yamashita, Midori, Arai, Yukinori, Nakamura, Takafumi, Nakao, Shinsuke

“…Immune checkpoint inhibitors against PD-1, PD-L1 and CTLA-4 have altered the treatment paradigm for various types of cancers in the past decade. However, they…”
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Oncolytic vaccinia virus induces a novel phenotype of CD8+ effector T cells characterized by high ICOS expression by Yamashita, Midori, Tasaki, Mamoru, Murakami, Ryuji, Arai, Yukinori, Nakamura, Takafumi, Nakao, Shinsuke

“…Characterization of the intratumoral immune status is important for developing immunotherapies and evaluating their antitumor effectiveness. CD8+ T cells are…”
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Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade by Nakao, Shinsuke, Arai, Yukinori, Tasaki, Mamoru, Yamashita, Midori, Murakami, Ryuji, Kawase, Tatsuya, Amino, Nobuaki, Nakatake, Motomu, Kurosaki, Hajime, Mori, Masamichi, Takeuchi, Masahiro, Nakamura, Takafumi

“…The immune status of the tumor microenvironment is a key indicator in determining the antitumor effectiveness of immunotherapies. Data support the role of…”
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Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions by Kunikawa, Shigeki, Tanaka, Akira, Takasuna, Yuji, Tasaki, Mamoru, Chida, Noboru

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as…”
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A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model by Kunikawa, Shigeki, Tanaka, Akira, Takasuna, Yuji, Tasaki, Mamoru, Chida, Noboru

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and is an attractive target for the treatment of T cell-mediated…”
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Leber's hereditary optic neuropathy with 14484 mutation in Central Java, Indonesia by Nishioka, Tomoki, Tasaki, Mamoru, Soemantri, Augustinus, Dyat, Marbaniati, Susanto, J C, Tamam, Moedrik, Sudarmanto, Bambang, Ishida, Takafumi

“…Leber's hereditary optic neuropathy (LHON) is a maternally inherited late-onset form of blindness characterized by acute or subacute bilateral retinal…”
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Abstract 4561: Oncolytic vaccinia virus encoding IL-7 and IL-12 systemically sensitizes tumors to anti-PD-1 antibody in a syngeneic mouse model by Nakao, Shinsuke, Yamashita, Midori, Tasaki, Mamoru, Kawase, Tatsuya, Nakatake, Motomu, Kurosaki, Hajime, Mori, Masamichi, Takeuchi, Masahiro, Nakamura, Takafumi

“…Abstract Immune checkpoint blockade targeting PD-1, PD-L1 and CTLA-4 have demonstrated remarkable clinical responses in patients with advanced cancers;…”
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Abstract B019: Effect of oncolytic vaccinia virus-induced IL-7 and IL-12 expression on tumor immune microenvironment in poorly immunogenic murine cancer by Nakao, Shinsuke, Arai, Yukinori, Tasaki, Mamoru, Yamashita, Midori, Amino, Nobuaki, Murakami, Ryuji, Kawase, Tatsuya, Nakatake, Motomu, Kurosaki, Hajime, Mori, Masamichi, Takeuchi, Masahiro, Nakamura, Takafumi

“…Abstract While immune checkpoint inhibitors have markedly improved therapeutic outcomes for cancer patients, only a subset of patients exhibit a long-term…”
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Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug–drug interactions and P-gp liability by Kunikawa, Shigeki, Tanaka, Akira, Mukoyoshi, Koichiro, Nagashima, Shinya, Tominaga, Hiroaki, Chida, Noboru, Tasaki, Mamoru, Shirai, Fumiyuki

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as…”
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Abstract 5735: Novel KRAS G12D degrader ASP3082 demonstrates in vivo, dose-dependent KRAS degradation, KRAS pathway inhibition, and antitumor efficacy in multiple KRAS G12D-mutated cancer models by Nagashima, Takeyuki, Yoshinari, Tomohiro, Nishizono, Yoshihiro, Tasaki, Mamoru, Inamura, Kohei, Ishioka, Hiroki, Suzuki, Atsushi, Osaki, Fumio, Yamanaka, Yosuke, Hayakawa, Masahiko

“…Abstract KRAS is one of the most frequently mutated oncogenes in various cancers. Among KRAS mutations, KRAS G12D is the most frequent driver mutation and is…”
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Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity by Fukahori, Hidehiko, Chida, Noboru, Maeda, Masashi, Tasaki, Mamoru, Kawashima, Tomoko, Matsuoka, Hideaki, Suzuki, Keiko, Ishikawa, Takeshi, Tanaka, Akira, Higashi, Yasuyuki

“…T cell-mediated immunity is central to the pathogenesis of autoimmune diseases, and is a target in the development of alternative therapeutic strategies with…”
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Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation by Fukahori, Hidehiko, Chida, Noboru, Maeda, Masashi, Tasaki, Mamoru, Kawashima, Tomoko, Noto, Takahisa, Tsujimoto, Susumu, Nakamura, Koji, Oshima, Shinsuke, Hirose, Jun, Higashi, Yasuyuki, Morokata, Tatsuaki

“…Selective inhibition of protein kinase Cθ (PKCθ) may be useful in inducing T cell-specific immunosuppression with a reduced rate of side effects. To our…”
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Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of “chemoattractant receptor homologous molecule expressed on Th2 cells” (CRTH2) by Tasaki, Mamoru, Kobayashi, Miki, Tenda, Yoshiyuki, Tsujimoto, Susumu, Nakazato, Shoko, Numazaki, Mako, Hirano, Yasuno, Matsuda, Hiroshi, Terasaka, Tadashi, Miyao, Yasuhiro, Shimizu, Yasuaki, Hirayama, Yoshitaka

“…Chemoattractant receptor homologous molecule expressed on T helper type 2 cells (CRTH2) is a PGD2 receptor found on eosinophils, basophils, and Th2 type T…”
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