Search Results - "Tarudji, Aria W."
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Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
Published in Nanomedicine (01-10-2017)“…Abstract Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo-therapies. Therefore,…”
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Ultrasmall Mixed Eu–Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI
Published in ACS omega (07-07-2020)“…Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI can have a long-term impact on the quality of life for survivors of all…”
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Antioxidant thioether core-crosslinked nanoparticles prevent the bilateral spread of secondary injury to protect spatial learning and memory in a controlled cortical impact mouse model of traumatic brain injury
Published in Biomaterials (01-05-2021)“…The secondary phase of traumatic brain injury (TBI) is partly caused by the release of excess reactive oxygen species (ROS) from the primary injury. However,…”
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Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury
Published in Journal of controlled release (01-03-2023)“…Following traumatic brain injury (TBI), reactive oxygen species (ROS) are released in excess, causing oxidative stress, carbonyl stress, and cell death, which…”
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Traumatic brain injury heterogeneity affects cell death and autophagy
Published in Experimental brain research (01-07-2024)“…Traumatic brain injury (TBI) mechanism and severity are heterogenous clinically, resulting in a multitude of physical, cognitive, and behavioral deficits…”
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Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood–Brain Barrier
Published in ACS nano (23-11-2021)“…Aging-induced alterations to the blood–brain barrier (BBB) are increasingly being seen as a primary event in chronic progressive neurological disorders that…”
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Theranostic Copolymers Neutralize Reactive Oxygen Species and Lipid Peroxidation Products for the Combined Treatment of Traumatic Brain Injury
Published in Biomacromolecules (11-04-2022)“…Traumatic brain injury (TBI) results in the generation of reactive oxygen species (ROS) and lipid peroxidation product (LPOx), including acrolein and…”
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Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via Ktrans mapping with MRI
Published in Scientific reports (06-11-2019)“…Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve…”
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Antioxidant Theranostic Copolymer‐Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model
Published in Advanced therapeutics (01-12-2023)“…Following a traumatic brain injury (TBI), excess reactive oxygen species (ROS) and lipid peroxidation products (LPOx) are generated and lead to secondary…”
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Understanding the Role of Antioxidant Nanoparticles in Improving the Outcome of Secondary Injury in Traumatic Brain Injury
Published 01-01-2022“…Following traumatic brain injury (TBI), excess reactive oxygen species (ROS) and other free radicals are released, inducing the cascade of secondary injury…”
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Dissertation -
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Antioxidant Theranostic Copolymer‐Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model (Adv. Therap. 12/2023)
Published in Advanced therapeutics (01-12-2023)“…There are currently no approved therapies that reduce the spread of secondary injury following a traumatic brain injury. In article 2300147, Forrest M. Kievit…”
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Journal Article -
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Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via K trans mapping with MRI
Published in Scientific reports (06-11-2019)“…Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve…”
Get full text
Journal Article