Search Results - "Tarrant, Richard D."

Host cell protein adsorption characteristics during protein a chromatography by Tarrant, Richard D. R., Velez-Suberbie, M. Lourdes, Tait, Andrew S., Smales, C. Mark, Bracewell, Daniel G.

“…Protein A chromatography is a critical and ‘gold‐standard’ step in the purification of monoclonal antibody (mAb) products. Its ability to remove >98% of…”
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Impact of aeration strategy on CHO cell performance during antibody production by Velez-Suberbie, M. Lourdes, Tarrant, Richard D. R., Tait, Andrew S., Spencer, Daniel I. R., Bracewell, Daniel G.

“…Stirred tank bioreactors using suspension adapted mammalian cells are typically used for the production of complex therapeutic proteins. The hydrodynamic…”
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Production of a high purity, C‐tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions by Mukhopadhyay, Ekta, Brod, Florian, Angell‐Manning, Philip, Green, Nicola, Tarrant, Richard D., Detmers, Frank J., Bolam, Emma J., Baleanu, Ioana N., Hobson, Mark, Whale, Gary, Morris, Susan J., Ashfield, Rebecca, Gilbert, Sarah C., Jin, Jing, Draper, Simon J., Moyle, Sarah P., Berrie, Eleanor L., Hill, Adrian V. S.

“…Virus‐like particles (VLPs) induce strong humoral and cellular responses and have formed the basis of some currently licensed vaccines. Here, we present the…”
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An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants by Hogwood, Catherine E.M., Ahmad, Shahina S., Tarrant, Richard D., Bracewell, Daniel G., Smales, C. Mark

“…During the manufacture of biopharmaceutical products, the final product must lie within strict pre‐set specifications, for example the host cell protein (HCP)…”
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Differential response in downstream processing of CHO cells grown under mild hypothermic conditions by Tait, Andrew S., Tarrant, Richard D. R., Velez-Suberbie, M. Lourdes, Spencer, Daniel I. R., Bracewell, Daniel G.

“…The manufacture of complex therapeutic proteins using mammalian cells is well established, with several strategies developed to improve productivity. The…”
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Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells by Jin, Jing, Tarrant, Richard D., Bolam, Emma J., Angell-Manning, Philip, Soegaard, Max, Pattinson, David J., Dulal, Pawan, Silk, Sarah E., Marshall, Jennifer M., Dabbs, Rebecca A., Nugent, Fay L., Barrett, Jordan R., Hjerrild, Kathryn A., Poulsen, Lars, Jørgensen, Thomas, Brenner, Tanja, Baleanu, Ioana N., Parracho, Helena M., Tahiri-Alaoui, Abdessamad, Whale, Gary, Moyle, Sarah, Payne, Ruth O., Minassian, Angela M., Higgins, Matthew K., Detmers, Frank J., Lawrie, Alison M., Douglas, Alexander D., Smith, Robert, de Jongh, Willem A., Berrie, Eleanor, Ashfield, Rebecca, Draper, Simon J.

“…Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is a leading asexual blood-stage vaccine candidate for malaria. In preparation for…”
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