Search Results - "Tarr, C"

Multistate outbreak of Listeria monocytogenes infections linked to whole apples used in commercially produced, prepackaged caramel apples: United States, 2014–2015 by ANGELO, K. M., CONRAD, A. R., SAUPE, A., DRAGOO, H., WEST, N., SORENSON, A., BARNES, A., DOYLE, M., BEAL, J., JACKSON, K. A., STROIKA, S., TARR, C., KUCEROVA, Z., LANCE, S., GOULD, L. H., WISE, M., JACKSON, B. R.

“…Whole apples have not been previously implicated in outbreaks of foodborne bacterial illness. We investigated a nationwide listeriosis outbreak associated with…”
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Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease by Melancon, Bruce J., Tarr, James C., Panarese, Joseph D., Wood, Michael R., Lindsley, Craig W.

“…•Dysfunction in glutamatergic and cholinergic signaling in schizophrenia is discussed.•The advantages of allosteric modulation are discussed.•Activation of the…”
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Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100 by BYUN, Nellie E, GRANNAN, Michael, MELANCON, Bruce J, TARR, James C, BROGAN, John T, AVISON, Malcolm J, DEUTCH, Ariel Y, WESS, Jürgen, WOOD, Michael R, LINDSLEY, Craig W, GORE, John C, CONN, P. Jeffrey, BUBSER, Michael, JONES, Carrie K, BARRY, Robert L, THOMPSON, Analisa, ROSANELLI, John, GOWRISHANKAR, Raajaram, KELM, Nathaniel D, DAMON, Stephen, BRIDGESL, Thomas M

“…Accumulating evidence suggests that selective M4 muscarinic acetylcholine receptor (mAChR) activators may offer a novel strategy for the treatment of…”
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Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents by Bubser, Michael, Bridges, Thomas M, Dencker, Ditte, Gould, Robert W, Grannan, Michael, Noetzel, Meredith J, Lamsal, Atin, Niswender, Colleen M, Daniels, J. Scott, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Byers, Frank W, Wess, Jürgen, Duggan, Mark E, Dunlop, John, Wood, Michael W, Brandon, Nicholas J, Wood, Michael R, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K

“…Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the treatment of psychotic symptoms…”
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Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs by Wood, Michael R, Noetzel, Meredith J, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B, Weiner, Rebecca L, Cho, Hyekyung P, Bubser, Michael, Jones, Carrie K, Niswender, Colleen M, Wood, Michael W, Engers, Darren W, Brandon, Nicholas J, Duggan, Mark E, Conn, P Jeffrey, Bridges, Thomas M, Lindsley, Craig W

“…This letter describes the chemical optimization of a novel series of M positive allosteric modulators (PAMs) based on a 5-amino-thieno[2,3-c]pyridazine core,…”
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Response of Sunmuscat (Vitis vinifera L.) to Varying Cane Numbers When Managed on a Shaw Swing-Arm Trellis for Dried Grape Production by Clingeleffer, P. R., Tarr, C. A.

“…Background and Aims. Dried grapes from Sunmuscat compose more than 50% of Australia’s production. Sunmuscat is late ripening which can lead to suboptimal…”
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carrier prevalence of severe combined immunodeficiency, lavender foal syndrome and cerebellar abiotrophy in Arabian horses in South Africa by Tarr, C. J, Thompson, P. N, Guthrie, A. J, Harper, C. K

“…REASONS FOR PERFORMING STUDY: The carrier prevalence of severe combined immunodeficiency (SCID), lavender foal syndrome (LFS) and cerebellar abiotrophy (CA) in…”
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Lanthanum Tricyanide-Catalyzed Acyl Silane−Ketone Benzoin Additions by Tarr, James C, Johnson, Jeffrey S

“…Lanthanum tricyanide efficiently catalyzes a benzoin-type coupling between acyl silanes and ketones. Yields range from moderate to excellent over a broad…”
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Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides by Tarr, James C, Wood, Michael R, Noetzel, Meredith J, Bertron, Jeanette L, Weiner, Rebecca L, Rodriguez, Alice L, Lamsal, Atin, Byers, Frank W, Chang, Sichen, Cho, Hyekyung P, Jones, Carrie K, Niswender, Colleen M, Wood, Michael W, Brandon, Nicholas J, Duggan, Mark E, Conn, P Jeffrey, Bridges, Thomas M, Lindsley, Craig W

“…This letter details the continued chemical optimization of a novel series of M positive allosteric modulators (PAMs) based on a 5-amino-thieno[2,3-c]pyridazine…”
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Use of Whole Genome Sequencing and Patient Interviews To Link a Case of Sporadic Listeriosis to Consumption of Prepackaged Lettuce by Jackson, K A, Stroika, S, Katz, L S, Beal, J, Brandt, E, Nadon, C, Reimer, A, Major, B, Conrad, A, Tarr, C, Jackson, B R, Mody, R K

“…We report on a case of listeriosis in a patient who probably consumed a prepackaged romaine lettuce-containing product recalled for Listeria monocytogenes…”
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Evolution on a volcanic conveyor belt: using phylogeographic reconstructions and K-Ar-based ages of the Hawaiian Islands to estimate molecular evolutionary rates by FLEISCHER, ROBERT C., MCINTOSH, CARL E., TARR, CHERYL L.

“…The Hawaiian Islands form as the Pacific Plate moves over a ‘hot spot’ in the earth’s mantle where magma extrudes through the crust to build huge shield…”
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Enantioselective Metallophosphite-Catalyzed C-Acylation of Nitrones by Garrett, Mary R, Tarr, James C, Johnson, Jeffrey S

“…Metallophosphites derived from tartaric acid catalyze the enantioselective addition of acyl silanes to nitrones. The product α-N-silyloxyamino ketones are…”
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Listeria monocytogenes Infection in a Sugar Glider (Petaurus breviceps) - New Mexico, 2011 by Nichols, M., Takacs, N., Ragsdale, J., Levenson, D., Marquez, C., Roache, K., Tarr, C. L.

“…Summary Listeria monocytogenes is a Gram‐positive, facultative anaerobic, rod‐shaped bacterium that can infect and cause disease in many species. In this case…”
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Development of a highly selective, orally bioavailable and CNS penetrant M₁ agonist derived from the MLPCN probe ML071 by Lebois, Evan P, Digby, Gregory J, Sheffler, Douglas J, Melancon, Bruce J, Tarr, James C, Cho, Hyekyung P, Miller, Nicole R, Morrison, Ryan, Bridges, Thomas M, Xiang, Zixiu, Scott Daniels, J, Wood, Michael R, Conn, P. Jeffrey, Lindsley, Craig W

“…Herein we report the discovery and SAR of a novel series of M₁ agonists based on the MLPCN probe, ML071. From this, VU0364572 emerged as a potent, orally…”
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Targeting Selective Activation of M1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M1 Positive Allosteric Modulator ML169 by Tarr, James C, Turlington, Mark L, Reid, Paul R, Utley, Thomas J, Sheffler, Douglas J, Cho, Hyekyung P, Klar, Rebecca, Pancani, Tristano, Klein, Michael T, Bridges, Thomas M, Morrison, Ryan D, Blobaum, Anna L, Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M, Conn, P. Jeffrey, Wood, Michael R, Lindsley, Craig W

“…The M1 muscarinic acetylcholine receptor is thought to play an important role in memory and cognition, making it a potential target for the treatment of…”
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Complete Genome Sequence of Vibrio parahaemolyticus Environmental Strain UCM-V493 by Kalburge, S S, Polson, S W, Boyd Crotty, K, Katz, L, Turnsek, M, Tarr, C L, Martinez-Urtaza, J, Boyd, E F

“…Vibrio parahaemolyticus is the leading bacterial cause of seafood-related gastroenteritis in the world. Here, we report the complete genome sequence and…”
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Primers for amplification and determination of mitochondrial control-region sequences in oscine passerines by Tarr, C L

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Cryptic genetic variation and paraphyly in ravens by Omland, Kevin E., Tarr, Cheryl L., Boarman, William I., Marzluff, John M., Fleischer, Robert C.

“…Corvus cryptoleucus…”
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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods by Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death. Amplification of Mcl-1 is…”
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Highly reactive catalysts for aerobic thioether oxidation the Fe-substituted polyoxometalate/hydrogen dinitrate system by OKUN, Nelya M, TARR, James C, HILLESHIEM, Daniel A, LEI ZHANG, HARDCASTLE, Kenneth I, HILL, Craig L

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