Search Results - "Tarpley, W G"

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives by Genin, Michael J, Biles, Carolyn, Keiser, Barb J, Poppe, Susan M, Swaney, Steven M, Tarpley, W. Gary, Yagi, Yoshihiko, Romero, Donna L

“…Through computationally directed broad screening, a novel 1,5-diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has…”
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Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection by Bukrinsky, Michael I., Sharova, Natalia, McDonald, Thomas L., Pushkarskaya, Tatyana, Tarpley, W. Gary, Stevenson, Mario

“…We have examined components of the preintegration complex of human immunodeficiency virus type 1 (HIV-1) and have analyzed features which govern the…”
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Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor by POPPE, S. M, SLADE, D. E, THAISRIVONGS, S, TARPLEY, W. G, CHONG, K.-T, HINSHAW, R. R, PAGANO, P. J, MARKOWITZ, M, HO, D. D, MO, H, GORMAN, R. R, DUEWEKE, T. J

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A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors by Dueweke, Thomas J., Pushkarskaya, Tatyana, Poppe, Susan M., Swaney, Steven M., Zhao, Jia Q., Irvin S. Y. Chen, Stevenson, Mario, Tarpley, W. Gary

“…Several nonnucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have been described, including Nevirapine,…”
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An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection by Ashorn, Per, McQuade, Thomas J., Thaisrivongs, Suvit, Tomasselli, Alfredo G., Tarpley, W. Gary, Moss, Bernard

“…The activity of the human immunodeficiency virus (HIV) protease is essential for processing of the gag-pol precursor proteins and maturation of infectious…”
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Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy by BALZARINI, J, KARLSSON, A, PEREZ-PEREZ, M.-J, CAMARASA, M.-J, TARPLEY, W. G, DE CLERCQ, E

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A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation by McQuade, T. J., Tomasselli, A. G., Liu, L., Karacostas, V., Moss, B., Sawyer, T. K., Heinrikson, R. L., Tarpley, W. G.

“…A synthetic peptidemimetic substrate of the human immunodeficiency virus 1 (HIV-1) protease with a nonhydrolyzable pseudodipeptidyl insert at the protease…”
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Pyrimidine Thioethers:  A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV by Nugent, Richard A, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Poel, Toni J, Wishka, Donn G, Graber, David R, Yagi, Yoshihiko, Keiser, Barbara J, Olmsted, Robert A, Kopta, Laurie A, Swaney, Steven M, Poppe, Susan M, Morris, Joel, Tarpley, W. Gary, Thomas, Richard C

“…A series of pyrimidine thioethers was synthesized and evaluated for inhibitory properties against wild-type HIV-1 reverse transcriptase (RT) and an RT carrying…”
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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor by WISHKA, D. G, GRABER, D. R, KEISER, B. J, YAGI, Y, JEGANATHAN, A, SCHLACHTER, S. T, MURPHY, M. J, CLEEK, G. J, NUGENT, R. A, POPPE, S. M, SWANEY, S. M, HAN, F, KOPTA, L. A, WATT, W, WHITE, W. L, POEL, T.-J, THOMAS, R. C, VOORMAN, R. L, STEFANSKI, K. J, STEHLE, R. G, TARPLEY, W. G, MORRIS, J, OLMSTED, R. A, FRIIS, J. M, HOSLEY, J. D, ADAMS, W. J, SEEST, E. P, CASTLE, T. M, DOLAK, L. A

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U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication by DUEWEKE, T. J, POPPE, S. M, MAYERS, D. L, LANE, J, ARISTOFF, P. A, THOMAS, R. C, TARPLEY, W. G, ROMERO, D. L, SWANEY, S. M, SO, A. G, DOWNEY, K. M, ALTHAUS, I. W, REUSSER, F, BUSSO, M, RESNICK, L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase by Althaus, Irene W., Chou, Kuo-Chen, Lemay, Richelle J., Franks, Kellie M., Deibel, Martin R., Kezdy, Ferenc J., Resnick, Lionel, Busso, Mariano E., So, Antero G., Downey, Kathleen M., Romero, Donna L., Thomas, Richard C., Aristoff, Paul A., Tarpley, W.Gary, Reusser, Fritz

“…U-31,355, or 4-amino-2-(benzylthio)-6-chloropyrimidine is an inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and possesses…”
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The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase by Dueweke, T J, Kézdy, F J, Waszak, G A, Deibel, M R, Tarpley, W G

“…The bisheteroarylpiperazines (BHAPs) are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and specifically block…”
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Targeting Delavirdine/Atevirdine Resistant HIV-1:  Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors by Romero, Donna L, Olmsted, Robert A, Poel, Toni Jo, Morge, Raymond A, Biles, Carolyn, Keiser, Barbara J, Kopta, Laurice A, Friis, Jan M, Hosley, John D, Stefanski, Kevin J, Wishka, Donn G, Evans, David B, Morris, Joel, Stehle, Randy G, Sharma, Satish K, Yagi, Yoshihiko, Voorman, Richard L, Adams, Wade J, Tarpley, W. Gary, Thomas, Richard C

“…A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor)…”
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Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors by Vasudevachari, M B, Battista, C, Lane, H C, Psallidopoulos, M C, Zhao, B, Cook, J, Palmer, J R, Romero, D L, Tarpley, W G, Salzman, N P

“…Certain bisheteroarylpiperazines (BHAPs) directly inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and block the spread of infection to…”
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Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene by Benjamin, Christopher W., Tarpley, W. Gary, Gorman, Robert R.

“…Data indicating that the 21-kDa protein (p21) Harvey-ras gene product shares sequence homology with guanine nucleotide-binding proteins (G proteins) has…”
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Reduced Hormone-Stimulated Adenylate Cyclase Activity in NIH-3T3 Cells Expressing the EJ Human Bladder ras Oncogene by Tarpley, W. Gary, Hopkins, Nancy K., Gorman, Robert R.

“…Recent studies have shown that the 21-kilodalton protein (p21) Ha-ras gene product shares sequence homology with and may exhibit biochemical properties similar…”
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Inhibition of the Protease of Human Immunodeficiency Virus Blocks Replication and Infectivity of the Virus in Chronically Infected Macrophages by Perno, Carlo-Federico, Bergamini, Alberto, Pesce, Caterina D., Milanese, Giuseppe, Capozzi, Marcella, Aquaro, Stefano, Thaisrivongs, Suvit, Tarpley, W. Gary, Zon, Gerald, D'Agostini, Cartesio, Rocchi, Giovanni, Garaci, Enrico, Calió, Raffaele

“…Because of the importance of monocytes/macrophages (M/M) as an in vivo reservoir of human immunodeficiency virus (HIV), a study was done to investigate whether…”
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The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming by TARPLEY, W. G, TEMIN, H. M

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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity by Thaisrivongs, Suvit, Tomasselli, Alfredo G, Moon, Joseph B, Hui, John, McQuade, Thomas J, Turner, Steve R, Strohbach, Joseph W, Howe, W. Jeffrey, Tarpley, W. Gary, Heinrikson, Robert L

“…The peptidomimetic template and the dihydroxyethylene isostere insert that were applied successfully to the design of renin inhibitors have been extended to…”
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Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase by Tan, Cheng Keat, Zhang, Jian, Li, Zhao Yan, Tarpley, W. Gary, Downey, Kathleen M, So, Antero G

“…The DNA polymerase and RNase H activities of HIV reverse transcriptase are both essential for HIV replication. Although the two activities are both catalyzed…”
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