Search Results - "Tarkowski, Bartosz"

Pathological mTOR mutations impact cortical development by Tarkowski, Bartosz, Kuchcinska, Kinga, Blazejczyk, Magdalena, Jaworski, Jacek

“…Abstract Several mosaic mutations of the mammalian/mechanistic target of rapamycin (mTOR) have recently been found in patients with cortical malformations,…”
Get full text

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C by Bilska, Aleksandra, Kusio-Kobiałka, Monika, Krawczyk, Paweł S., Gewartowska, Olga, Tarkowski, Bartosz, Kobyłecki, Kamil, Nowis, Dominika, Golab, Jakub, Gruchota, Jakub, Borsuk, Ewa, Dziembowski, Andrzej, Mroczek, Seweryn

“…TENT5C is a non-canonical cytoplasmic poly(A) polymerase highly expressed by activated B cells to suppress their proliferation. Here we measure the global…”
Get full text

TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice by Brouze, Michał, Czarnocka-Cieciura, Agnieszka, Gewartowska, Olga, Kusio-Kobiałka, Monika, Jachacy, Kamil, Szpila, Marcin, Tarkowski, Bartosz, Gruchota, Jakub, Krawczyk, Paweł, Mroczek, Seweryn, Borsuk, Ewa, Dziembowski, Andrzej

“…Cytoplasmic polyadenylation plays a vital role in gametogenesis; however, the participating enzymes and substrates in mammals remain unclear. Using knockout…”
Get full text

Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2 by Koscielny, Alicja, Malik, Anna R., Liszewska, Ewa, Zmorzynska, Justyna, Tempes, Aleksandra, Tarkowski, Bartosz, Jaworski, Jacek

“…The formation of dendritic arbors in neurons is a highly regulated process. Among the regulators of dendritogenesis are numerous membrane proteins that are…”
Get full text

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation by Gewartowska, Olga, Aranaz-Novaliches, Goretti, Krawczyk, Paweł S., Mroczek, Seweryn, Kusio-Kobiałka, Monika, Tarkowski, Bartosz, Spoutil, Frantisek, Benada, Oldrich, Kofroňová, Olga, Szwedziak, Piotr, Cysewski, Dominik, Gruchota, Jakub, Szpila, Marcin, Chlebowski, Aleksander, Sedlacek, Radislav, Prochazka, Jan, Dziembowski, Andrzej

“…Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals…”
Get full text

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis by Jeric, Ines, Maurer, Gabriele, Cavallo, Anna Lina, Raguz, Josipa, Desideri, Enrico, Tarkowski, Bartosz, Parrini, Matthias, Fischer, Irmgard, Zatloukal, Kurt, Baccarini, Manuela

“…Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths, but its molecular heterogeneity hampers the design of targeted therapies. Currently, the…”
Get full text

Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment by Macias, Matylda, Blazejczyk, Magdalena, Kazmierska, Paulina, Caban, Bartosz, Skalecka, Agnieszka, Tarkowski, Bartosz, Rodo, Anna, Konopacki, Jan, Jaworski, Jacek

“…Mammalian target of rapamycin (mTOR) is a protein kinase that senses nutrient availability, trophic factors support, cellular energy level, cellular stress,…”
Get full text