New molecule in the etiology of schizophrenia: Urotensin II

New molecule in the etiology of schizophrenia: Urotensin II

Aims Urotensin II (U‐II) is a cyclic peptide that was first isolated from the caudal neurosecretory system of goby fish. U‐II receptors were detected in the vascular endothelium, brain and kidney cortex. Urotensin is by far the most powerful vasoconstrictor identified. U‐II molecules were previously...

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Published in:Psychiatry and clinical neurosciences Vol. 68; no. 2; pp. 133 - 136
Main Authors: Bulbul, Feridun, Alpak, Gokay, Unal, Ahmet, Copoglu, Umit Sertan, Orkmez, Mustafa, Virit, Osman, Tarkcıoglu, Mehmet, Savas, Haluk A.
Format: Journal Article
Language:English
Published: Australia Wiley Subscription Services, Inc 01-02-2014
Subjects:
Adult
Female
Humans
Male
Middle Aged
new molecule
oxidative stress
pathogenesis
Psychiatry
Schizophrenia
Schizophrenia - blood
Schizophrenia - etiology
Severity of Illness Index
urotensin II
Urotensins - blood
new molecule
pathogenesis
schizophrenia
urotensin II
oxidative stress
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Summary:Aims Urotensin II (U‐II) is a cyclic peptide that was first isolated from the caudal neurosecretory system of goby fish. U‐II receptors were detected in the vascular endothelium, brain and kidney cortex. Urotensin is by far the most powerful vasoconstrictor identified. U‐II molecules were previously isolated from the brain of rats and were shown to have an impact on rat behavior. The aim of the present study was to measure the level of U‐II molecule in schizophrenia patients and to investigate whether the U‐II level is associated with the etiology of schizophrenia. Methods Forty schizophrenia patients who were followed at Gaziantep University Faculty of Medicine Department of Psychiatry Psychotic Disorders Unit and 40 healthy volunteers were enrolled in this study. Blood samples were taken from the antecubital vein after 12‐h fasting. U‐II level was measured on ELISA. Results The U‐II level in schizophrenia patients was significantly higher than in the control group. U‐II level was not different with regard to gender in either group. U‐II level was not different between subgroups of schizophrenia. No significant correlation was found between U‐II level, Positive and Negative Syndrome Scale and Clinical Global Impression–Severity scale scores. Conclusion U‐II level was higher in schizophrenia patients, indicating that U‐II level may be related to the etiology of the disease.
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ISSN:1323-1316
1440-1819
DOI:10.1111/pcn.12099