Search Results - "Tariq, Rana"

Therapeutic targeting of microRNAs: current status and future challenges by Li, Zhonghan, Rana, Tariq M.

“…Key Points MicroRNAs (miRNAs) have important roles in many aspects of human diseases, and their targeted inhibition may have substantial therapeutic impact…”
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Illuminating the silence: understanding the structure and function of small RNAs by Rana, Tariq M

“…RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small interfering (si)RNAs or that have…”
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Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3 by Dang, Jason, Tiwari, Shashi Kant, Lichinchi, Gianluigi, Qin, Yue, Patil, Veena S., Eroshkin, Alexey M., Rana, Tariq M.

“…Emerging evidence from the current outbreak of Zika virus (ZIKV) indicates a strong causal link between Zika and microcephaly. To investigate how ZIKV…”
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ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment by Li, Na, Kang, Yuqi, Wang, Lingling, Huff, Sarah, Tang, Rachel, Hui, Hui, Agrawal, Kriti, Gonzalez, Gwendolyn Michelle, Wang, Yinsheng, Patel, Sandip Pravin, Rana, Tariq M.

“…Although immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, many patients do not respond or develop resistance to ICB…”
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Dynamics of Human and Viral RNA Methylation during Zika Virus Infection by Lichinchi, Gianluigi, Zhao, Boxuan Simen, Wu, Yinga, Lu, Zhike, Qin, Yue, He, Chuan, Rana, Tariq M.

“…Infection with the flavivirus Zika (ZIKV) causes neurological, immunological, and developmental defects through incompletely understood mechanisms. We report…”
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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54 by Chu, Chia-ying, Rana, Tariq M

“…RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference…”
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Cholesterol 25‐Hydroxylase inhibits SARS‐CoV‐2 and other coronaviruses by depleting membrane cholesterol by Wang, Shaobo, Li, Wanyu, Hui, Hui, Tiwari, Shashi Kant, Zhang, Qiong, Croker, Ben A, Rawlings, Stephen, Smith, Davey, Carlin, Aaron F, Rana, Tariq M

“…Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2 and has spread across the globe. SARS‐CoV‐2 is a highly infectious virus with no vaccine or…”
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Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids by Dang, Jason, Tiwari, Shashi Kant, Agrawal, Kriti, Hui, Hui, Qin, Yue, Rana, Tariq M.

“…Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also causes cognitive impairment, neurotoxicity and neurodevelopmental deficits…”
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An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment by Lin, Nianwei, Chang, Kung-Yen, Li, Zhonghan, Gates, Keith, Rana, Zacharia A., Dang, Jason, Zhang, Danhua, Han, Tianxu, Yang, Chao-Shun, Cunningham, Thomas J., Head, Steven R., Duester, Gregg, Dong, P. Duc Si, Rana, Tariq M.

“…Here, we generated a genome-scale shRNA library targeting long intergenic noncoding RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function…”
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long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL by Li, Zhonghan, Chao, Ti-Chun, Chang, Kung-Yen, Lin, Nianwei, Patil, Veena S., Shimizu, Chisato, Head, Steven R., Burns, Jane C., Rana, Tariq M.

“…Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a…”
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Regulation of antiviral innate immunity by chemical modification of viral RNA by Li, Na, Rana, Tariq M.

“…More than 100 chemical modifications of RNA, termed the epitranscriptome, have been described, most of which occur in prokaryotic and eukaryotic ribosomal,…”
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METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection by Li, Na, Hui, Hui, Bray, Bill, Gonzalez, Gwendolyn Michelle, Zeller, Mark, Anderson, Kristian G., Knight, Rob, Smith, Davey, Wang, Yinsheng, Carlin, Aaron F., Rana, Tariq M.

“…It is urgent and important to understand the relationship of the widespread severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune…”
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Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids by Tiwari, Shashi Kant, Wang, Shaobo, Smith, Davey, Carlin, Aaron F., Rana, Tariq M.

“…COVID-19 is a transmissible respiratory disease caused by a novel coronavirus, SARS-CoV-2, and has become a global health emergency. There is an urgent need…”
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Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers by Yau, Edwin H, Kummetha, Indrasena Reddy, Lichinchi, Gianluigi, Tang, Rachel, Zhang, Yunlin, Rana, Tariq M

“…Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power…”
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A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation by Li, Zhonghan, Rana, Tariq M.

“…Somatic cells can be reprogrammed to form embryonic stem cell-like induced pluripotent stem cells (iPSCs), but the process suffers from low efficiency and the…”
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Gene regulation by non-coding RNAs by Patil, Veena S, Zhou, Rui, Rana, Tariq M

“…The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30…”
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Small RNA-mediated regulation of iPS cell generation by Li, Zhonghan, Yang, Chao-Shun, Nakashima, Katsuhiko, Rana, Tariq M

“…Somatic cells can be reprogrammed to an ES‐like state to create induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors,…”
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Discovery and Mechanism of SARS-CoV‑2 Main Protease Inhibitors by Huff, Sarah, Kummetha, Indrasena Reddy, Tiwari, Shashi Kant, Huante, Matthew B, Clark, Alex E, Wang, Shaobo, Bray, William, Smith, Davey, Carlin, Aaron F, Endsley, Mark, Rana, Tariq M

“…The emergence of a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents an urgent public health crisis. Without available…”
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Rational Design and Optimization of m6A‑RNA Demethylase FTO Inhibitors as Anticancer Agents by Huff, Sarah, Kummetha, Indrasena Reddy, Zhang, Lingzhi, Wang, Lingling, Bray, William, Yin, Jiekai, Kelley, Vanessa, Wang, Yinsheng, Rana, Tariq M.

“…Aberrant regulation of N 6-methyladenosine (m6A) RNA modification has been implicated in the progression of multiple diseases, including cancer. Previously, we…”
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Genome-wide Integrative Analysis of Zika-Virus-Infected Neuronal Stem Cells Reveals Roles for MicroRNAs in Cell Cycle and Stemness by Dang, Jason W., Tiwari, Shashi Kant, Qin, Yue, Rana, Tariq M.

“…Zika virus (ZIKV) infection is implicated in severe fetal developmental disorders, including microcephaly. MicroRNAs (miRNAs) post-transcriptionally regulate…”
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