Search Results - "Targownik, Laura E."

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review by Targownik, Laura E., Fisher, Deborah A., Saini, Sameer D.

“…Proton pump inhibitors (PPIs) are among the most commonly used medications in the world. Developed for the treatment and prevention of acid-mediated upper…”
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The Epidemiology of Colectomy in Ulcerative Colitis: Results From a Population-Based Cohort by TARGOWNIK, Laura E, SINGH, Harminder, NUGENT, Zoann, BERNSTEIN, Charles N

“…Previous studies have reported colectomy rates of over 50% in ulcerative colitis (UC), although changes in management may have influenced the rates of…”
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Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data by Coward, Stephanie, Clement, Fiona, Benchimol, Eric I., Bernstein, Charles N., Avina-Zubieta, J. Antonio, Bitton, Alain, Carroll, Mathew W., Hazlewood, Glen, Jacobson, Kevan, Jelinski, Susan, Deardon, Rob, Jones, Jennifer L., Kuenzig, M. Ellen, Leddin, Desmond, McBrien, Kerry A., Murthy, Sanjay K., Nguyen, Geoffrey C., Otley, Anthony R., Panaccione, Remo, Rezaie, Ali, Rosenfeld, Greg, Peña-Sánchez, Juan Nicolás, Singh, Harminder, Targownik, Laura E., Kaplan, Gilaad G.

“…Inflammatory bowel diseases (IBDs) exist worldwide, with high prevalence in North America. IBD is complex and costly, and its increasing prevalence places a…”
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Infectious and malignant complications of TNF inhibitor therapy in IBD by Targownik, Laura E, Bernstein, Charles N

“…Tumor necrosis factor (TNF) inhibitors are being increasingly utilized in the management of inflammatory bowel disease (IBD). Although the benefits associated…”
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Higher Incidence of Clostridium difficile Infection Among Individuals With Inflammatory Bowel Disease by Singh, Harminder, MD MPH, Nugent, Zoann, PhD, Yu, B Nancy, PhD, Lix, Lisa M., PhD, Targownik, Laura E., MD, MSHS, Bernstein, Charles N., MD

“…Abstract Background & Aims Studies of Clostridium difficile infections (CDIs) among individuals with inflammatory bowel disease (IBD) have used data from…”
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Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases by Benchimol, Eric I, Bernstein, Charles N, Bitton, Alain, Carroll, Matthew W, Singh, Harminder, Otley, Anthony R, Vutcovici, Maria, El-Matary, Wael, Nguyen, Geoffrey C, Griffiths, Anne M, Mack, David R, Jacobson, Kevan, Mojaverian, Nassim, Tanyingoh, Divine, Cui, Yunsong, Nugent, Zoann J, Coulombe, Janie, Targownik, Laura E, Jones, Jennifer L, Leddin, Desmond, Murthy, Sanjay K, Kaplan, Gilaad G

“…The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine…”
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Surgical Rates for Crohn's Disease are Decreasing: A Population-Based Time Trend Analysis and Validation Study by Ma, Christopher, Moran, Gordon W, Benchimol, Eric I, Targownik, Laura E, Heitman, Steven J, Hubbard, James N, Seow, Cynthia H, Novak, Kerri L, Ghosh, Subrata, Panaccione, Remo, Kaplan, Gilaad G

“…Temporal changes for intestinal resections for Crohn's disease (CD) are controversial. We validated administrative database codes for CD diagnosis and surgery…”
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Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis by Azoulay, Laurent, Filion, Kristian B, Platt, Robert W, Dahl, Matthew, Dormuth, Colin R, Clemens, Kristin K, Durand, Madeleine, Hu, Nianping, Juurlink, David N, Paterson, J Michael, Targownik, Laura E, Turin, Tanvir C, Ernst, Pierre, Suissa, Samy, Hemmelgarn, Brenda R, Teare, Gary F, Caetano, Patricia, Chateau, Dan, Henry, David A, LeLorier, Jacques, Levy, Adrian R, Sketris, Ingrid S

“…The association between incretin-based drugs, such as dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) agonists, and acute…”
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Longitudinal Trends in the Direct Costs and Health Care Utilization Ascribable to Inflammatory Bowel Disease in the Biologic Era: Results From a Canadian Population–Based Analysis by Targownik, Laura E., Kaplan, Gilaad G., Witt, Julia, Bernstein, Charles N., Singh, Harminder, Tennakoon, Aruni, Aviña Zubieta, Antonio, Coward, Stephanie B., Jones, Jennifer, Kuenzig, M. Ellen, Murthy, Sanjay K., Nguyen, Geoffrey C., Peña-Sánchez, Juan Nicolás, Benchimol, Eric I

“…The prevalence of inflammatory bowel disease (IBD) is increasing. The total direct costs of IBD have not been assessed on a population-wide level in the era of…”
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Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003 by Targownik, Laura E, Nabalamba, Alice

“…ANVUGIB is a common reason for hospital admission and has been traditionally associated with a mortality rate of 5%-10%. There have been numerous innovations…”
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Use of proton pump inhibitors and risk of osteoporosis-related fractures by Targownik, Laura E, Lix, Lisa M, Metge, Colleen J, Prior, Heather J, Leung, Stella, Leslie, William D

“…The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between duration of…”
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Performance of administrative case definitions for depression and anxiety in inflammatory bowel disease by Marrie, Ruth Ann, MD, PhD, Walker, John R., PhD, Graff, Lesley A., PhD, Lix, Lisa M, Bolton, James M., MD, Nugent, Zoann, PhD, Targownik, Laura E., MD, MSHS, Bernstein, Charles N., MD

“…Abstract Objectives Comorbid depression and anxiety are common in inflammatory bowel disease (IBD), but few population-based estimates of the burden of…”
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The Effect of Initiation of Anti-TNF Therapy on the Subsequent Direct Health Care Costs of Inflammatory Bowel Disease by Targownik, Laura E, Benchimol, Eric I, Witt, Julia, Bernstein, Charles N, Singh, Harminder, Lix, Lisa, Tennakoon, Aruni, Zubieta, Antonio Aviña, Coward, Stephanie, Jones, Jennifer, Kuenzig, Ellen, Murthy, Sanjay K, Nguyen, Geoffrey C, Peña-Sánchez, Juan Nicolás, Kaplan, Gil

“…Anti-tumor necrosis factor (anti-TNF) drugs are highly effective in the treatment of moderate-to-severe Crohn's disease (CD) and ulcerative colitis (UC), but…”
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The Relationship Between Proton Pump Inhibitor Use and Longitudinal Change in Bone Mineral Density: A Population-Based From the Canadian Multicentre Osteoporosis Study (CaMos) by TARGOWNIK, Laura E, LESLIE, William D, WEI ZHOU, SHAWN DAVISON, K, GOLTZMAN, David, JAMAL, Sophie A, KREIGER, Nancy, JOSSE, Robert G, KAISER, Stephanie M, KOVACS, Christopher S, PRIOR, Jerilynn C

“…OBJECTIVES:Proton pump inhibitor (PPI) use has been identified as a risk factor for hip and vertebral fractures. Evidence supporting a relationship between PPI…”
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Failure to Account for Immortal Person Time Likely Accounts for the Apparent Reduction in Surgery Among Natalizumab Users by Targownik, Laura E., MD, MSHS

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Characterization of inflammatory bowel disease in elderly patients: A review of epidemiology, current practices and outcomes of current management strategies by Stepaniuk, Peter, Bernstein, Charles N, Targownik, Laura E, Singh, Harminder

“…The authors review and summarize the current literature regarding the epidemiology, clinical presentation and management of inflammatory bowel disease (IBD) in…”
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Direct cost of health care for individuals with community associated Clostridium difficile infections: A population-based cohort study by Singh, Harminder, Nugent, Zoann, Walkty, A, Yu, B Nancy, Lix, Lisa M, Targownik, Laura E, Bernstein, Charles N, Witt, Julia

“…Even though the incidence of community-acquired Clostridium difficile infection (CDI) is reported to be increasing, few studies have reported on the healthcare…”
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Inflammatory Bowel Disease Has a Small Effect on Bone Mineral Density and Risk for Osteoporosis by Targownik, Laura E, Bernstein, Charles N, Nugent, Zoann, Leslie, William D

“…Background & Aims A high prevalence of osteoporosis has been reported among individuals with inflammatory bowel disease (IBD). We performed a population-based…”
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Are We Worried Enough About Selective Serotonin Receptor Inhibitors and Upper Gastrointestinal Bleeding? by Targownik, Laura E., MD, MSHS

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The Relative Efficacies of Gastroprotective Strategies in Chronic Users of Nonsteroidal Anti-inflammatory Drugs by Targownik, Laura E, Metge, Colleen J, Leung, Stella, Chateau, Daniel G

“…Background & Aims: There are numerous gastroprotective strategies recommended for reducing the risk of upper gastrointestinal (GI) complications in long-term…”
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