Inhibition of intraerythrocytic development of Plasmodium falciparum by proteinase inhibitors

Inhibition of intraerythrocytic development of Plasmodium falciparum by proteinase inhibitors

A group of inactivators of cysteinyl proteinases which function by covalent bond formation have been examined for their ability to inhibit thedevelopment of Plasmodium falciparum within red blood cells. The most effective of these caused inactivation of the parasite near 10 −8 M concentration. The r...

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Bibliographic Details
Published in:FEBS letters Vol. 259; no. 2; pp. 257 - 259
Main Authors: Rockett, K.A., Playfair, J.H.L., Ashall, F., Target, G.A.T., Angliker, H., Shaw, E.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 1990
Elsevier
Subjects:
Animals
Antimalarial
Biological and medical sciences
Dipeptides - pharmacology
Erythrocytes - parasitology
Fundamental and applied biological sciences. Psychology
Humans
Life cycle. Host-agent relationship. Pathogenesis
Plasmodial inhibition
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Protease Inhibitors - pharmacology
Proteinase inhibitor
Protozoa
Structure-Activity Relationship
Plasmodial inhibition
Antimalarial
Proteinase inhibitor
Human
Infection
Protozoa
Plasmodium falciparum
Proteinase
Development
Red blood cell
Enzyme inhibitor
Inhibition
Sporozoa
Plasmode
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Summary:A group of inactivators of cysteinyl proteinases which function by covalent bond formation have been examined for their ability to inhibit thedevelopment of Plasmodium falciparum within red blood cells. The most effective of these caused inactivation of the parasite near 10 −8 M concentration. The range of inhibitory action varied with peptide structure in a manner characteristic of affinity labels for proteinases suggesting that the target of inhibition was an unidentified proteinase, probably of the cysteinyl type, but different from cathepsins B and L.
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ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(90)80022-B