Search Results - "Tardy, Sébastien"

In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA by Slepikas, Liudas, Chiriano, Gianpaolo, Perozzo, Remo, Tardy, Sébastien, Kranjc, Agata, Patthey-Vuadens, Ophélie, Ouertatani-Sakouhi, Hajer, Kicka, Sébastien, Harrison, Christopher F, Scrignari, Tiziana, Perron, Karl, Hilbi, Hubert, Soldati, Thierry, Cosson, Pierre, Tarasevicius, Eduardas, Scapozza, Leonardo

“…Here, we report on the design, synthesis, and biological evaluation of 4-thiazolidinone (rhodanine) derivatives targeting Mycobacterial tuberculosis (Mtb)…”
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Discovery of Novel α‑Carboline Inhibitors of the Anaplastic Lymphoma Kinase by Mologni, Luca, Tardy, Sébastien, Zambon, Alfonso, Orsato, Alexandre, Bisson, William H., Ceccon, Monica, Viltadi, Michela, D’Attoma, Joseph, Pannilunghi, Sara, Vece, Vito, Bertho, Jerome, Goekjian, Peter, Scapozza, Leonardo, Gambacorti-Passerini, Carlo

“…The anaplastic lymphoma kinase (ALK) is abnormally expressed and hyperactivated in a number of tumors and represents an ideal therapeutic target. Despite…”
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Study of phenoxy radical couplings using the enzymatic secretome of Botrytis cinerea by Huber, Robin, Marcourt, Laurence, Félix, Fabien, Tardy, Sébastien, Michellod, Emilie, Scapozza, Leonardo, Wolfender, Jean-Luc, Gindro, Katia, Queiroz, Emerson Ferreira

“…Phenoxy radical coupling reactions are widely used in nature for the synthesis of complex molecules such as lignin. Their use in the laboratory has great…”
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Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation by Preynat-Seauve, Olivier, Nguyen, Evelyne Bao-Vi, Westermaier, Yvonne, Héritier, Margaux, Tardy, Sébastien, Cambet, Yves, Feyeux, Maxime, Caillon, Aurélie, Scapozza, Leonardo, Krause, Karl-Heinz

“…Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells…”
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Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of Lasiodiplodia venezuelensis by Pellissier, Léonie, Koval, Alexey, Marcourt, Laurence, Ferreira Queiroz, Emerson, Lecoultre, Nicole, Leoni, Sara, Quiros-Guerrero, Luis-Manuel, Barthélémy, Morgane, Duivelshof, Bastiaan L., Guillarme, Davy, Tardy, Sébastien, Eparvier, Véronique, Perron, Karl, Chave, Jérôme, Stien, Didier, Gindro, Katia, Katanaev, Vladimir, Wolfender, Jean-Luc

“…The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in…”
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Correction to “Discovery of Novel α‑Carboline Inhibitors of the Anaplastic Lymphoma Kinase” by Mologni, Luca, Tardy, Sébastien, Zambon, Alfonso, Orsato, Alexandre, Schneider, Cédric, Bisson, William H., Ceccon, Monica, Viltadi, Michela, Goyard, David, Garcia, Pierre, D’Attoma, Joseph, Pannilunghi, Sara, Vece, Vito, Bertho, Jerome, Gueyrard, David, Goekjian, Peter, Scapozza, Leonardo, Gambacorti-Passerini, Carlo

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From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation by Cecchini, Carlotta, Pannilunghi, Sara, Tardy, Sébastien, Scapozza, Leonardo

“…Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome…”
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Linkers as Game-changers in PROTAC Technology: Emphasizing General Trends in PROTAC Pharmacokinetics for their Rational Design by Cecchini, Carlotta, Tardy, Sébastien, Scapozza, Leonardo

“…Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that act as degraders. They selectively remove disease-associated proteins by…”
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Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks by Sotiriou, Sotirios K., Kamileri, Irene, Lugli, Natalia, Evangelou, Konstantinos, Da-Ré, Caterina, Huber, Florian, Padayachy, Laura, Tardy, Sebastien, Nicati, Noemie L., Barriot, Samia, Ochs, Fena, Lukas, Claudia, Lukas, Jiri, Gorgoulis, Vassilis G., Scapozza, Leonardo, Halazonetis, Thanos D.

“…Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as…”
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Exploring the Ubiquitin-Proteasome System (UPS) through PROTAC Technology by Cecchini, Carlotta, Tardy, Sébastien, Ceserani, Valentina, Theurillat, Jean-Philippe, Scapozza, Leonardo

“…In the context of dysregulated ubiquitylation, the accumulation of oncogenic substrates can lead to tumorigenesis. In particular, mutations in Von…”
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Identification of non-ATP-competitive α-carboline inhibitors of the anaplastic lymphoma kinase by Mologni, Luca, Orsato, Alexandre, Zambon, Alfonso, Tardy, Sébastien, Bisson, William H., Schneider, Cedric, Ceccon, Monica, Viltadi, Michela, D'Attoma, Joseph, Pannilunghi, Sara, Vece, Vito, Gueyrard, David, Bertho, Jerome, Scapozza, Leonardo, Goekjian, Peter, Gambacorti-Passerini, Carlo

“…The Anaplastic Lymphoma Kinase (ALK) is a therapeutic target for personalized medicine in selected cancers. Despite excellent clinical responses to ALK…”
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Regioselective N-vinylation of cyclic thionocarbamates through a vinyl bis-sulfone methodology by Girniene, Jolanta, Tardy, Sébastien, Tatibouët, Arnaud, Sačkus, Algirdas, Rollin, Patrick

“…■■■ A vinyl bis-sulfone Michael type approach towards heteroatom vinylation was applied on nitrogen derivatives. Cyclic thionocarbamates––mainly…”
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Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors by Tardy, Sébastien, Orsato, Alexandre, Mologni, Luca, Bisson, William H., Donadoni, Carla, Gambacorti-Passerini, Carlo, Scapozza, Leonardo, Gueyrard, David, Goekjian, Peter G.

“…Novel fused tricyclic heterocycles were prepared as inhibitors of oncogenic fusion proteins of the ALK tyrosine kinase. The best compound was active against wt…”
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1,3-Oxazoline- and 1,3-oxazolidine-2-thiones as substrates in direct modified Stille and Suzuki cross-coupling by Silva, Sandrina, Tardy, Sébastien, Routier, Sylvain, Suzenet, Franck, Tatibouët, Arnaud, Rauter, Amelia P., Rollin, Patrick

“…1,3-Oxazoline- (OXT) and 1,3-oxazolidine-2-thiones (OZT) can undergo direct Stille and Suzuki cross-coupling reactions under microwave activation to produce…”
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Synthesis of Optically Active Monoacid Side-Chains of Cephalotaxus Alkaloids by Berhal, Farouk, Tardy, Sébastien, Pérard-Viret, Joëlle, Royer, Jacques

“…The general preparation of enantiopure monoacid side‐chains of several esters of cephalotaxine is described. The strategy, similar to Weinreb's approach to the…”
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