Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies

The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world. Despite the multitude of high-quality papers describing clinical trials of different vacc...

Full description

Saved in:

Bibliographic Details
Published in:	Emerging microbes & infections Vol. 10; no. 1; pp. 1790 - 1806
Main Authors:	Kozlovskaya, Liubov I., Piniaeva, Anastasia N., Ignatyev, Georgy M., Gordeychuk, Ilya V., Volok, Viktor P., Rogova, Yulia V., Shishova, Anna A., Kovpak, Anastasia A., Ivin, Yury Yu, Antonova, Liliya P., Mefyod, Kirill M., Prokosheva, Lyubov S., Sibirkina, Anna S., Tarasova, Yuliya Yu, Bayurova, Ekaterina O., Gancharova, Olga S., Illarionova, Victoria V., Glukhov, Grigory S., Sokolova, Olga S., Shaitan, Konstantin V., Moysenovich, Anastasia M., Gulyaev, Stanislav A., Gulyaeva, Tatiana V., Moroz, Andrey V., Gmyl, Larissa V., Ipatova, Elena G., Kirpichnikov, Mikhail P., Egorov, Alexey M., Siniugina, Aleksandra A., Ishmukhametov, Aydar A.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01-01-2021 Taylor & Francis Group
Subjects:	Animals Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Callithrix COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - adverse effects COVID-19 Vaccines - immunology Cricetinae Disease Models, Animal Drug Evaluation, Preclinical Female Guinea Pigs Humans Immunity, Humoral immunogenicity Immunogenicity, Vaccine Immunoglobulin G - immunology inactivated vaccine Male Mesocricetus Mice Mice, Inbred BALB C neutralizing antibodies Original preclinical study Rats Rats, Wistar safety SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - immunology Time Factors Vaccine Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - adverse effects Vaccines, Inactivated - immunology COVID-19 SARS-CoV-2 inactivated vaccine safety neutralizing antibodies Vaccine preclinical study immunogenicity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world. Despite the multitude of high-quality papers describing clinical trials of different vaccine products, basic detailed data on general toxicity, reproductive toxicity, immunogenicity, protective efficacy and durability of immune response in animal models are scarce. Here, we developed a β-propiolactone-inactivated whole virion vaccine CoviVac and assessed its safety, protective efficacy, immunogenicity and stability of the immune response in rodents and non-human primates. The vaccine showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity, or teratogenic effects, as well as no allergenic properties in studied animal species. The vaccine induced stable and robust humoral immune response both in form of specific anti-SARS-CoV-2 IgG and NAbs in mice, Syrian hamsters, and common marmosets. The NAb levels did not decrease significantly over the course of one year. The course of two immunizations protected Syrian hamsters from severe pneumonia upon intranasal challenge with the live virus. Robustness of the vaccine manufacturing process was demonstrated as well. These data encouraged further evaluation of CoviVac in clinical trials.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally. Supplemental data for this article can be accessed at https://doi.org/10.1080/22221751.2021.1971569.
ISSN:	2222-1751 2222-1751
DOI:	10.1080/22221751.2021.1971569