Search Results - "Taraska, Justin W."

Generation of nanoscopic membrane curvature for membrane trafficking by Kozlov, Michael M., Taraska, Justin W.

“…Curved membranes are key features of intracellular organelles, and their generation involves dynamic protein complexes. Here we describe the fundamental…”
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From Flat to Curved Clathrin: Controlling a Plastic Ratchet by Sochacki, Kem A., Taraska, Justin W.

“…Clathrin-mediated endocytosis (CME) is the primary mechanism eukaryotic cells use to internalize material. New imaging tools are revealing the nanoscale…”
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Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells by Sochacki, Kem A., Dickey, Andrea M., Strub, Marie-Paule, Taraska, Justin W.

“…Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is…”
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Exosomes released from breast cancer carcinomas stimulate cell movement by Harris, Dinari A, Patel, Sajni H, Gucek, Marjan, Hendrix, An, Westbroek, Wendy, Taraska, Justin W

“…For metastasis to occur cells must communicate with to their local environment to initiate growth and invasion. Exosomes have emerged as an important mediator…”
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Find your coat: Using correlative light and electron microscopy to study intracellular protein coats by Sochacki, Kem A., Taraska, Justin W.

“…Protein coats, important for vesicular trafficking in eukaryotic cells, help shape membranes and package cargo. But their dynamic construction cannot be fully…”
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The role of molecular diffusion within dendritic spines in synaptic function by Obashi, Kazuki, Taraska, Justin W, Okabe, Shigeo

“…Spines are tiny nanoscale protrusions from dendrites of neurons. In the cortex and hippocampus, most of the excitatory postsynaptic sites reside in spines. The…”
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Energy and Dynamics of Caveolae Trafficking by Matthaeus, Claudia, Taraska, Justin W

“…Caveolae are 70-100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped…”
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Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis by Martineau, Magalie, Somasundaram, Agila, Grimm, Jonathan B., Gruber, Todd D., Choquet, Daniel, Taraska, Justin W., Lavis, Luke D., Perrais, David

“…The GFP-based superecliptic pHluorin (SEP) enables detection of exocytosis and endocytosis, but its performance has not been duplicated in red fluorescent…”
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Three-dimensional structured illumination microscopy with enhanced axial resolution by Li, Xuesong, Wu, Yicong, Su, Yijun, Rey-Suarez, Ivan, Matthaeus, Claudia, Updegrove, Taylor B., Wei, Zhuang, Zhang, Lixia, Sasaki, Hideki, Li, Yue, Guo, Min, Giannini, John P., Vishwasrao, Harshad D., Chen, Jiji, Lee, Shih-Jong J., Shao, Lin, Liu, Huafeng, Ramamurthi, Kumaran S., Taraska, Justin W., Upadhyaya, Arpita, La Riviere, Patrick, Shroff, Hari

“…The axial resolution of three-dimensional structured illumination microscopy (3D SIM) is limited to ∼300 nm. Here we present two distinct, complementary…”
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Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis by Bucher, Delia, Frey, Felix, Sochacki, Kem A., Kummer, Susann, Bergeest, Jan-Philip, Godinez, William J., Kräusslich, Hans-Georg, Rohr, Karl, Taraska, Justin W., Schwarz, Ulrich S., Boulant, Steeve

“…Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it…”
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Cryo-EM of the dynamin polymer assembled on lipid membrane by Kong, Leopold, Sochacki, Kem A., Wang, Huaibin, Fang, Shunming, Canagarajah, Bertram, Kehr, Andrew D., Rice, William J., Strub, Marie-Paule, Taraska, Justin W., Hinshaw, Jenny E.

“…Membrane fission is a fundamental process in the regulation and remodelling of cell membranes. Dynamin, a large GTPase, mediates membrane fission by assembling…”
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Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells by Trexler, Adam J., Taraska, Justin W.

“…[Display omitted] •Activation of protein kinase C potentiates insulin secretion from beta cells.•Glucose stimulation produces calcium influx that activates…”
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The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane by Matthaeus, Claudia, Sochacki, Kem A., Dickey, Andrea M., Puchkov, Dmytro, Haucke, Volker, Lehmann, Martin, Taraska, Justin W.

“…Caveolae are small coated plasma membrane invaginations with diverse functions. Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate…”
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Genome-edited human stem cells expressing fluorescently labeled endocytic markers allow quantitative analysis of clathrin-mediated endocytosis during differentiation by Dambournet, Daphné, Sochacki, Kem A, Cheng, Aaron T, Akamatsu, Matthew, Taraska, Justin W, Hockemeyer, Dirk, Drubin, David G

“…We developed a general approach for investigation of how cellular processes become adapted for specific cell types during differentiation. Previous studies…”
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A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells by Obashi, Kazuki, Sochacki, Kem A., Strub, Marie-Paule, Taraska, Justin W.

“…Conformational changes in endocytic proteins are regulators of clathrin-mediated endocytosis. Three clathrin heavy chains associated with clathrin light chains…”
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Cell biology of the future: Nanometer-scale cellular cartography by Taraska, Justin W

“…Understanding cellular structure is key to understanding cellular regulation. New developments in super-resolution fluorescence imaging, electron microscopy,…”
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Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics by Scott, Brandon L., Sochacki, Kem A., Low-Nam, Shalini T., Bailey, Elizabeth M., Luu, QuocAhn, Hor, Amy, Dickey, Andrea M., Smith, Steve, Kerkvliet, Jason G., Taraska, Justin W., Hoppe, Adam D.

“…Clathrin-mediated endocytosis (CME) internalizes plasma membrane by reshaping small regions of the cell surface into spherical vesicles. The key mechanistic…”
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Dual clathrin and integrin signaling systems regulate growth factor receptor activation by Alfonzo-Méndez, Marco A., Sochacki, Kem A., Strub, Marie-Paule, Taraska, Justin W.

“…The crosstalk between growth factor and adhesion receptors is key for cell growth and migration. In pathological settings, these receptors are drivers of…”
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The nanoscale molecular morphology of docked exocytic dense-core vesicles in neuroendocrine cells by Prasai, Bijeta, Haber, Gideon J., Strub, Marie-Paule, Ahn, Regina, Ciemniecki, John A., Sochacki, Kem A., Taraska, Justin W.

“…Rab-GTPases and their interacting partners are key regulators of secretory vesicle trafficking, docking, and fusion to the plasma membrane in neurons and…”
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Eden growth models for flat clathrin lattices with vacancies by Frey, Felix, Bucher, Delia, Sochacki, Kem A, Taraska, Justin W, Boulant, Steeve, Schwarz, Ulrich S

“…Clathrin-mediated endocytosis is one of the major pathways by which cells internalise cargo molecules. Recently it has been shown that clathrin triskelia can…”
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