Search Results - "Tarasiuk, Jolanta"

Antitumour Effects of Selected Pyridinium Salts on Sensitive Leukaemia HL60 Cells and Their Multidrug Resistant Topoisomerase II-Defective HL60/MX2 Counterparts by Tarasiuk, Jolanta, Kostrzewa-Nowak, Dorota, Żwierełło, Wojciech

“…Multidrug resistance (MDR), having a multifactorial nature, is one of the major clinical problems causing the failure of anticancer therapy. The aim of this…”
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In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells by Skupień, Katarzyna, Oszmiański, Jan, Kostrzewa-Nowak, Dorota, Tarasiuk, Jolanta

“…The aim of the present study was to determine in vitro antileukaemic activity of extracts obtained from selected berry plant leaves ( Fragaria x ananassa Duch…”
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Antitumour effects of selected plant polyphenols, gallic acid and ellagic acid, on sensitive and multidrug‐resistant leukaemia HL60 cells by Maruszewska, Agnieszka, Tarasiuk, Jolanta

“…The aim of this study was to examine the antitumour effects of plant phenolic acids, gallic acid (GA) and ellagic acid (EA), on human promyelocytic leukaemia…”
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Quercetin Triggers Induction of Apoptotic and Lysosomal Death of Sensitive and Multidrug Resistant Leukaemia HL60 Cells by Maruszewska, Agnieszka, Tarasiuk, Jolanta

“…Multidrug resistance (MDR) constitutes the major cause of the failure in anticancer therapy. One of the most important mechanisms leading to the occurrence of…”
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Bioreductive Activation of Antitumour Drugs, Doxorubicin and Pirarubicin, Does Not Affect Their Ability to Induce Apoptosis of Sensitive and Multidrug Resistant Leukaemia HL60 Cells by Kostrzewa-Nowak, Dorota, Tarasiuk, Jolanta

“…Clinical significance of antitumour drugs is limited by multidrug resistance (MDR). We examined the effect of bioreductive activation of the anthracyclines,…”
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Comparative effects of selected plant polyphenols, gallic acid and epigallocatechin gallate, on matrix metalloproteinases activity in multidrug resistant MCF7/DOX breast cancer cells by Nowakowska, Anna, Tarasiuk, Jolanta

“…The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase…”
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Invasion and metastasis of tumour cells resistant to chemotherapy by Nowakowska, Anna, Tarasiuk, Jolanta

“…Metastatic tumours resistant to chemotherapy are the major cause of the clinical failure in the treatment of malignant diseases. It is observed often that…”
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Retaining cytotoxic activity of anthrapyridone CO1 against multidrug resistant cells is related to the ability to induce concomitantly apoptosis and lysosomal death of leukaemia HL60/VINC and HL60/DOX cells by Nowak, Robert, Tarasiuk, Jolanta

“…Objectives The effect of anthrapyridone compound CO1 retaining cytotoxic activity against multidrug resistant (MDR) tumour cells on inducing cell death of the…”
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Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase does not change its apoptotic stimuli properties in regard to sensitive and multidrug resistant leukaemia HL60 cells by Kostrzewa-Nowak, Dorota, Tarasiuk, Jolanta

“…The objective of this study was to examine the effect of bioreductive activation of antitumour drug, mitoxantrone (MX), by liver NADPH cytochrome P450…”
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DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells by Żwierełło, Wojciech, Maruszewska, Agnieszka, Nowak, Robert, Kostrzewa-Nowak, Dorota, Tarasiuk, Jolanta

“…Idarubicin (IDA) is one of clinically important anticancer drugs belonging to the anthracycline antibiotic family. The aim of this study was to examine DNA…”
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Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells by Nowak, Robert, Tarasiuk, Jolanta

“…We examined the effect of selected anthraquinone antitumour agents – doxorubicin (DOX), pirarubicin (PIRA) and benzoperimidine BP1 – on inducing apoptosis of…”
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In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells by Skupień, Katarzyna, Kostrzewa-Nowak, Dorota, Oszmiański, Jan, Tarasiuk, Jolanta

“…The aim of the present study was to determine in vitro antileukaemic activities of extracts obtained from chokeberry (Aronia melanocarpa [Michx] Elliot) and…”
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The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells by Kostrzewa-Nowak, Dorota, Bieg, Bohdan, Paine, Mark J.I., Wolf, C. Roland, Tarasiuk, Jolanta

“…Clinical usefulness of anthracyclines belonging to bioreductive antitumour drugs is limited by the occurrence of multidrug resistance (MDR). The aim of this…”
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Effect of selected NAD + analogues on mitochondria activity and proliferation of endothelial EA.hy926 cells by Nowak, Robert, Wrzosek, Antoni, Łukasiak, Agnieszka, Rutkowska, Magdalena, Adamus, Jan, Gębicki, Jerzy, Dołowy, Krzysztof, Szewczyk, Adam, Tarasiuk, Jolanta

“…The aim of the study was to examine the effect of 1-methylnicotinamide (MNA) and 1-methyl-3-nitropyridine (MNP) on mitochondria activity and proliferation of…”
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Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells by Kostrzewa-Nowak, Dorota, Bieg, Bohdan, Paine, Mark J.I, Wolf, C Roland, Tarasiuk, Jolanta

“…The aim of this study was to examine the role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo…”
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The ability of selected pyridinium salts to increase the cytotoxic activity of vincristine but not doxorubicin towards sensitive and multidrug resistant promyelocytic leukaemia HL60 cells by Maruszewska, Agnieszka, Kostrzewa-Nowak, Dorota, Adamus, Jan, Czupryńska, Katarzyna, Maryniak, Dominika, Gebicki, Jerzy, Tarasiuk, Jolanta

“…The aim of this study was to examine the effect of selected pyridinium salts, 1‐methyl‐3‐nitropyridine chloride (MNP+Cl−) and…”
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Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells by Kostrzewa-Nowak, Dorota, Paine, Mark J.I, Korytowska, Anna, Serwatka, Katarzyna, Piotrowska, Sylwia, Wolf, C. Roland, Tarasiuk, Jolanta

“…Abstract The aim of this study was to examine the role of reductive activation of mitoxantrone (MX) by human liver NADPH cytochrome P450 reductase (CPR) in…”
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Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies by Tarasiuk, Jolanta, Mazerski, Jan, Tkaczyk-Gobis, Katarzyna, Borowski, Edward

“…Synthetic antitumor anthracenedione drugs, in contrast to anthracycline antibiotics, are ineffective in free radical formation in NADH dehydrogenase system…”
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The purine nucleotide content in human leukemia cell lines by Baranowska-Bosiacka, Irena, Machaliński, Bogusław, Tarasiuk, Jolanta

“…The HPLC method was used to determine the purine nucleotide (ATP, ADP, AMP, GTP, GDP, GMP, NAD(+)) contents and the values of the adenylate energy charge (AEC)…”
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The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoacridines by Tarasiuk, Jolanta, Majewska, Ewelina, Seksek, Olivier, Rogacka, Dorota, Antonini, Ippolito, Garnier-Suillerot, Arlette, Borowski, Edward

“…The appearance of multidrug resistance (MDR) of tumour cells to a wide array of antitumour drugs, structurally diverse and having different mechanisms of…”
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