Search Results - "Tarashima, Noriko"

Gene Expression of 4′-Thioguanine DNA via 4′-Thiocytosine RNA by Tarashima, Noriko S, Matsuo, Ayako, Minakawa, Noriaki

“…DNA and RNA nucleotides are ubiquitous molecules that store and transmit genetic information. The emergence of synthetic elements that fulfill the function of…”
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Synthesis of a Cyclic Dinucleotide Analogue with Ambiguous Bases, 5‑Aminoimidazole-4-carboxamide by Tarashima, Noriko S, Kumanomido, Yusuke, Nakashima, Katsuyuki, Tanaka, Yoshiyuki, Minakawa, Noriaki

“…Cyclic dinucleotides (CDNs) are second messengers composed of two purine nucleotides. In recent years, the structural diversity of CDNs and their functionality…”
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Rewriting the Central Dogma with Synthetic Genetic Polymers by Saito-Tarashima, Noriko, Murai, Akiho, Minakawa, Noriaki

“…DNA and RNA are ubiquitous molecules responsible for storage and transmission of genetic information and together comprise the central dogma of molecular…”
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Unnatural Base Pairs for Synthetic Biology by Saito-Tarashima, Noriko, Minakawa, Noriaki

“…In this review, we have summarized the research effort into the development of unnatural base pairs beyond standard Watson–Crick (WC) base pairs for synthetic…”
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Replacement of oxygen with sulfur on the furanose ring of cyclic dinucleotides enhances the immunostimulatory effect via STING activation by Saito–Tarashima, Noriko, Kinoshita, Mao, Igata, Yosuke, Kashiwabara, Yuta, Minakawa, Noriaki

“…Cyclic dinucleotides (CDNs) are secondary messengers composed of two purine nucleotides linked via two phosphodiester linkages: c-di-GMP, c-di-AMP,…”
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Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide by Nogi, Yuhei, Saito-Tarashima, Noriko, Karanjit, Sangita, Minakawa, Noriaki

“…5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate (ZMP) is a central intermediate in de novo purine nucleotide biosynthesis. Its nucleobase…”
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Synthesis of oligonucleotides containing 5′-homo-4′-selenouridine derivative and its increased resistance against nuclease by Yu, Jinha, Kim, Ji Won, Chandra, Girish, Saito–Tarashima, Noriko, Nogi, Yuhei, Ota, Masashi, Minakawa, Noriaki, Jeong, Lak Shin

“…[Display omitted] As technologies using RNA or DNA have been developed, various chemical modifications of nucleosides have been attempted to increase the…”
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Chemical Approaches for RNAi Drug Development by Saito-Tarashima, Noriko

“…RNA interference (RNAi) is the standard method of suppressing gene expression because of its target specificity, potency, and ability to silence the expression…”
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Synthesis and Anti-dengue Virus Activity of 5-Ethynylimidazole-4-carboxamide (EICA) Nucleotide Prodrugs by Nakamura, Motoki, Uemura, Kentaro, Saito-Tarashima, Noriko, Sato, Akihiko, Orba, Yasuko, Sawa, Hirofumi, Matsuda, Akira, Maenaka, Katsumi, Minakawa, Noriaki

“…We previously showed that 5-ethynyl-(1-β-D-ribofuranosyl)imidazole-4-carboxamide (1; EICAR) is a potent anti-dengue virus (DENV) compound but is cytotoxic to…”
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Synthesis and Properties of 4'-ThioLNA/BNA by Maeda, Rion, Saito-Tarashima, Noriko, Wakamatsu, Hideaki, Natori, Yoshihiro, Minakawa, Noriaki, Yoshimura, Yuichi

“…To develop a new nucleoside analogue applicable to oligonucleotide therapeutics, we designed a 4'-thio analogue of an LNA/BNA monomer. Synthesis of…”
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Cas9-mediated DNA cleavage guided by enzymatically prepared 4'-thio-modified RNA by Saito-Tarashima, Noriko, Ueno, Mana, Murai, Akiho, Matsuo, Ayako, Minakawa, Noriaki

“…CRISPR-Cas9-mediated DNA editing relies on guide RNAs (gRNAs) that direct site-specific DNA cleavage by the Cas endonuclease. Because natural gRNA is…”
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Synthesis and properties of fully-modified 4′-selenoRNA, an endonuclease-resistant RNA analog by Ota, Masashi, Takahashi, Hiromi, Nogi, Yuhei, Kagotani, Yuma, Saito-Tarashima, Noriko, Kondo, Jiro, Minakawa, Noriaki

“…[Display omitted] A large number of chemically modified oligonucleotides (ONs) have been developed for RNA-based technologies. In most modified RNAs, the…”
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First Synthesis of Fully Modified 4′-SelenoRNA and 2′-OMe-4′-selenoRNA Based on the Mechanistic Considerations of an Unexpected Strand Break by Tarashima, Noriko, Hayashi, Koya, Terasaki, Maki, Taniike, Hirotsugu, Inagaki, Yusuke, Hirose, Kenji, Furukawa, Kazuhiro, Matsuda, Akira, Minakawa, Noriaki

“…This study investigated oligonucleotide (ON) synthesis containing 4′-selenoribonucleoside(s) under standard phosphoramidite conditions. Careful operation using…”
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A practical post-modification synthesis of oligodeoxynucleotides containing 4,7-diaminoimidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidine nucleoside by Tarashima, Noriko, Higuchi, Yosuke, Komatsu, Yasuo, Minakawa, Noriaki

“…We describe herein the practical post-modification synthesis of oligodeoxynucleotides (ODNs) containing 4,7-diaminoimidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidine…”
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Synthesis of 4'-Selenoribonucleosides, the Building Blocks of 4'-SelenoRNA, Using a Hypervalent Iodine by Saito-Tarashima, Noriko, Ota, Masashi, Minakawa, Noriaki

“…Herein is described a detailed protocol for the synthesis of 4'-selenoribonucleoside derivatives that involves the use of a hypervalent iodine species. These…”
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Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents by Okano, Yuki, Saito-Tarashima, Noriko, Kurosawa, Madoka, Iwabu, Ai, Ota, Masashi, Watanabe, Tadashi, Kato, Fumihiro, Hishiki, Takayuki, Fujimuro, Masahiro, Minakawa, Noriaki

“…[Display omitted] In this work, we developed imidazole nucleoside derivatives with anti-dengue virus (DENV) activity was examined. First, compounds in a…”
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Chemistry, Properties, and in Vitro and in Vivo Applications of 2′-O-Methoxyethyl-4′-thioRNA, a Novel Hybrid Type of Chemically Modified RNA by Saito, Yota, Hashimoto, Yosuke, Arai, Mai, Tarashima, Noriko, Miyazawa, Tadashi, Miki, Kazuya, Takahashi, Mayumi, Furukawa, Kazuhiro, Yamazaki, Naoshi, Matsuda, Akira, Ishida, Tatsuhiro, Minakawa, Noriaki

“…We report the synthesis, properties, and in vitro and in vivo applications of 2′‐O‐methoxyethyl‐4′‐thioRNA (MOE‐SRNA), a novel type of hybrid chemically…”
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The novel functional nucleic acid iRed effectively regulates target genes following cytoplasmic delivery by faint electric treatment by Hasan, Mahadi, Tarashima, Noriko, Fujikawa, Koki, Ohgita, Takashi, Hama, Susumu, Tanaka, Tamotsu, Saito, Hiroyuki, Minakawa, Noriaki, Kogure, Kentaro

“…An intelligent shRNA expression device (iRed) contains the minimum essential components needed for shRNA production in cells, and could be a novel tool to…”
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Sofosbuvir Suppresses the Genome Replication of DENV1 in Human Hepatic Huh7 Cells by Kurosawa, Madoka, Kato, Fumihiro, Hishiki, Takayuki, Ito, Saori, Fujisawa, Hiroki, Yamaguchi, Tatsuo, Moriguchi, Misato, Hosokawa, Kohei, Watanabe, Tadashi, Saito-Tarashima, Noriko, Minakawa, Noriaki, Fujimuro, Masahiro

“…Dengue virus (DENV) causes dengue fever and dengue hemorrhagic fever, and DENV infection kills 20,000 people annually worldwide. Therefore, the development of…”
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Synthesis and properties of oligonucleotides containing a 2,6-diamino-3-deazapurine:furanopyrimidine base pair by Matsumoto, Koki, Saito-Tarashima, Noriko, Wada, Tomoya, Yonaha, Orie, Minakawa, Noriaki

“…Furanopyrimidine (FPy) and 2,6-diamino-3-deazapurine (DC 3 Pu) nucleosides with the ability to interact in DDD and AAA H-bonding patterns, respectively, were…”
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