Search Results - "Tarakanova, Vera"

Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism by Lange, Philip T, Lagunoff, Michael, Tarakanova, Vera L

“…Viruses manipulate numerous host factors and cellular pathways to facilitate the replication of viral genomes and the production of infectious progeny. One way…”
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Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection by Kasmani, Moujtaba Y, Zander, Ryan, Chung, H Kay, Chen, Yao, Khatun, Achia, Damo, Martina, Topchyan, Paytsar, Johnson, Kaitlin E, Levashova, Darya, Burns, Robert, Lorenz, Ulrike M, Tarakanova, Vera L, Joshi, Nikhil S, Kaech, Susan M, Cui, Weiguo

“…Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic infection, developmental relationships and mechanisms underlying their…”
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Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection by Xin, Gang, Zander, Ryan, Schauder, David M., Chen, Yao, Weinstein, Jason S., Drobyski, William R., Tarakanova, Vera, Craft, Joseph, Cui, Weiguo

“…During chronic viral infection, the inflammatory function of CD4 T-cells becomes gradually attenuated. Concurrently, Th1 cells progressively acquire the…”
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Nontypeable Haemophilus influenzae challenge during gammaherpesvirus infection enhances viral reactivation and latency by Huss, Nicholas P., Majeed, Sheikh Tahir, Wills, Brandon M., Tarakanova, Vera L., Brockman, Kenneth L., Jondle, Christopher N.

“…Gammaherpesviruses are ubiquitous, lifelong pathogens associated with multiple cancers that infect over 95% of the adult population. Increases in viral…”
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Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime by Johnson, Kaitlin E, Tarakanova, Vera L

“…Gammaherpesviruses are highly prevalent pathogens that establish life-long infection and are associated with diverse malignancies, including…”
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MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob Gene and Additional Loci by Cullum, Emily, Graves, Austin M, Tarakanova, Vera L, Denzin, Lisa K, Golovkina, Tatyana

“…Pathogen-derived peptides are loaded on MHC class II (MHCII) and presented to CD4 T cells for their activation. Peptide loading of MHCII occurs in specialized…”
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Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response by Oleson, Bryndon J., Broniowska, Katarzyna A., Naatz, Aaron, Hogg, Neil, Tarakanova, Vera L., Corbett, John A.

“…Nitric oxide, produced in pancreatic β cells in response to proinflammatory cytokines, plays a dual role in the regulation of β-cell fate. While nitric oxide…”
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Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection by Johansen, Erika R, Schmalzriedt, Damon L, Avila, Danilela, Sylvester, Paul A, Rahlf, Cade R, Bobek, Jordan M, Sahoo, Daisy, Dittel, Bonnie N, Tarakanova, Vera L

“…Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong infection in their hosts and are associated with cancers, including B…”
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Innate immunity and alpha/gammaherpesviruses: first impressions last a lifetime by Jondle, Christopher N, Tarakanova, Vera L

“…Innate immune system is considered the first line of defense during viral invasion, with the wealth of the literature demonstrating innate immune control of…”
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Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses by Darrah, Eric J, Jondle, Christopher N, Johnson, Kaitlin E, Xin, Gang, Lange, Philip T, Cui, Weiguo, Olteanu, Horatiu, Tarakanova, Vera L

“…Gammaherpesviruses are ubiquitous pathogens that are associated with B cell lymphomas. In the early stages of chronic infection, these viruses infect naive B…”
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The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide by Oleson, Bryndon J., Broniowska, Katarzyna A., Yeo, Chay Teng, Flancher, Michael, Naatz, Aaron, Hogg, Neil, Tarakanova, Vera L., Corbett, John A.

“…In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting…”
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Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells by Mboko, Wadzanai P, Mounce, Bryan C, Emmer, Joseph, Darrah, Eric, Patel, Shailendra B, Tarakanova, Vera L

“…Gammaherpesviruses are ubiquitous pathogens that establish a lifelong infection and are associated with cancer. In spite of the high seroprevalence of…”
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Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection by Mboko, Wadzanai P, Rekow, Michaela M, Ledwith, Mitchell P, Lange, Philip T, Schmitz, Kaitlin E, Anderson, Sean, Tarakanova, Vera L

“…Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are associated with a variety of malignancies…”
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ATM supports gammaherpesvirus replication by attenuating type I interferon pathway by Darrah, Eric J., Stoltz, Kyle P., Ledwith, Mitchell, Tarakanova, Vera L.

“…Ataxia-Telangiectasia mutated (ATM) kinase participates in multiple networks, including DNA damage response, oxidative stress, and mitophagy. ATM also supports…”
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Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus by Mboko, Wadzanai P, Olteanu, Horatiu, Ray, Avijit, Xin, Gang, Darrah, Eric J, Kumar, Suresh N, Kulinski, Joseph M, Cui, Weiguo, Dittel, Bonnie N, Gauld, Stephen B, Tarakanova, Vera L

“…Gammaherpesviruses are ubiquitous pathogens that are associated with the development of B cell lymphomas. Gammaherpesviruses employ multiple mechanisms to…”
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STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer by Vonderhaar, Emily P., Barnekow, Nicholas S., McAllister, Donna, McOlash, Laura, Eid, Mahmoud Abu, Riese, Matthew J., Tarakanova, Vera L., Johnson, Bryon D., Dwinell, Michael B.

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor…”
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γ-herpesvirus latency attenuates Mycobacterium tuberculosis infection in mice by Miller, Halli E., Johnson, Kaitlin E., Tarakanova, Vera L., Robinson, Richard T.

“…Tuberculosis is caused by Mycobacterium tuberculosis (Mtb), a bacterial pathogen which is transmitted via aerosol and establishes a chronic lung infection. In…”
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MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection by Dixon, Kate J., Siebert, Jason R., Wang, Dandan, Abel, Alex M., Johnson, Kaitlin E., Riese, Matthew J., Terhune, Scott S., Tarakanova, Vera L., Thakar, Monica S., Malarkannan, Subramaniam

“…•We generated a novel NK cell-specific conditional knockout mouse for MyD88 cKO to define the cell-intrinsic functions of MyD88 in NK cells.•MyD88 cKO mice…”
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Hsp90 Inhibitor 17-DMAG Decreases Expression of Conserved Herpesvirus Protein Kinases and Reduces Virus Production in Epstein-Barr Virus-Infected Cells by Sun, Xiaoping, Bristol, Jillian A, Iwahori, Satoko, Hagemeier, Stacy R, Meng, Qiao, Barlow, Elizabeth A, Fingeroth, Joyce D, Tarakanova, Vera L, Kalejta, Robert F, Kenney, Shannon C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages by Wood, Brent M, Mboko, Wadzanai P, Mounce, Bryan C, Tarakanova, Vera L

“…Abstract Type I interferon (IFN) is a critical antiviral response of the host. We found that Interferon Regulatory Factor 3 (IRF-3) was responsible for…”
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