Search Results - "Tapparelli, Carlo"

Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile by Tapparelli, C, Metternich, R, Ehrhardt, C, Cook, N S

“…Thrombin is a multifunctional protein: in addition to its role in coagulation, thrombin has important biological effects on platelets, endothelial and smooth…”
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High level expression of human apolipoprotein A-I in transgenic rats raises total serum high density lipoprotein cholesterol and lowers rat apolipoprotein A-I by Swanson, M E, Hughes, T E, Denny, I S, France, D S, Paterniti, Jr, J R, Tapparelli, C, Gfeller, P, Bürki, K

“…To examine the consequences of increased apolipoprotein A-I production on cholesterol and lipoprotein metabolism, we have produced two lines of transgenic…”
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Characterization of the P2‘ and P3‘ Specificities of Thrombin Using Fluorescence-Quenched Substrates and Mapping of the Subsites by Mutagenesis by Le Bonniec, Bernard F, Myles, Timothy, Johnson, Tony, Knight, C. Graham, Tapparelli, Carlo, Stone, Stuart R

“…The importance of substrate residues P2‘ and P3‘ on thrombin catalysis has been investigated by comparing the hydrolysis of a series of fluorescence-quenched…”
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Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors by WIENAND, A, EHRHARDT, C, METTERNICH, R, TAPPARELLI, C

“…Based on the structural comparison of the S-1 pocket in different trypsin-like serine proteases, a series of Boc-D-trimethylsilylalanine-proline-boro-X…”
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Characterization of the P 2 ‘ and P 3 ‘ Specificities of Thrombin Using Fluorescence-Quenched Substrates and Mapping of the Subsites by Mutagenesis by Le Bonniec, Bernard F., Myles, Timothy, Johnson, Tony, Knight, C. Graham, Tapparelli, Carlo, Stone, Stuart R.

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Selective boron-Containing thrombin inhibitors—X-ray analysis reveals surprising binding mode by von Matt, Anette, Ehrhardt, Claus, Burkhard, Peter, Metternich, Rainer, Walkinshaw, Malcolm, Tapparelli, Carlo

“…Based on the structural comparison of the S1 pocket in different trypsin-like serine proteases, a series of Boc- d-trimethylsilylalanine-proline-boro-X…”
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Thrombin inhibitors as antithrombotic agents: the importance of rapid inhibition by Stone, S R, Tapparelli, C

“…For use as an antithrombotic agent, a thrombin inhibitor must be potent and specific, i.e., it should not significantly inhibit the proteases of the…”
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Beta-amino acid derivatives as orally active non-peptide fibrinogen receptor antagonists by Kottirsch, Georg, Zerwes, Hans-Günther, Cook, Nigel S., Tapparelli, Carlo

“…The omithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further…”
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In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor by TAPPARELLI, C, METTERNICH, R, EHRHARDT, C, ZURINI, M, CLAESON, G, SCULLY, M. F, STONE, S. R

“…Peptide boronic acid derivatives have proven to be very potent inhibitors of serine proteases with boroarginine derivatives being particularly potent thrombin…”
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Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood: activation by ADP and a thrombin receptor peptide and inhibition by glycoprotein IIb/IIIa antagonists by Cook, N S, Zerwes, H G, Tapparelli, C, Powling, M, Singh, J, Metternich, R, Hagenbach, A

“…Platelet aggregation and fibrinogen binding in whole blood, induced either by ADP or by a 14 amino acid peptide mimicking an N-terminal region of the platelet…”
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Structure and function of thrombin receptors by Tapparelli, C, Metternich, R, Cook, N S

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Antithrombotic activity in vivo of SDZ 217-766, a low-molecular weight thrombin inhibitor in comparison to heparin by Tapparelli, C, Metternich, R, Gfeller, P, Gafner, B, Powling, M

“…Antithrombotic potency of SDZ 217-766, a potent inhibitor of thrombin and other trypsin-like serine proteases, was studied in comparison with heparin in rat…”
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Inhibition of exocytosis by intracellularly applied antibodies against a chromaffin granule-binding protein by Schiweizer, Felix E, Schäfer, Theo, Tapparelli, Carlo, Grob, Marianne, Karli, Urs O, Heumann, Rolf, Thoenen, Hans, Bookman, Richard J, Burger, Max M

“…Exocytotic secretion requires the interaction and fusion of secretory vesicles with the plasma membrane. This process could be mediated by specific recognition…”
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Pharmacological studies on frozen stored canine saphenous veins and basilar arteries by MÜLLER-SCHWEINITZER, E, TAPPARELLI, C

“…Canine saphenous veins were either placed in Krebs-Henseleit solution and stored for 24 h at +4 degrees C, or immersed in FCS (fetal calf serum) containing 1.8…”
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Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients? by Ferrari, M D, Odink, J, Frölich, M, Tapparelli, C, Portielje, J E

“…Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy…”
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Comparison of the actions of serotoninergic agents on human saphenous veins and platelets by Victorzon, M, Tapparelli, C, Müller-Schweinitzer, E

“…Changes in tension of helical strips from human saphenous veins and reversible aggregation of human platelets were recorded in vitro. Comparison of the…”
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Methylergometrine, an active metabolite of methysergide by Müller-Schweinitzer, E, Tapparelli, C

“…In conscious dogs methysergide (MS) caused constriction of the saphenous vein at about 3000 times lower doses than methylergometrine (MT) when infused locally,…”
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Detergents inhibit exocytosis in PC 12 cells: evidence for an effect on ion fluxes by Tapparelli, C, Grob, M, Burger, M M

“…Membrane events in exocytosis were studied by examining the effect of different detergents on the K+-stimulated release of noradrenaline in the secretory cell…”
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Hemodynamic, antivasoconstrictor, and antiatherosclerotic effects of calcium antagonists in animal models of atherosclerosis by Hof, R P, Tapparelli, C, Weinstein, D B

“…Calcium antagonists retard the development of atherosclerosis in cholesterol-fed rabbits and modestly enhance regression after their return to a normal diet…”
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Inhibition of exocytosis by intracellularly applied antibodies against a chromaffin granule-binding protein by Schweizer, Felix E, Schäfer, Theo, Tapparelli, Carlo, Grob, Marianne, Karli, Urs O, Neumann, Rolf, Thoenen, Hans, Bookman, Richard J, Burger, Max M

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