Search Results - "Tapocik, J"

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2 by Barbier, E, Johnstone, A L, Khomtchouk, B B, Tapocik, J D, Pitcairn, C, Rehman, F, Augier, E, Borich, A, Schank, J R, Rienas, C A, Van Booven, D J, Sun, H, Nätt, D, Wahlestedt, C, Heilig, M

“…Epigenetic processes have been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanisms mediating dependence-induced…”
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Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns by Tapocik, J.D., Schank, J.R., Mitchell, J.R., Damazdic, R., Mayo, C.L., Brady, D., Pincus, A.B., King, C.E., Heilig, M., Elmer, G.I.

“…Exposure to traumatic events during childhood increases the risk of adult psychopathology, including anxiety, depression, alcohol use disorders and their…”
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Reprogramming of mPFC transcriptome and function in alcohol dependence by Heilig, M., Barbier, E., Johnstone, A. L., Tapocik, J., Meinhardt, M. W., Pfarr, S., Wahlestedt, C., Sommer, W. H.

“…Despite its limited immediate reinforcement value, alcohol has a potent ability to induce neuroadaptations that promote its incentive salience, escalation of…”
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Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence by Tapocik, J D, Solomon, M, Flanigan, M, Meinhardt, M, Barbier, E, Schank, J R, Schwandt, M, Sommer, W H, Heilig, M

“…Long-term changes in brain gene expression have been identified in alcohol dependence, but underlying mechanisms remain unknown. Here, we examined the…”
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Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training by Augier, E., Flanigan, M., Dulman, R. S., Pincus, A., Schank, J. R., Rice, K.C., Kejun, C., Heilig, M., Tapocik, J. D.

“…Rationale Operant self-administration (SA) is an important model of motivation to consume ethanol (EtOH), but low rates of voluntary consumption in rats are…”
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Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking by Schank, J.R., Nelson, B.S., Damadzic, R., Tapocik, J.D., Yao, M., King, C.E., Rowe, K.E., Cheng, K., Rice, K.C., Heilig, M.

“…Substance P (SP) and its cognate neurokinin-1 receptor (NK1R) are involved in alcohol-related behaviors. We have previously reported that NK1R antagonism…”
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A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats by Thorsell, Annika, Tapocik, Jenica D, Liu, Ke, Zook, Michelle, Bell, Lauren, Flanigan, Meghan, Patnaik, Samarjit, Marugan, Juan, Damadzic, Ruslan, Dehdashti, Seameen J, Schwandt, Melanie L, Southall, Noel, Austin, Christopher P, Eskay, Robert, Ciccocioppo, Roberto, Zheng, Wei, Heilig, Markus

“…The Neuropeptide S receptor, a Gs/Gq-coupled GPCR expressed in brain regions involved in mediating drug reward, has recently emerged as a candidate therapeutic…”
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Epigenetic enzymes as a novel class of targets for disease-modifying pharmacotherapies in alcohol addiction by Barbier, E, Johnstone, A.L, Khomtchouk, B.B, Tapocik, J.D, Pitcairn, C, Rehman, F, Augier, E, Borich, A, Schank, J.R, Rienas, C.A, Van Booven, D.J, Sun, H, Nätt, D, Wahlestedt, C, Heilig, M

“…Conversely, PRDM2 knockdown in non-dependent rats induced a set of gene expression changes that overlapped with those found following alcohol dependence…”
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Dopamine transporter, but not tyrosine hydroxylase, may be implicated in determining individual differences in behavioral sensitization to amphetamine by Dietz, David M., Tapocik, Jenica, Gaval-Cruz, Meriem, Kabbaj, Mohamed

“…Repeated administration of psychostimulants, such as amphetamine and cocaine, results in a long-lasting enhancement of behavioral responses elicited by a…”
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THE IL-1 RECEPTOR INFLUENCES ALCOHOL CONSUMPTION IN C57 MICE by Karlsson, C, Rehman, F, Barbier, E, Salomon, M, Tapocik, J, Thorsell, A, Heilig, M, Schank, JR

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