Search Results - "Tapken, Ines"
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What could be the function of the spinal muscular atrophy-causing protein SMN in macrophages?
Published in Frontiers in immunology (28-05-2024)“…Spinal Muscular Atrophy (SMA), a neurodegenerative disorder, extends its impact beyond the nervous system. The central protein implicated in SMA, Survival…”
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The role of extracellular vesicle fusion with target cells in triggering systemic inflammation
Published in Nature communications (07-02-2024)“…Extracellular vesicles (EVs) play a crucial role in intercellular communication by transferring bioactive molecules from donor to recipient cells. As a result,…”
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A NETWORK-BIOLOGY BASED APPROACH FOR THE EVALUATION OF NOVEL TREATMENT TARGETS FOR SPINAL MUSCULAR ATROPHY (SMA)
Published in IBRO neuroscience reports (01-10-2023)Get full text
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bootGSEA: a bootstrap and rank aggregation pipeline for multi-study and multi-omics enrichment analyses
Published in Frontiers in bioinformatics (03-04-2024)“…Gene set enrichment analysis (GSEA) subsequent to differential expression analysis is a standard step in transcriptomics and proteomics data analysis. Although…”
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Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
Published in Skeletal muscle (28-07-2022)“…Abstract Background Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is…”
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From data to discovery: AI-guided analysis of disease-relevant molecules in spinal muscular atrophy (SMA)
Published in Human molecular genetics (22-07-2024)“…Spinal Muscular Atrophy is caused by partial loss of survival of motoneuron (SMN) protein expression. The numerous interaction partners and mechanisms…”
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The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy
Published in Brain (London, England : 1878) (26-08-2024)“…Monogenic diseases are well-suited paradigms for the causal analysis of disease-driving molecular patterns. Spinal Muscular Atrophy (SMA) is one such monogenic…”
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Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy
Published in Proceedings of the National Academy of Sciences - PNAS (04-05-2021)“…Spinal muscular atrophy (SMA) is a motoneuron disease caused by deletions of the Survival of Motoneuron 1 gene (SMN1) and low SMN protein levels. SMN…”
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