Search Results - "Taoda, Yoshiyuki"

Epigenetic Regulation of Autophagy by the Methyltransferase G9a by Artal-Martinez de Narvajas, Amaia, Gomez, Timothy S., Zhang, Jin-San, Mann, Alexander O., Taoda, Yoshiyuki, Gorman, Jacquelyn A., Herreros-Villanueva, Marta, Gress, Thomas M., Ellenrieder, Volker, Bujanda, Luis, Kim, Do-Hyung, Kozikowski, Alan P., Koenig, Alexander, Billadeau, Daniel D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane by Fujii, Shinya, Masuno, Hiroyuki, Taoda, Yoshiyuki, Kano, Atsushi, Wongmayura, Angsuma, Nakabayashi, Makoto, Ito, Nobutoshi, Shimizu, Masato, Kawachi, Emiko, Hirano, Tomoya, Endo, Yasuyuki, Tanatani, Aya, Kagechika, Hiroyuki

“…We report here the design and synthesis of a novel vitamin D receptor (VDR) agonist whose hydrophobic core structure is p-carborane…”
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Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis by Aoyama, Yasunori, Hakogi, Toshikazu, Fukui, Yuki, Yamada, Daisuke, Ooyama, Takao, Nishino, Yutaka, Shinomoto, Shoji, Nagai, Masahiko, Miyake, Naoki, Taoda, Yoshiyuki, Yoshida, Hiroshi, Yasukata, Tatsuro

“…A practical and scalable synthetic method to obtain dolutegravir sodium (1) was established starting from the readily accessible material maltol (2). This…”
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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore by Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Taishi, Teruhiko, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Fujiwara, Tamio

“…Our group has focused on expanding the scope of a two-metal binding pharmacophore concept to explore HIV-1 integrase inhibitors through medicinal chemistry…”
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Synthesis and structure–activity relationship of p-carborane-based non-secosteroidal vitamin D analogs by Fujii, Shinya, Kano, Atsushi, Songkram, Chalermkiat, Masuno, Hiroyuki, Taoda, Yoshiyuki, Kawachi, Emiko, Hirano, Tomoya, Tanatani, Aya, Kagechika, Hiroyuki

“…1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates…”
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New designs for HIV-1 integrase inhibitors: a patent review (2018-present) by Taoda, Yoshiyuki, Sugiyama, Shuichi, Seki, Takahiro

“…Combination antiretroviral therapy (cART) has dramatically reduced morbidity and mortality of HIV-1-infected patients. Integrase strand transfer inhibitors…”
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Electronic effects of icosahedral carboranes: kinetic evidence for interaction between boron atom and nucleophile in the solvolysis of ( o-carboranyl)benzyl tosylates by Endo, Yasuyuki, Taoda, Yoshiyuki

“…Solvolysis of ( o-, m- and p-carboranyl)benzyl toluene- p-sulfonates substituted at the second carbon atom with a phenyl group bearing a range of substituents…”
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Discovery of S‑217622, a Noncovalent Oral SARS-CoV‑2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19 by Unoh, Yuto, Uehara, Shota, Nakahara, Kenji, Nobori, Haruaki, Yamatsu, Yukiko, Yamamoto, Shiho, Maruyama, Yuki, Taoda, Yoshiyuki, Kasamatsu, Koji, Suto, Takahiro, Kouki, Kensuke, Nakahashi, Atsufumi, Kawashima, Sho, Sanaki, Takao, Toba, Shinsuke, Uemura, Kentaro, Mizutare, Tohru, Ando, Shigeru, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Sato, Takafumi, Kato, Teruhisa, Tachibana, Yuki

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths…”
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Electronic Effects of Icosahedral Carboranes. Retentive Solvolysis of (1,2-Dicarba-c loso-dodecaboran-1-yl)benzyl p-Toluenesulfonates by Endo, Yasuyuki, Sawabe, Takehiko, Taoda, Yoshiyuki

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Structure-activity relationship studies of anti-bunyaviral cap-dependent endonuclease inhibitors by Taoda, Yoshiyuki, Sato, Akihiko, Toba, Shinsuke, Unoh, Yuto, Kawai, Makoto, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi

“…[Display omitted] Bunyaviruses, including the Lassa virus (LASV), are known to cause hemorrhagic fever and have a high fatality rate among hospitalized…”
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Electronic effects of icosahedral carboranes. Friedel-Crafts acylation of 1-phenyl-1,2-, 1,7-, and 1,12-dicarba- closo-dodecaboranes by Endo, Yasuyuki, Taoda, Yoshiyuki

“…Friedel-Crafts acylation of the benzene nucleus of 1-phenyl-1,2-, 1,7- and 1,12-dicarba- closo-dodecaboranes (phenylcarboranes) proceeded in the presence of…”
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Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond by Sugiyama, Shuichi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Iwaki, Tsutomu, Matsuoka, Eriko, Akihisa, Erika, Seki, Takahiro, Yoshinaga, Tomokazu, Kawasuji, Takashi

“…[Display omitted] We have discovered HIV-1 novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a pyridine scaffold forming an intramolecular…”
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Dihydrodibenzothiepine: Promising hydrophobic pharmacophore in the influenza cap-dependent endonuclease inhibitor by Taoda, Yoshiyuki, Miyagawa, Masayoshi, Akiyama, Toshiyuki, Tomita, Kenji, Hasegawa, Yasushi, Yoshida, Ryu, Noshi, Takeshi, Shishido, Takao, Kawai, Makoto

“…[Display omitted] This work describes a set of discovery research studies of an influenza cap-dependent endonuclease (CEN) inhibitor with a carbamoyl pyridone…”
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Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors by Akiyama, Toshiyuki, Johns, Brian A., Taoda, Yoshiyuki, Yoshida, Hiroshi, Taishi, Teruhiko, Kawasuji, Takashi, Murai, Hitoshi, Yoshinaga, Tomokazu, Sato, Akihiko, Seki, Takahiro, Koyama, Mikiko, Miki, Shigeru, Kawauchi-Miki, Shinobu, Kagitani-Suyama, Akemi, Fujiwara, Tamio

“…[Display omitted] Integrase strand transfer inhibitors (INSTIs) are the most prescribed anchor drug in antiretroviral therapy. Today, there is an increasing…”
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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744) by Johns, Brian A, Kawasuji, Takashi, Weatherhead, Jason G, Taishi, Teruhiko, Temelkoff, David P, Yoshida, Hiroshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Jeffrey, Jerry, Foster, Scott A, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Johnson, Matthew N, Garvey, Edward P, Fujiwara, Tamio

“…We report herein the discovery of the human immunodeficiency virus type-1 (HIV-1) integrase inhibitors dolutegravir (S/GSK1349572) (3) and S/GSK1265744 (4)…”
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Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease by Miyagawa, Masayoshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Takaya, Kenji, Takahashi-Kageyama, Chika, Tomita, Kenji, Yasuo, Kazuya, Hattori, Kazunari, Shano, Shinya, Yoshida, Ryu, Shishido, Takao, Yoshinaga, Tomokazu, Sato, Akihiko, Kawai, Makoto

“…The medicinal chemistry and structure–activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent…”
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Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction by Taoda, Yoshiyuki, Akiyama, Toshiyuki, Tomita, Kenji, Fujiwara-Kitamura, Misato, Tamura, Yoshinori, Kawasuji, Takashi, Matsuoka, Eriko, Akihisa, Erika, Seki, Takahiro, Yoshinaga, Tomokazu

“…[Display omitted] We have been conducting exploratory research to develop human immunodeficiency virus type-1 (HIV-1) integrase-LEDGF/p75 allosteric inhibitors…”
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Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses by Toba, Shinsuke, Sato, Akihiko, Kawai, Makoto, Taoda, Yoshiyuki, Unoh, Yuto, Kusakabe, Shinji, Nobori, Haruaki, Uehara, Shota, Uemura, Kentaro, Taniguchi, Keiichi, Kobayashi, Masanori, Noshi, Takeshi, Yoshida, Ryu, Naito, Akira, Shishido, Takao, Maruyama, Junki, Paessler, Slobodan, Carr, Michael J, Hall, William W, Yoshimatsu, Kumiko, Arikawa, Jiro, Matsuno, Keita, Sakoda, Yoshihiro, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Kida, Hiroshi

“…Viral hemorrhagic fevers caused by members of the order comprise endemic and emerging human infections that are significant public health concerns. Despite the…”
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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles by Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Weatherhead, Jason G, Akiyama, Toshiyuki, Taishi, Teruhiko, Taoda, Yoshiyuki, Mikamiyama-Iwata, Minako, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Garvey, Edward P, Fujiwara, Tamio

“…This work is a continuation of our initial discovery of a potent monocyclic carbamoyl pyridone human immunodeficiency virus type-1 (HIV-1) integrase inhibitor…”
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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives by Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Taoda, Yoshiyuki, Hata, Kayoko, Hasegawa, Tsuyoshi, Tada, Yukio, Kurihara, Naoko, Kanda, Yasuhiko, Yagi, Shigenori, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki

“…[Display omitted] •Pyrropyrazolone derivatives as a P2X3 receptor antagonist were synthesized.•The SAR studies were started from hit compound 3 with reference…”
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