Search Results - "Tao, Xin‐Yi"
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The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction
Published in Metabolic engineering (01-01-2020)“…Engineering microbes to produce terpenes from renewable feedstock is a promising alternative to traditional production approaches. Generally, terpenes are not…”
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Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction
Published in Metabolic engineering (01-11-2021)“…Harnessing mitochondria is considered as a promising method for biosynthesis of terpenes due to the adequate supply of acetyl-CoA and redox equivalents in…”
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3
Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene
Published in Journal of agricultural and food chemistry (19-02-2020)“…Squalene has wide applications in the food and pharmaceutical industries. Engineering microbes to produce squalene is a promising alternative for traditional…”
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Engineering Escherichia coli for l‐homoserine production
Published in Journal of basic microbiology (01-02-2023)“…l‐homoserine, a nonprotein amino acid, is used to synthesize many active substances in the industry. Here, to develop a robust l‐homoserine‐producing strain,…”
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One-pot biosynthesis of 7β-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum
Published in Microbial cell factories (09-04-2022)“…7β-hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics…”
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Multi-Object Tracking Algorithm for RGB-D Images Based on Asymmetric Dual Siamese Networks
Published in Sensors (Basel, Switzerland) (25-11-2020)“…Currently, intelligent security systems are widely deployed in indoor buildings to ensure the safety of people in shopping malls, banks, train stations, and…”
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Metabolic engineering of Pichia pastoris for the production of dammarenediol-II
Published in Journal of biotechnology (20-12-2015)“…•Increasing supply and reducing competitive consumption of 2,3-oxidosqualene was used.•A marker-recycling and gene-targeting Cre-lox71/66 system was developed…”
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Boosting the epoxidation of squalene to produce triterpenoids in Saccharomyces cerevisiae
Published in Biotechnology for biofuels (04-05-2023)“…Polycyclic triterpenoids (PTs) are common in plants, and have attracted considerable interest due to their remarkable biological activities. Currently,…”
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Unravelling and engineering an operon involved in the side-chain degradation of sterols in Mycolicibacterium neoaurum for the production of steroid synthons
Published in Biotechnology for biofuels (02-08-2023)“…Harnessing engineered Mycolicibacteria to convert cheap phytosterols into valuable steroid synthons is a basic way in the industry for the production of…”
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10
Establishment of a low‐dosage‐IPTG inducible expression system construction method in Escherichia coli
Published in Journal of basic microbiology (01-09-2018)“…The lac operon is a delicate inducible gene expression element in bacteria. To efficiently induce gene expression, a sufficient dosage of an inducer, usually…”
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RNA-Seq analysis uncovers non-coding small RNA system of Mycobacterium neoaurum in the metabolism of sterols to accumulate steroid intermediates
Published in Microbial cell factories (25-04-2016)“…Understanding the metabolic mechanism of sterols to produce valuable steroid intermediates in mycobacterium by a noncoding small RNA (sRNA) view is still…”
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Engineering Mycolicibacterium neoaurum for the production of antioxidant ergothioneine
Published in Food bioengineering (01-03-2022)“…Ergothioneine (EGT) represents valuable protective functions for humans, but EGT from the diet cannot meet daily requirements. Although the heterologous…”
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13
Multiplexed site-specific genome engineering in Mycolicibacterium neoaurum by Att/Int system
Published in Synthetic and systems biotechnology (01-09-2022)“…Genomic integration of genes and pathway-sized DNA cassettes is often an indispensable way to construct robust and productive microbial cell factories. For…”
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14
Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae
Published in Biotechnology letters (01-04-2022)Get full text
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15
Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry
Published in Journal of enzyme inhibition and medicinal chemistry (01-10-2009)“…Tiliroside was found to inhibit both monophenolase and diphenolase activity of mushroom tyrosinase. The lag time of tyrosine oxidation catalyzed by mushroom…”
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Engineering Saccharomyces cerevisiae for Hyperproduction of β‑Amyrin by Mitigating the Inhibition Effect of Squalene on β‑Amyrin Synthase
Published in Journal of agricultural and food chemistry (12-01-2022)“…The study aims to enhance β-amyrin production in Saccharomyces cerevisiae by peroxisome compartmentalization. First, overaccumulated squalene was determined as…”
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17
Unraveling and engineering the production of 23,24-bisnorcholenic steroids in sterol metabolism
Published in Scientific reports (22-02-2016)“…The catabolism of sterols in mycobacteria is highly important due to its close relevance in the pathogenesis of pathogenic strains and the biotechnological…”
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Engineered 3-Ketosteroid 9a-Hydroxylases in Mycobacterium neoaurum: an Efficient Platform for Production of Steroid Drugs
Published in Applied and environmental microbiology (15-07-2018)“…3-Ketosteroid 9α-hydroxylase (Ksh) consists of a terminal oxygenase (KshA) and a ferredoxin reductase and is indispensable in the cleavage of steroid nucleus…”
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Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae
Published in Biotechnology letters (01-04-2022)“…Patchoulol is a natural sesquiterpene, which is widely used in perfumes and cosmetics. In the work, the mitochondria of S. cerevisiae were engineered for…”
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Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans
Published in Journal of biotechnology (10-01-2019)“…•Heterologous promoters could be converted to powerful promoters in S. lividans.•Ptac*RBS3 showed stronger capacity for gene expression than the PtipA in S…”
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