Search Results - "Tao, Nianjun"

Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER + Breast Cancer Patient-derived Xenograft Models by Bihani, Teeru, Patel, Hitisha K, Arlt, Heike, Tao, Nianjun, Jiang, Hai, Brown, Jeffrey L, Purandare, Dinesh M, Hattersley, Gary, Garner, Fiona

“…Estrogen receptor-positive (ER ) breast cancers are typically treated with endocrine agents, and dependence on the ER pathway is often retained even after…”
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Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors by Patel, Hitisha K, Tao, Nianjun, Lee, Kyung-Min, Huerta, Mariela, Arlt, Heike, Mullarkey, Tara, Troy, Steven, Arteaga, Carlos L, Bihani, Teeru

“…Addition of CDK4/6 inhibitors (CDK4/6i) to endocrine therapy significantly increased progression-free survival, leading to their approval and incorporation…”
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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer by Buck, Elizabeth, Gokhale, Prafulla C, Koujak, Susan, Brown, Eric, Eyzaguirre, Alexandra, Tao, Nianjun, Rosenfeld-Franklin, Maryland, Lerner, Lorena, Chiu, M Isabel, Wild, Robert, Epstein, David, Pachter, Jonathan A, Miglarese, Mark R

“…Insulin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase (RTK) and critical activator of the phosphatidylinositol 3-kinase-AKT pathway…”
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Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver by Tao, Nianjun, Gao, Guang-Ping, Parr, Michael, Johnston, Julie, Baradet, Timothy, Wilson, James M., Barsoum, James, Fawell, Stephen E.

“…Systemic administration of a recombinant adenovirus encoding the human interferon-β gene (H5.110CMVhIFN-β) results in transduction of hepatocytes and…”
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Interferon-β Gene Therapy Inhibits Tumor Formation and Causes Regression of Established Tumors in Immune-Deficient Mice by Qin, Xiao-Qiang, Tao, Nianjun, Dergay, Amie, Moy, Pamela, Fawell, Stephen, Davis, Alan, Wilson, James M., Barsoum, James

“…Despite the potential of type 1 interferons (IFNs) for the treatment of cancer, clinical experience with IFN protein therapy of solid tumors has been…”
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Antibody-Mediated Blockade of Integrin αvβ6Inhibits Tumor Progression In vivo by a Transforming Growth Factor-β-Regulated Mechanism by KOOPMAN VAN AARSEN, Louise A, LEONE, Diane R, SIMON, Kenneth J, HORAN, Gerald S, NIANJUN TAO, GARDNER, Humphrey A, SKELLY, Marilyn M, GOWN, Allen M, THOMAS, Gareth J, WEINREB, Paul H, FAWELL, Stephen E, VIOLETTE, Shelia M, HO, Steffan, DOLINSKI, Brian M, MCCOON, Patricia E, LEPAGE, Doreen J, KELLY, Rebecca, HEANEY, Glenna, RAYHORN, Paul, REID, Carl

“…Abstract The αvβ6 integrin is up-regulated on epithelial malignancies and has been implicated in various aspects of cancer progression. Immunohistochemical…”
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Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients by Lerner, Lorena, Hayes, Teresa G., Tao, Nianjun, Krieger, Brian, Feng, Bin, Wu, Zhenhua, Nicoletti, Richard, Chiu, M. Isabel, Gyuris, Jeno, Garcia, Jose M.

“…Background Cancer‐related weight loss is associated with increased inflammation and decreased survival. The novel inflammatory mediator growth differentiation…”
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Abstract 1441: Induction of cancer cachexia by inflammatory molecules in directed complementation tumor models by Liu, Qing, Lerner, Lorena, Siddiquee, Zakir, Huang, Lucia, Wang, Ruojie, Tao, Nianjun, Krieger, Brian, Chiu, Isabel, Gyuris, Jeno

“…Abstract Cancer cachexia is a complex multi-factorial syndrome characterized by anorexia, body weight loss that is primarily due to the loss of skeletal muscle…”
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Abstract 1153: Effective treatment of cancer associated cachexia by AV-380, a GDF15 inhibitory antibody by Lerner, Lorena, Tao, Nianjun, Krieger, Brian, Nicoletti, Richard, Feng, Bin, Ismail, Nesreen, Winston, William, Zhang, Yanyu, Jiang, Jinwei, Weiler, Solly, Gyuris, Jeno

“…Abstract Background: One of the most lethal and debilitating effects of cancer is the development of cancer-related anorexia-cachexia syndrome (CACS). It…”
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Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism by Van Aarsen, Louise A Koopman, Leone, Diane R, Ho, Steffan, Dolinski, Brian M, McCoon, Patricia E, LePage, Doreen J, Kelly, Rebecca, Heaney, Glenna, Rayhorn, Paul, Reid, Carl, Simon, Kenneth J, Horan, Gerald S, Tao, Nianjun, Gardner, Humphrey A, Skelly, Marilyn M, Gown, Allen M, Thomas, Gareth J, Weinreb, Paul H, Fawell, Stephen E, Violette, Shelia M

“…The alpha(v)beta(6) integrin is up-regulated on epithelial malignancies and has been implicated in various aspects of cancer progression. Immunohistochemical…”
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Abstract 4650: From bench to bedside: are cytokines still relevant biomarkers for staging cancer cachexia by Vigano, Antonio, Lerner, Lorena, Tao, Nianjun, Krieger, Brian, Feng, Bin, Nicoletti, Richard, Liu, Qing, Bai, Ailin, Weng, Zhigang, Alcindor, Thierry, Fuoco, Domenico, Gyuris, Jeno, Chiu, Maria Isabel

“…Abstract Background: We have provided initial evidence1 on the clinical usefulness of the cancer cachexia stages (CCS) proposed by Fearon et al2. However it is…”
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Abstract 3504: Plasma growth differentiating factor-15 (GDF-15) and other inflammatory markers are associated with weight loss and poor prognosis in cancer patients by Lorena, Lerner, Hayes, Teresa, Tao, Nianjun, Krieger, Brian, Feng, Bin, Nicoletti, Richard, Bai, Ailin, Weng, Zhigang, Liu, Qing, Chiu, Maria Isabel, Gyuris, Jeno, Garcia, Jose M.

“…Abstract Background: Cachexia is associated with increased inflammatory markers and decreased survival in cancer. Also, elevated GDF-15 has been associated…”
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Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients: GDF15 in cancer-related weight loss by Lerner, Lorena, Hayes, Teresa G., Tao, Nianjun, Krieger, Brian, Feng, Bin, Wu, Zhenhua, Nicoletti, Richard, Chiu, M. Isabel, Gyuris, Jeno, Garcia, Jose M.

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Abstract 1631: Tumorigenicity of IGF-1R and IR: Rationale for co-targeting IGF-1R and IR in cancer by Lerner, Lorena, Liu, Qing, Tao, Nianjun, Yang, John, Brown, Eric, Koujak, Susan, Krieger, Brian, Huang, Lu, Rosenfeld-Franklin, Maryland, Miglarese, Mark, Pachter, Jonathan, Robinson, Murray O., Chiu, M. Isabel, Epstein, David, Buck, Elizabeth

“…Abstract The Type 1 insulin-like growth factor receptor (IGF-1R) is a well established mediator of tumor cell proliferation and survival. IGF-1R is required…”
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Abstract 646: Identification of FURIN as a tumor maintenance gene in solid tumors by in vivo Retroviral Mutagenesis and Directed Complementation by Lorena, Lerner, Liu, Qing, Yang, John, Krieger, Brian, Tao, Nianjun, Zarycki, Jodi, You, Fanglei, Kabbarah, Omar, Robinson, Murray O., Chiu, M. Isabel

“…Abstract To identify tumor maintenance genes and pathways, we applied a genome-wide, large-scale functional screening approach using retrovirus-mediated…”
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Abstract A233: Generation of in vitro and in vivo tumor models driven by insulin-like growth factor receptor (IGF1R) and their use in the development of OSI-906, a selective IGF1R inhibitor by Liu, Qing, Lorena, Lerner, Tao, Nianjun, Huang, Lu, Yang, John, Krieger, Brian, Buck, Elizabeth, Wang, Ruojie, Kannan, Karuppiah, Chiu, M. Isabel, Robinson, Murray O.

“…Abstract The emergence of insulin-like growth factor-1 receptor IGF1R as an important cancer target is evidenced by the growing number of clinical trials…”
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Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant by Wakasugi, Keisuke, Quinn, Cheryl L, Tao, Nianjun, Schimmel, Paul

“…The genetic code is established in aminoacylation reactions whereby amino acids are joined to tRNAs bearing the anticodons of the genetic code. Paradoxically,…”
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Antibody-Mediated Blockade of Integrin alpha sub(v) beta sub(6) Inhibits Tumor Progression In vivo by a Transforming Growth Factor- beta -Regulated Mechanism by Koopman Van Aarsen, Louise A, Leone, Diane R, Ho, Steffan, Dolinski, Brian M, McCoon, Patricia E, LePage, Doreen J, Kelly, Rebecca, Heaney, Glenna, Rayhorn, Paul, Reid, Carl, Simon, Kenneth J, Horan, Gerald S, Tao, Nianjun, Gardner, Humphrey A, Skelly, Marilyn M, Gown, Allen M, Thomas, Gareth J, Weinreb, Paul H, Fawell, Stephen E, Violette, Shelia M

“…The alpha sub(v) beta sub(6) integrin is up-regulated on epithelial malignancies and has been implicated in various aspects of cancer progression…”
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Cloning and Expression of a Gene Encoding an Integrin-Like Protein in Candida albicans by Gale, Cheryl, Finkel, David, Tao, Nianjun, Meinke, Marilyn, McClellan, Mark, Olson, Jennifer, Kendrick, Kathleen, Hostetter, Margaret

“…The existence of integrin-like proteins in Candida albicans has been postulated because monoclonal antibodies to the leukocyte integrins α M and α X bind to…”
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Species-specific microhelix aminoacylation by a eukaryotic pathogen tRNA synthetase dependent on a single base pair by Quinn, Cheryl L, Tao, Nianjun, Schimmel, Paul

“…We report here that tyrosyl-tRNA synthetase from the eukaryotic pathogen Pneumocystis carinii is a 370 amino acid polypeptide with characteristic elements of a…”
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