Search Results - "Tao, Lijian "
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Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation
Published in Biochemical and biophysical research communications (05-07-2020)“…Septic shock induced by lipopolysaccharide (LPS) is characterized by serious systemic inflammatory response and robust production of pro-inflammatory cytokines…”
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2
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
Published in Frontiers in immunology (01-02-2018)“…Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and…”
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3
Transformation of the education of health professionals in China: progress and challenges
Published in The Lancet (British edition) (30-08-2014)“…Summary In this Review we examine the progress and challenges of China's ambitious 1998 reform of the world's largest health professional educational system…”
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Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia
Published in The Journal of experimental medicine (06-04-2020)“…Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains…”
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Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide-Dependent Mechanism
Published in Diabetes (New York, N.Y.) (01-04-2012)“…Glucagon-like peptide 1 (GLP-1) increases tissue glucose uptake and causes vasodilation independent of insulin. We examined the effect of GLP-1 on muscle…”
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Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation
Published in Free radical biology & medicine (01-06-2019)“…Sterile inflammation is initiated by damage-associated molecular patterns (DAMPs) and a key contributor to acute liver injury (ALI). However, the current…”
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Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
Published in Journal of translational medicine (15-03-2019)“…Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation,…”
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Kokusaginine attenuates renal fibrosis by inhibiting the PI3K/AKT signaling pathway
Published in Biomedicine & pharmacotherapy (01-06-2024)“…Kokusaginine is an active ingredient alkaloid that has been isolated and extracted from Ruta graveolens L. Some researches have indicated that alkaloids…”
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Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage
Published in Hypertension (Dallas, Tex. 1979) (01-01-2012)“…Chronic kidney disease (CKD) is a prevalent life-threatening disease frequently associated with hypertension, progression to renal fibrosis, and eventual renal…”
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The prognostic value of triglyceride-glucose index to adverse renal outcomes in patients with type 2 diabetes mellitus: results from the cohort study of ACCORD
Published in Diabetology and metabolic syndrome (19-08-2024)“…The triglyceride-glucose (TyG) index is a new and good biomarker of insulin resistance (IR). The prognostic utility of the TyG index for patients with type 2…”
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11
Targeting CBLB as a potential therapeutic approach for disseminated candidiasis
Published in Nature medicine (01-08-2016)“…Jian Zhang and colleagues identify the E3 ubiquitin ligase CBLB as a major inhibitor of host defense against Candida albicans infection and show that targeting…”
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12
Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis
Published in Scientific reports (22-06-2024)“…Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes of energy…”
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13
Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and Metastasis
Published in Translational oncology (01-02-2019)“…IQGAP2 was recently reported as a tumor suppressor of prostate cancer (PC). Nonetheless, its clinical implications remain unknown. To address this issue, we…”
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14
Identification of Hub Genes Associated With Clear Cell Renal Cell Carcinoma by Integrated Bioinformatics Analysis
Published in Frontiers in oncology (30-09-2021)“…Clear cell renal cell carcinoma (ccRCC) is a common genitourinary cancer type with a high mortality rate. Due to a diverse range of biochemical alterations and…”
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Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages
Published in Biomedicine & pharmacotherapy (01-09-2024)“…Silicosis is the most common and severe type of pneumoconiosis, imposing a substantial disease burden and economic loss on patients and society. The…”
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Fluorofenidone protects against acute kidney injury
Published in The FASEB journal (01-12-2019)“…Cisplatin (CP) is one of the most effective chemotherapeutics in the treatment of human cancers. However, the beneficial effects of CP are limited by the toxic…”
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Machine learning for the prediction of all-cause mortality in patients with sepsis-associated acute kidney injury during hospitalization
Published in Frontiers in immunology (03-04-2023)“…Sepsis-associated acute kidney injury (S-AKI) is considered to be associated with high morbidity and mortality, a commonly accepted model to predict mortality…”
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Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
Published in Cellular signalling (01-11-2010)“…The MEK–ERK pathway plays a role in DNA damage response (DDR). This has been thoroughly studied by modulating MEK activation. However, much less has been done…”
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Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway
Published in Biomedicine & pharmacotherapy (01-08-2023)“…Acute liver failure (ALF) is a life-threatening disease characterized by abrupt and extensive hepatic necrosis and apoptosis, resulting in high mortality. The…”
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AKF-PD alleviates diabetic nephropathy via blocking the RAGE/AGEs/NOX and PKC/NOX Pathways
Published in Scientific reports (13-03-2019)“…Diabetic nephropathy (DN) is a major complication of diabetes. Currently, drugs are not available to effectively control the disease. Fluorofenidone (AKF-PD)…”
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