Search Results - "Tao, Hongrui"

Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations by Tao, Hongrui, Yan, Xue, Zhu, Kongkai, Zhang, Hua

“…As an important epigenetics related enzyme, protein arginine methyltransferase 5 (PRMT5) has been confirmed as an anticancer therapeutic target in recent…”
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Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED–EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations by Zhu, Kongkai, Du, Daohai, Yang, Rui, Tao, Hongrui, Zhang, Hua

“…Polycomb repressive complex 2 (PRC2) is an attractive drug target for anti-cancer treatment. Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2…”
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Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations by Zhu, Kongkai, Jiang, Chengshi, Tao, Hongrui, Liu, Jingqiu, Zhang, Hua, Luo, Cheng

“…[Display omitted] As one of the most promising anticancer target in protein arginine methyltransferase (PRMT) family, PRMT5 has been drawing more and more…”
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Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation by Liu, Shan-Kui, Hao, Haifang, Bian, Yuan, Ge, Yong-Xi, Lu, Shengyuan, Xie, Hong-Xu, Wang, Kai-Ming, Tao, Hongrui, Yuan, Chao, Zhang, Juan, Zhang, Jie, Jiang, Cheng-Shi, Zhu, Kongkai

“…α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and promote glucose conversion, which have been used for the treatment of…”
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Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations by Zhu, Kongkai, Tao, Hongrui, Song, Jia-Li, Jin, Lu, Zhang, Yuanyuan, Liu, Jingqiu, Chen, Zhifeng, Jiang, Cheng-Shi, Luo, Cheng, Zhang, Hua

“…[Display omitted] •A class of PRMT5 inhibitors with the IC50 values ranging from 0.77 to 23 μM were identified.•The structure-activity relationship (SAR) of…”
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Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation by Shao, Jingwei, Zhu, Kongkai, Du, Daohai, Zhang, Yuanyuan, Tao, Hongrui, Chen, Zhifeng, Jiang, Hualiang, Chen, Kaixian, Luo, Cheng, Duan, Wenhu

“…Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a…”
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Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity by Zhu, Kongkai, Shao, Jingwei, Tao, Hongrui, Yan, Xue, Luo, Cheng, Zhang, Hua, Duan, Wenhu

“…Protein arginine methyltransferase 5 (PRMT5) is responsible for the mono-methylation and symmetric dimethylation of arginine, and its expression level and…”
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Identification and assessments of novel and potent small-molecule inhibitors of EED-EZH2 interaction of polycomb repressive complex 2 by computational methods and biological evaluations by Zhu, Kongkai, Du, Daohai, Yang, Rui, Tao, Hongrui, Zhang, Hua

“…Polycomb repressive complex 2 (PRC2) is an attractive drug target for anti-cancer treatment. Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2…”
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Asperbutenolide A, an unusual aromatic butenolide dimer with diverse bioactivities from a marine-derived fungus Aspergillus terreus SCAU011 by Bao, Jie, Li, Xiu-Xiu, He, Fei, Zhang, Xiaoyong, Zhu, Kongkai, Tao, Hongrui, Yu, Jin-Hai, Liu, Haishan, Zhang, Hua

“…[Display omitted] •Two new aromatic butenolide derivatives were obtained from a mangrove sediment derived Aspergillus fungus.•Asperbutenolide A (2) was an…”
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Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods by Zhu, Kongkai, Jiang, Cheng-Shi, Hu, Junchi, Liu, Xigong, Yan, Xue, Tao, Hongrui, Luo, Cheng, Zhang, Hua

“…Protein arginine methyltransferase 5 (PRMT5) is the most promising anticancer target in PRMT family. In this study, based on the first S-adenosylmethionine…”
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