Search Results - "Tanzer, Andrea"
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GENCODE: the reference human genome annotation for The ENCODE Project
Published in Genome research (01-09-2012)“…The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and…”
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RNA modifications in structure prediction – Status quo and future challenges
Published in Methods (San Diego, Calif.) (01-03-2019)“…•Review on RNA modifications (I,Y,m6A) in the light of RNA structures.•Modification requires substrate structures.•Consequences of RNA modification on…”
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3
multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection
Published in Genome biology (10-02-2014)“…Numerous high-throughput sequencing studies have focused on detecting conventionally spliced mRNAs in RNA-seq data. However, non-standard RNAs arising through…”
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Predicting RNA secondary structures from sequence and probing data
Published in Methods (San Diego, Calif.) (01-07-2016)“…•An introduction to algorithms for the prediction of RNA secondary structures is given.•State of the art methods for consensus structures, RNA-RNA…”
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Control of Cognate Sense mRNA Translation by cis-Natural Antisense RNAs
Published in Plant physiology (Bethesda) (01-05-2019)“…Cis-Natural Antisense Transcripts (cis-NATs), which overlap protein coding genes and are transcribed from the opposite DNA strand, constitute an important…”
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Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution
Published in Molecular systems biology (01-05-2016)“…Precise regulation of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. However, a global model integrating…”
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Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome
Published in Science (American Association for the Advancement of Science) (19-10-2007)“…Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inversions, and complex combinations of…”
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Extension of human lncRNA transcripts by RACE coupled with long-read high-throughput sequencing (RACE-Seq)
Published in Nature communications (17-08-2016)“…Long non-coding RNAs (lncRNAs) constitute a large, yet mostly uncharacterized fraction of the mammalian transcriptome. Such characterization requires a…”
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A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation
Published in PLoS genetics (22-08-2022)“…The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are…”
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Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression
Published in Nature communications (13-01-2015)“…Mice have been a long-standing model for human biology and disease. Here we characterize, by RNA sequencing, the transcriptional profiles of a large and…”
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Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library
Published in Nature biotechnology (2010)“…Sequencing a person's genome may reveal large DNA insertions and other structural rearrangements, but assessing their effects requires pinpointing them to…”
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Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells
Published in Scientific reports (07-10-2016)“…The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the…”
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13
The expansion of the metazoan microRNA repertoire
Published in BMC genomics (15-02-2006)“…MicroRNAs have been identified as crucial regulators in both animals and plants. Here we report on a comprehensive comparative study of all known miRNA…”
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Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Published in Proceedings of the National Academy of Sciences - PNAS (30-09-2008)“…Evolutionary change in gene regulation can result from changes in cis-regulatory elements, leading to differences in the temporal and spatial expression of…”
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Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome
Published in Genome research (01-09-2012)“…Within the ENCODE Consortium, GENCODE aimed to accurately annotate all protein-coding genes, pseudogenes, and noncoding transcribed loci in the human genome…”
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Evolution of microRNAs located within Hox gene clusters
Published in Journal of experimental zoology. Part B, Molecular and developmental evolution (15-01-2005)“…MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular…”
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Animal snoRNAs and scaRNAs with exceptional structures
Published in RNA biology (01-11-2011)“…The overwhelming majority of small nucleolar RNAs (snoRNAs) fall into two clearly defined classes characterized by distinctive secondary structures and sequence…”
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RNAs everywhere: genome-wide annotation of structured RNAs
Published in Journal of experimental zoology. Part B, Molecular and developmental evolution (15-01-2007)“…Starting with the discovery of microRNAs and the advent of genome‐wide transcriptomics, non‐protein‐coding transcripts have moved from a fringe topic to a…”
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Comparative promoter region analysis powered by CORG
Published in BMC genomics (21-02-2005)“…Promoters are key players in gene regulation. They receive signals from various sources (e.g. cell surface receptors) and control the level of transcription…”
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AREsite2: an enhanced database for the comprehensive investigation of AU/GU/U-rich elements
Published in Nucleic acids research (04-01-2016)“…AREsite2 represents an update for AREsite, an on-line resource for the investigation of AU-rich elements (ARE) in human and mouse mRNA 3'UTR sequences. The new…”
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