Search Results - "Tantisira, KG"

DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics by Wang, Alberta L., Gruzieva, Olena, Qiu, Weiliang, Kebede Merid, Simon, Celedón, Juan C., Raby, Benjamin A., Söderhäll, Cilla, DeMeo, Dawn L., Weiss, Scott T., Melén, Erik, Tantisira, Kelan G.

“…Background Response to inhaled corticosteroids is highly variable, and the association between DNA methylation and treatment response is not known. Objective…”
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17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use by Farzan, N., Vijverberg, S. J., Hernandez‐Pacheco, N., Bel, E. H. D., Berce, V., Bønnelykke, K., Bisgaard, H., Burchard, E. G., Canino, G., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Forno, E., Francis, B., Hawcutt, D. B., Herrera‐Luis, E., Kabesch, M., Karimi, L., Melén, E., Mukhopadhyay, S., Merid, S. K., Palmer, C. N., Pino‐Yanes, M., Pirmohamed, M., Potočnik, U., Repnik, K., Schieck, M., Sevelsted, A., Sio, Y. Y., Smyth, R. L., Soares, P., Söderhäll, C., Tantisira, K. G., Tavendale, R., Tse, S. M., Turner, S., Verhamme, K. M., Maitland‐van der Zee, A.‐H.

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Influence of Leukotriene Pathway Polymorphisms on Response to Montelukast in Asthma by Lima, John J, Zhang, Shu, Grant, Audrey, Shao, Lianhe, Tantisira, Kelan G, Allayee, Hooman, Wang, Jianwei, Sylvester, James, Holbrook, Janet, Wise, Robert, Weiss, Scott T, Barnes, Kathleen

“…Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes. To determine associations between…”
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Complex interactions in complex traits: obesity and asthma by Tantisira, K G, Weiss, S T

“…Comparing the highest to the lowest quintile of BMI, the relative risk of asthma during that time was 2.3 (95% CI 1.3 to 4.1) in boys and 1.5 (95% CI 0.9 to…”
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Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids by Tantisira, Kelan G., Lake, Stephen, Silverman, Eric S., Palmer, Lyle J., Lazarus, Ross, Silverman, Edwin K., Liggett, Stephen B., Gelfand, Erwin W., Rosenwasser, Lanny J., Richter, Brent, Israel, Elliot, Wechsler, Michael, Gabriel, Stacey, Altshuler, David, Lander, Eric, Drazen, Jeffrey, Weiss, Scott T.

“…Corticosteroids mediate a variety of immunological actions and are commonly utilized in the treatment of a wide range of diseases. Unfortunately, therapy with…”
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Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium by Farzan, Niloufar, Vijverberg, Susanne J, Andiappan, Anand K, Arianto, Lambang, Berce, Vojko, Blanca-López, Natalia, Bisgaard, Hans, Bønnelykke, Klaus, Burchard, Esteban G, Campo, Paloma, Canino, Glorisa, Carleton, Bruce, Celedón, Juan C, Chew, Fook Tim, Chiang, Wen Chin, Cloutier, Michelle M, Daley, Denis, Den Dekker, Herman T, Dijk, F Nicole, Duijts, Liesbeth, Flores, Carlos, Forno, Erick, Hawcutt, Daniel B, Hernandez-Pacheco, Natalia, de Jongste, Johan C, Kabesch, Michael, Koppelman, Gerard H, Manolopoulos, Vangelis G, Melén, Erik, Mukhopadhyay, Somnath, Nilsson, Sara, Palmer, Colin N, Pino-Yanes, Maria, Pirmohamed, Munir, Poto nki, Uros, Raaijmakers, Jan A, Repnik, Katja, Schieck, Maximilian, Sio, Yang Yie, Smyth, Rosalind L, Szalai, Csaba, Tantisira, Kelan G, Turner, Steve, van der Schee, Marc P, Verhamme, Katia M, Maitland-van der Zee, Anke H

“…International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics…”
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Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP) by Tantisira, K G, Litonjua, A A, Weiss, S T, Fuhlbrigge, A L

“…Background: While increases in body mass index (BMI) have been associated with the incidence and prevalence of asthma, the mechanisms behind this association…”
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TBX21: A Functional Variant Predicts Improvement in Asthma with the Use of Inhaled Corticosteroids by Tantisira, Kelan G, Hwang, Eun Sook, Raby, Benjamin A, Silverman, Eric S, Lake, Stephen L, Richter, Brent G, Peng, Stanford L, Drazen, Jeffrey M, Glimcher, Laurie H, Weiss, Scott T

“…TBX21 encodes for the transcription factor T-bet (T-box expressed in T cells), which influences naïve T lymphocyte development and has been implicated in…”
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Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans by LICINIO, J, O'KIRWAN, F, IRIZARRY, K, MERRIMAN, B, THAKUR, S, JEPSON, R, LAKE, S, TANTISIRA, K. G, WEISS, S. T, WONG, M.-L

“…There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH…”
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Expression analysis of asthma candidate genes during human and murine lung development by Melén, Erik, Kho, Alvin T, Sharma, Sunita, Gaedigk, Roger, Leeder, J Steven, Mariani, Thomas J, Carey, Vincent J, Weiss, Scott T, Tantisira, Kelan G

“…Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only…”
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Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma by Tantisira, Kelan G, Lazarus, Ross, Litonjua, Augusto A, Klanderman, Barbara, Weiss, Scott T

“…A 900-kb inversion exists within a large region of conserved linkage disequilibrium (LD) on chromosome 17. CRHR1 is located within the inversion region and…”
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Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program by Sharma, Sunita, MD, Litonjua, Augusto A., MD, Tantisira, Kelan G., MD, Fuhlbrigge, Anne L., MD, Szefler, Stanley J., MD, Strunk, Robert C., MD, Zeiger, Robert S., MD, PhD, Murphy, Amy J., PhD, Weiss, Scott T., MD, MS

“…Background Among asthmatic subjects, bronchodilator response (BDR) to inhaled β2 -adrenergic agonists is variable, and the significance of a consistent…”
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Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma by Hernandez-Pacheco, Natalia, Gorenjak, Mario, Li, Jiang, Repnik, Katja, Vijverberg, Susanne J., Berce, Vojko, Jorgensen, Andrea, Karimi, Leila, Schieck, Maximilian, Samedy-Bates, Lesly-Anne, Tavendale, Roger, Villar, Jesús, Mukhopadhyay, Somnath, Pirmohamed, Munir, Verhamme, Katia M. C., Kabesch, Michael, Hawcutt, Daniel B., Turner, Steve, Palmer, Colin N., Tantisira, Kelan G., Burchard, Esteban G., Maitland-van der Zee, Anke H., Flores, Carlos, Potočnik, Uroš, Pino-Yanes, Maria

“…Inhaled corticosteroids (ICS) are the most common asthma controller medication. An important contribution of genetic factors in ICS response has been…”
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Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between β-agonist and corticosteroid pathways by Tantisira, Kelan G., Small, Kersten M., Litonjua, Augusto A., Weiss, Scott T., Liggett, Stephen B.

“…In asthma, the response to β-agonists acting at β2-adrenergic receptors (β2AR) displays extensive interindividual variation. One effector for airway β2AR,…”
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Association of defensin β-1 gene polymorphisms with asthma by Levy, Hara, Raby, Benjamin A., Lake, Stephen, Tantisira, Kelan G., Kwiatkowski, David, Lazarus, Ross, Silverman, Edwin K., Richter, Brent, Klimecki, Walter T., Vercelli, Donata, Martinez, Fernando D., Weiss, Scott T.

“…Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness. We characterized the genetic diversity in the defensin…”
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The natural history of methacholine responsivenesss in the CAMP study: who becomes unresponsive? by Hopp, Russell J, Stokes, Jefferey R

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17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium by Farzan, N, Vijverberg, SJ, Hernandez-Pacheco, N, Berce, V, Burchard, EG, Canino, G, Celedon, JC, Cloutier, MM, Forno, E, Francis, B, Hawcutt, DB, Kabesch, M, Karimi, L, Melen, E, Mukhopadhyay, S, Nilsson, S, Palmer, CN, Pino-Yanes, M, Pirmohamed, M, Potocnik, U, Raaijmakers, JA, Repnik, K, Schieck, M, Smyth, RL, Tantisira, KG, Tavendale, R, Tse, SM, Turner, S, Verhamme, KM, Maitland-Van der Zee, AH

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Defining uncontrolled childhood asthma in the global PiCA consortium by Farzan, N, Vijverberg, SJ, Andiappan, A, Palmer, CJ, Tantisira, KG, Duijts, L, Pino-Yanes, M, Melen, E, Hawcutt, D, Verhamme, KM, Flores, C, Daley, D, Mukhopadhyay, S, Chew, FT, Bonnelykke, K, Manolopoulos, VG, Kabesch, M, Koppelman, GH, Potocnik, U, Carleton, B, Turner, S, Raaijmakers, J, Maitland-Van Der Zee, AH

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Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ by Gold, Diane R., Willwerth, Ben M., Tantisira, Kelan G., Finn, Patricia W., Schaub, Bianca, Perkins, David L., Tzianabos, Arthur, Ly, Ngoc P., Schroeter, Christian, Gibbons, Fiona, Campos, Hannia, Oken, Emily, Gillman, Matthew W., Palmer, Lyle J., Ryan, Louise M., Weiss, Scott T.

“…N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk…”
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An Elevated Breathing Reserve Index at the Lactate Threshold Is a Predictor of Mortality in Patients with Cystic Fibrosis Awaiting Lung Transplantation by Tantisira, Kelan G, Systrom, David M, Ginns, Leo C

“…The proportion of cystic fibrosis (CF) patients dying while on the lung transplant wait list remains high; identification of such patients remains difficult…”
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