Search Results - "Tantin, Dean R"

Targeting transcription cofactor OCA-B specifically blocks pancreatic T cell infiltration, cytokine production and elevated glucose in the NOD mouse model of type-1 diabetes (T1D) by Tantin, Dean R., Kim, Heejoo

“…Abstract Type 1 Diabetes (T1D) is an autoimmune disease in which the host immune system is misdirected towards antigens associated with beta cells of the…”
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Transcription coactivator OCA-B/Pou2af1 is necessary and sufficient to promote T cell-intrinsic CD4 memory by Tantin, Dean R, Sun, Wenxiang, Kim, Heejoo, Perovanovic, Jelena, Ibarra, Andrea, Hale, J. Scott, Williams, Matthew A

“…Abstract The establishment of durable immunological memory remains a poorly understood aspect of lymphocyte biology and a limiting factor in vaccine…”
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The transcriptional coactivator OCA-B re-wires metabolism and promotes CD4 T cell memory by Tantin, Dean R, Williams, Matthew A, Hale, J Scott, Kim, Heejoo

“…Abstract OCA-B (Pou2af1/OBF-1/Bob.1) is a transcriptional coregulatory protein that is not expressed in naïve CD4+ T cells, but becomes stably induced…”
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Tet2-mediated programing balances T follicular helper cell and T helper 1 cell differentiation by Hale, J. Scott, Baessler, Andrew, Novis, Camille L, Shen, Zuolian, Perovanovic, Jelena, Wadsworth, Mark, Sircy, Linda M, Harrison-Chau, Malia, Varley, Katherine E, Tantin, Dean R

“…Abstract The differentiation of CD4+ T cell subsets in response to infection has been studied extensively, however the epigenetic programs that regulate these…”
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Oct1 and OCA-B in T cells are potent therapeutic targets for autoimmune diseases by Kim, Heejoo, Shakya, Arvind, Dickey, Laura, Stone, Colleen, Lane, Thomas, Williams, Matthew A, Tantin, Dean R

“…Abstract Oct1 and OCA-B function together in CD4 T cells to promote poised gene expression states in immunomodulatory target genes (e.g. Il2, Il21, Ifng, Icos…”
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Transcription coactivator OCA-B mediates interactions between target loci in T cells and is sufficient to promote CD4 memory in vivo by Tantin, Dean R, Zhao, Keiji, Williams, Matthew A, Hale, J Scott, Lai, Binbin, Ren, Gang, Kim, Heejoo

“…Abstract Stable epigenetic changes occurring during T cell activation are crucial for the generation of immunological memory. In CD4 T cells, OCA-B…”
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Genetic and pharmaceutical targeting of OCA-B/ Pou2af1 blocks T1D in mouse models by Kim, Heejoo, Shakya, Arvind, Perovanovic, Jelena, Ibarra, Andrea, Evavold, Brian, Chou, Danny H.-C., He, Xiao, Jensen, Peter E, Tantin, Dean R

“…Abstract Treatments for autoimmunity aim to inhibit autoreactivity while preserving normal immune function. The transcriptional coregulator OCA-B (gene symbol…”
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