Search Results - "Tansey, William P."

Ubiquitin and Proteasomes in Transcription by Geng, Fuqiang, Wenzel, Sabine, Tansey, William P

“…Regulation of gene transcription is vitally important for the maintenance of normal cellular homeostasis. Failure to correctly regulate gene expression, or to…”
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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC by Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.

“…MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind…”
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Inhibition of MYC by the SMARCB1 tumor suppressor by Weissmiller, April M., Wang, Jing, Lorey, Shelly L., Howard, Gregory C., Martinez, Ernest, Liu, Qi, Tansey, William P.

“…SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to…”
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Stable Histone Adduction by 4‑Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics by Galligan, James J, Rose, Kristie L, Beavers, William N, Hill, Salisha, Tallman, Keri A, Tansey, William P, Marnett, Lawrence J

“…Lipid electrophiles modify cellular targets, altering their function. Here, we describe histones as major targets for modification by 4-oxo-2-nonenal,…”
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The MYC-WDR5 Nexus and Cancer by Thomas, Lance R, Foshage, Audra M, Weissmiller, April M, Tansey, William P

“…The MYC oncogenes encode a family of transcription factors that feature prominently in cancer. MYC proteins are overexpressed or deregulated in a majority of…”
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How the ubiquitin-proteasome system controls transcription by Tansey, William P, Muratani, Masafumi

“…Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of…”
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Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin by Geng, Fuqiang, Tansey, William P

“…It has recently become clear that components of the proteasome are recruited to sites of gene transcription. Prevailing evidence suggests that the…”
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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1 by Popay, Tessa M, Wang, Jing, Adams, Clare M, Howard, Gregory Caleb, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Thomas, Lance R, Lorey, Shelly L, Machida, Yuichi J, Weissmiller, April M, Eischen, Christine M, Liu, Qi, Tansey, William P

“…The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer…”
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The proteasome: a utility tool for transcription? by Collins, Galen A, Tansey, William P

“…A growing body of evidence demonstrates that the components of the proteasome are involved directly and mechanistically in the regulation of gene…”
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Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus by Streeter, Sarah A, Williams, Alexandria G, Evans, James R, Wang, Jing, Guarnaccia, Alissa D, Florian, Andrea C, Al-Tobasei, Rafet, Liu, Qi, Tansey, William P, Weissmiller, April M

“…During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by…”
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Proteolytic Control of the Oncoprotein Transcription Factor Myc by Thomas, Lance R., Tansey, William P.

“…The c-Myc oncogene encodes a multifunctional transcription factor that directs the expression of genes required for cell growth and proliferation. Consistent…”
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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity by Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.

“…The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN…”
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Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers by Wolpaw, Adam J, Bayliss, Richard, Büchel, Gabriele, Dang, Chi V, Eilers, Martin, Gustafson, W Clay, Hansen, Gwenn H, Jura, Natalia, Knapp, Stefan, Lemmon, Mark A, Levens, David, Maris, John M, Marmorstein, Ronen, Metallo, Steven J, Park, Julie R, Penn, Linda Z, Rape, Michael, Roussel, Martine F, Shokat, Kevan M, Tansey, William P, Verba, Kliment A, Vos, Seychelle M, Weiss, William A, Wolf, Elmar, Mossé, Yaël P

“…Effective treatment of pediatric solid tumors has been hampered by the predominance of currently "undruggable" driver transcription factors. Improving outcomes…”
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WIN site inhibition disrupts a subset of WDR5 function by Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.

“…WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent…”
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Emerging Themes in Mechanisms of Tumorigenesis by SWI/SNF Subunit Mutation by Jones, Cheyenne A., Tansey, William P., Weissmiller, April M.

“…The SWI/SNF chromatin remodeling complex uses the energy of ATP hydrolysis to alter contacts between DNA and nucleosomes, allowing regions of the genome to…”
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Myc-mediated transcriptional repression by recruitment of histone deacetylase by Kurland, John F, Tansey, William P

“…Myc is a transcription factor that features prominently in cancer. The oncogenicity of Myc stems from its ability to regulate expression of genes required for…”
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Polyubiquitylation of histone H2B by Geng, Fuqiang, Tansey, William P

“…Covalent modification of histones by ubiquitylation is a prominent epigenetic mark that features in a variety of chromatin-based events such as histone…”
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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition by Howard, Gregory Caleb, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen, Liu, Qi, Tansey, William P

“…The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding…”
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Proteasomal ATPases Link Ubiquitylation of Histone H2B to Methylation of Histone H3 by Ezhkova, Elena, Tansey, William P.

“…In Saccharomyces cerevisiae, methylation of histone H3 at active genes is an epigenetic mark that distinguishes active from silent chromatin and functions as a…”
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Targeting what is not there to treat cancer by Tansey, William P.

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