Role of PAT proteins in lipid metabolism

Role of PAT proteins in lipid metabolism

One of the central reactions in bodily energy metabolism is lipolysis in adipocytes, the reaction that governs the release of stored fatty acids from the adipocyte triacylglycerol pool, which constitutes the major energy reserve in animals. These fatty acids are then transported by serum albumin to...

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Bibliographic Details
Published in:Biochimie Vol. 87; no. 1; pp. 45 - 49
Main Authors: Londos, C., Sztalryd, C., Tansey, J.T., Kimmel, A.R.
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 2005
Subjects:
3T3 Cells
Adipocytes - metabolism
Animals
Carrier Proteins
Cyclic AMP-Dependent Protein Kinases - metabolism
DNA-Binding Proteins - physiology
Humans
Intracellular Signaling Peptides and Proteins - physiology
Lipid Metabolism
Membrane Proteins - physiology
Mice
Perilipin-1
Perilipin-2
Perilipin-3
Phosphoproteins - genetics
Phosphoproteins - physiology
Pregnancy Proteins - physiology
Sterol Esterase - metabolism
Vesicular Transport Proteins
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Summary:One of the central reactions in bodily energy metabolism is lipolysis in adipocytes, the reaction that governs the release of stored fatty acids from the adipocyte triacylglycerol pool, which constitutes the major energy reserve in animals. These fatty acids are then transported by serum albumin to various tissues to supply their energy requirements. This reaction was previously thought to result from phosphorylation and activation of hormone-sensitive lipase by protein kinase A (PKA) but is now known to be governed by a translocation of the lipase from the cytosol to the surface of the intracellular lipid droplet that houses the reservoir of TAG. This droplet is coated with perilipin A, which is also phosphorylated by PKA in response to lipolytic stimuli, and phosphorylation of perilipin A is essential for HSL translocation and stimulated lipolysis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2004.12.010