Effective Control of Brain Metastases Irrespective of Distance from Isocenter in Single-isocenter Multitarget Stereotactic Radiosurgery

Effective Control of Brain Metastases Irrespective of Distance from Isocenter in Single-isocenter Multitarget Stereotactic Radiosurgery

Few previous studies have evaluated the effectiveness of single-isocenter multitarget (SIMT) stereotactic radiosurgery (SRS) in clinical practice. Gross tumor volumes of 113 metastases in 13 patients were measured by contrast-enhanced magnetic resonance imaging. Prescribed doses were set at 20-24 Gy...

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Bibliographic Details
Published in:Anticancer research Vol. 41; no. 5; pp. 2575 - 2581
Main Authors: Aoki, Ken, Nagatani, Yukihiro, Noma, Kazuo, Tsugawa, Takuya, Kono, Naoaki, Kida, Yukako, Harada, Naoki, Tanoue, Yoshihide, Watanabe, Yoshiyuki
Format: Journal Article
Language:English
Published: Greece International Institute of Anticancer Research 01-05-2021
Subjects:
Brain
Brain cancer
Magnetic resonance imaging
Metastases
Metastasis
Neuroimaging
Radiology
Radiosurgery
Shrinkage
Surgery
Tumors
lung cancer
dynamic conformal arc
contrast-enhanced magnetic resonance imaging
Single-isocenter
brain metastasis
tumor quantification
stereotactic radiosurgery
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Summary:Few previous studies have evaluated the effectiveness of single-isocenter multitarget (SIMT) stereotactic radiosurgery (SRS) in clinical practice. Gross tumor volumes of 113 metastases in 13 patients were measured by contrast-enhanced magnetic resonance imaging. Prescribed doses were set at 20-24 Gy. Based on tumor reduction rates (TRRs) measured before and after SIMT SRS, tumor shrinkage effect was categorized into four grades; almost disappeared: TRR=1, decreased: 0.3≤TRR<1, stable: -0.2<TRR<0.3 and increased: TRR≤-0.2. Tumor shrinkage effects were compared among 3 groups; near group with a distance of <3.2 cm, middle group with a distance of ≥3.2 cm and <6.4 cm, and far group with a distance of ≥6.4 cm, categorized by distance from the isocenter. Median survival time was 17 months, with 63.7%, 11.5% and 12.4% of metastases corresponded to almost disappeared, decreased and stable, respectively. No significant difference was found in the distribution for TRRs among 3 groups. Good local control of multiple brain metastases was demonstrated by SIMT SRS, irrespective of distance from the isocenter.
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ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15036