Search Results - "Tanny, Jason C"

A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II by Parua, Pabitra K., Booth, Gregory T., Sansó, Miriam, Benjamin, Bradley, Tanny, Jason C., Lis, John T., Fisher, Robert P.

“…The end of the RNA polymerase II (Pol II) transcription cycle is strictly regulated to prevent interference between neighbouring genes and to safeguard…”
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Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery by Martin, Ryan D, Hébert, Terence E, Tanny, Jason C

“…Inhibitors targeting the general RNA polymerase II (RNAPII) transcription machinery are candidate therapeutics in cancer and other complex diseases. Here, we…”
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Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms by MacKinnon, Sarah, Pagé, Viviane, Chen, Jennifer J, Shariat-Panahi, Ali, Martin, Ryan D, Hébert, Terence E, Tanny, Jason C

“…Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome…”
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Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors by Martin, Ryan D., Sun, Yalin, MacKinnon, Sarah, Cuccia, Luca, Pagé, Viviane, Hébert, Terence E., Tanny, Jason C.

“…Pathological cardiac hypertrophy is driven by neurohormonal activation of specific G protein-coupled receptors (GPCRs) in cardiomyocytes and is accompanied by…”
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A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in rat striatal neurons by Jones-Tabah, Jace, Martin, Ryan D., Chen, Jennifer J., Tanny, Jason C., Clarke, Paul B.S., Hébert, Terence E.

“…The activity of striatal medium-spiny projection neurons is regulated by D1 and D2 dopamine receptors. The D1 receptor (D1R) is a Gαs/olf-coupled GPCR which…”
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Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes by Bourque, Kyla, Jones-Tabah, Jace, Pétrin, Darlaine, Martin, Ryan D., Tanny, Jason C., Hébert, Terence E.

“…The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell…”
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Decoding histone ubiquitylation by Chen, Jennifer J., Stermer, Dylan, Tanny, Jason C.

“…Histone ubiquitylation is a critical part of both active and repressed transcriptional states, and lies at the heart of DNA damage repair signaling. The…”
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Chromatin modification by the RNA Polymerase II elongation complex by Tanny, Jason C.

“…Transcription elongation by RNA polymerase II (RNAP II) involves the coordinated action of numerous regulatory factors. Among these are chromatin-modifying…”
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The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast by Mbogning, Jean, Nagy, Stephen, Pagé, Viviane, Schwer, Beate, Shuman, Stewart, Fisher, Robert P, Tanny, Jason C

“…Cyclin-dependent kinase 9 (Cdk9) promotes elongation by RNA polymerase II (RNAPII), mRNA processing, and co-transcriptional histone modification. Cdk9…”
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Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs by Taverna, Sean D., Ilin, Serge, Rogers, Richard S., Tanny, Jason C., Lavender, Heather, Li, Haitao, Baker, Lindsey, Boyle, John, Blair, Lauren P., Chait, Brian T., Patel, Dinshaw J., Aitchison, John D., Tackett, Alan J., Allis, C. David

“…Posttranslational histone modifications participate in modulating the structure and function of chromatin. Promoters of transcribed genes are enriched with K4…”
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Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation by Tanny, Jason C, Erdjument-Bromage, Hediye, Tempst, Paul, Allis, C David

“…Transcription by RNA polymerase II (polII) is accompanied by dramatic changes in chromatin structure. Numerous enzymatic activities contribute to these…”
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Assembly of the SIR Complex and Its Regulation by O-Acetyl-ADP-Ribose, a Product of NAD-Dependent Histone Deacetylation by Liou, Gunn-Guang, Tanny, Jason C., Kruger, Ryan G., Walz, Thomas, Moazed, Danesh

“…Assembly of silent chromatin domains in budding yeast involves the deacetylation of histone tails by Sir2 and the association of the Sir3 and Sir4 proteins…”
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Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification by Mbogning, Jean, Pagé, Viviane, Burston, Jillian, Schwenger, Emily, Fisher, Robert P, Schwer, Beate, Shuman, Stewart, Tanny, Jason C

“…Transcription by RNA polymerase II (RNAPII) is accompanied by a conserved pattern of histone modifications that plays important roles in regulating gene…”
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A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast by Sansó, Miriam, Lee, Karen M, Viladevall, Laia, Jacques, Pierre-Étienne, Pagé, Viviane, Nagy, Stephen, Racine, Ariane, St Amour, Courtney V, Zhang, Chao, Shokat, Kevan M, Schwer, Beate, Robert, François, Fisher, Robert P, Tanny, Jason C

“…Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have…”
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Coupling of Histone Deacetylation to NAD Breakdown by the Yeast Silencing Protein Sir2: Evidence for Acetyl Transfer from Substrate to an NAD Breakdown Product by Tanny, Jason C., Moazed, Danesh

“…The Saccharomyces cerevisiae silencing protein Sir2 is the founding member of a universally conserved family of proteins that have been shown to possess…”
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Histone H2B Ubiquitylation Promotes Activity of the Intact Set1 Histone Methyltransferase Complex in Fission Yeast by Racine, Ariane, Pagé, Viviane, Nagy, Stephen, Grabowski, David, Tanny, Jason C.

“…The methylation of histone H3 at lysine 4 (H3K4me) is critical for the formation of transcriptionally active chromatin in eukaryotes. In yeast, Drosophila, and…”
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Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation by Hoppe, Georg J., Tanny, Jason C., Rudner, Adam D., Gerber, Scott A., Danaie, Sherwin, Gygi, Steven P., Moazed, Danesh

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Components of the ESCRT Pathway, DFG16, and YGR122w Are Required for Rim101 To Act as a Corepressor with Nrg1 at the Negative Regulatory Element of the DIT1 Gene of Saccharomyces cerevisiae by Rothfels, Karen, Tanny, Jason C., Molnar, Enikö, Friesen, Helena, Commisso, Cosimo, Segall, Jacqueline

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Budding Yeast Silencing Complexes and Regulation of Sir2 Activity by Protein-Protein Interactions by Tanny, Jason C., Kirkpatrick, Donald S., Gerber, Scott A., Gygi, Steven P., Moazed, Danesh

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New connections between ubiquitylation and methylation in the co-transcriptional histone modification network by Pinto, Daniel, Pagé, Vivane, Fisher, Robert P., Tanny, Jason C.

“…Co-transcriptional histone modifications are a ubiquitous feature of RNA polymerase II (RNAPII) transcription, with profound but incompletely understood…”
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