Search Results - "Tanner, Kirk G."

Silent Information Regulator 2 Family of NAD-Dependent Histone/Protein Deacetylases Generates a Unique Product, 1-O-Acetyl-ADP-Ribose by Tanner, K G, Landry, J, Sternglanz, R, Denu, J M

“…Conflicting reports have suggested that the silent information regulator 2 (SIR2) protein family employs NAD+to ADP-ribosylate histones [Tanny, J. C., Dowd, G…”
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Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide:  Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation by Denu, John M, Tanner, Kirk G

“…Protein tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphotyrosine from specific signal-transducing proteins. Although regulatory mechanisms for…”
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Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation by Cheung, Peter, Tanner, Kirk G, Cheung, Wang L, Sassone-Corsi, Paolo, Denu, John M, Allis, C.David

“…Histone acetylation and phosphorylation have separately been suggested to affect chromatin structure and gene expression. Here we report that these two…”
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Structural Basis for the Recognition of a Bisphosphorylated MAP Kinase Peptide by Human VHR Protein Phosphatase by Schumacher, Maria A, Todd, Jacob L, Rice, Adrian E, Tanner, Kirk G, Denu, John M

“…Human VHR (vaccinia H1 related phosphatase) is a member of the dual-specificity phosphatases (DSPs) that often act on bisphosphorylated protein substrates…”
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The Acetyltransferase Activity of CBP Is Required for wingless Activation and H4 Acetylation in Drosophila melanogaster by Ludlam, William H., Taylor, Matthew H., Tanner, Kirk G., Denu, John M., Goodman, Richard H., Smolik, Sarah M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator by Tanner, K G, Trievel, R C, Kuo, M H, Howard, R M, Berger, S L, Allis, C D, Marmorstein, R, Denu, J M

“…Within chromatin, reversible acetylation of core histones is critical for transcriptional activation of eukaryotic target genes. The recent identification of…”
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Kinetic Mechanism of the Histone Acetyltransferase GCN5 from Yeast by Tanner, Kirk G., Langer, Michael R., Kim, Youngjoo, Denu, John M.

“…The transcriptional coactivator GCN5 from yeast (yGCN5) is a histone acetyltransferase that is essential for activation of target genes. GCN5 is a member of a…”
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Dimerization of the Extracellular Domain of the Receptor for Epidermal Growth Factor Containing the Membrane-spanning Segment in Response to Treatment with Epidermal Growth Factor by Tanner, K G, Kyte, J

“…A recombinant fragment of the human receptor for epidermal growth factor containing both its extracellular domain and its membrane-spanning segment, when…”
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Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivation by Denu, John M, Tanner, Kirk G

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Kinetic Mechanism of Human Histone Acetyltransferase P/CAF by Tanner, Kirk G, Langer, Michael R, Denu, John M

“…Human transcriptional coactivator P/CAF (p300/CBP-associating factor) is a histone acetyltransferase (HAT) and is a member of the GNAT (GCN5 related…”
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Mutational Analysis of Conserved Residues in the GCN5 Family of Histone Acetyltransferases by Langer, M R, Tanner, K G, Denu, J M

“…GCN5 is a critical transcriptional co-activator and is the defining member of a large superfamily of N -acetyltransferases. GCN5 catalyzes the transfer of an…”
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Kinetic Mechanism of Human Histone Acetyltransferase P/CAF by Tanner, Kirk G, Langer, Michael R, Denu, John M

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Persistence of Dimerization and Enzymatic Activity of Epidermal Growth Factor Receptor in the Absence of Epidermal Growth Factor by Tanner, Kirk G

“…Dimerized and enzymatically active epidermal growth factor receptor, in the presence of saturating epidermal growth factor (EGF), was passed over a column…”
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Extracellular Regulated Kinases (ERK) 1 and ERK2 Are Authentic Substrates for the Dual-specificity Protein-tyrosine Phosphatase VHR by Todd, Jacob L., Tanner, Kirk G., Denu, John M.

“…The mammalian dual-specificity protein-tyrosine phosphatase VHR (forVH1-related) has been identified as a novel regulator of extracellular regulated kinases…”
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Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway by Todd, J L, Tanner, K G, Denu, J M

“…The mammalian dual-specificity protein-tyrosine phosphatase VHR (for VH1-related) has been identified as a novel regulator of extracellular regulated kinases…”
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A Continuous, Nonradioactive Assay for Histone Acetyltransferases by Kim, Youngjoo, Tanner, Kirk G., Denu, John M.

“…Histone acetyltransferases (HATs) catalyze the acetyl-group transfer from acetyl-CoA to the ε-amino group of specific lysine residues within core histone…”
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A model for the dimerization of epidermal growth factor receptor by Tanner, Kirk G

“…Dimerized and enzymatically active epidermal growth factor receptor, in the presence of saturating epidermal growth factor (EGF), was passed over a column…”
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