Search Results - "Tanner, Huw"

Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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A Versatile Synthesis of Unsymmetrical 3,3′-Bioxindoles: Stereoselective Mukaiyama Aldol Reactions of 2-Siloxyindoles with Isatins by Ellis, J. Michael, Overman, Larry E, Tanner, Huw R, Wang, Jocelyn

“…A new synthesis of 3,3′-bioxindoles is reported that is well suited for the preparation of unsymmetrical structures. In the key step,…”
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Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry by Ball, Matthew, Gaunt, Matthew J., Hook, David F., Jessiman, Alan S., Kawahara, Shigeru, Orsini, Paolo, Scolaro, Alessandra, Talbot, Adam C., Tanner, Huw R., Yamanoi, Shigeo, Ley, Steven V.

“…The challenging structure and potent growth inhibition properties against a variety of human cancer cell lines make Spongistatin 1 (1) an exciting target for…”
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Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1 by Gaunt, Matthew J, Jessiman, Alan S, Orsini, Paolo, Tanner, Huw R, Hook, David F, Ley, Steven V

“…The synthesis of the C-1−C-28 ABCD fragment of spongistatin is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment to an…”
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A Practical and Efficient Synthesis of the C-16−C-28 Spiroketal Fragment (CD) of the Spongistatins by Gaunt, Matthew J, Hook, David F, Tanner, Huw R, Ley, Steven V

“…A practical and efficient route to the CD spiroketal (C-16−C-28) of the spongistatins is reported. Two stereocenters are introduced from chiral building blocks…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation by Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Ramurthy, Savithri, Cooke, Vesselina, Griner, Lesley, Nishiguchi, Gisele, Rico, Alice, Taft, Ben, Burger, Matthew, Tanner, Huw, Polyakov, Valery, Appleton, Brent, Tellew, John, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Stuart, Darrin

“…The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at multiple…”
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Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation by Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Ramurthy, Savithri, Cooke, Vesselina, Griner, Lesley, Nishiguchi, Gisele, Rico, Alice, Taft, Ben, Burger, Matthew, Tanner, Huw, Polyakov, Valery, Appleton, Brent, Tellew, John, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Stuart, Darrin

“…Abstract The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at…”
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Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry by Ball, Matthew, Gaunt, Matthew J., Hook, David F., Jessiman, Alan S., Kawahara, Shigeru, Orsini, Paolo, Scolaro, Alessandra, Talbot, Adam C., Tanner, Huw R., Yamanoi, Shigeo, Ley, Steven V.

“…Die komplizierte Struktur und die starke wachstumshemmende Wirkung gegen viele humane Krebszelllinien haben Spongistatin 1 (1) zu einer interessanten…”
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Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo‐Symmetry by Ball, Matthew, Gaunt, Matthew J., Hook, David F., Jessiman, Alan S., Kawahara, Shigeru, Orsini, Paolo, Scolaro, Alessandra, Talbot, Adam C., Tanner, Huw R., Yamanoi, Shigeo, Ley, Steven V.

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