Search Results - "Tannahill, Gillian M."

TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation by Worboys, Jonathan D., Vowell, Katherine N., Hare, Roseanna K., Ambrose, Ashley R., Bertuzzi, Margherita, Conner, Michael A., Patel, Florence P., Zammit, William H., Gali-Moya, Judit, Hazime, Khodor S., Jones, Katherine L., Rey, Camille, Jonjic, Stipan, Rovis, Tihana Lenac, Tannahill, Gillian M., Cruz De Matos, Gabriela Dos Santos, Waight, Jeremy D., Davis, Daniel M.

“…TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through…”
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Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages by Diaz-Del-Olmo, Ines, Worboys, Jonathan, Martin-Sanchez, Fatima, Gritsenko, Anna, Ambrose, Ashley R, Tannahill, Gillian M, Nichols, Eva-Maria, Lopez-Castejon, Gloria, Davis, Daniel M

“…Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its…”
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Heterogeneity in extracellular vesicle secretion by single human macrophages revealed by super‐resolution microscopy by Dechantsreiter, Susanne, Ambrose, Ashley R., Worboys, Jonathan D., Lim, Joey M. E., Liu, Sylvia, Shah, Rajesh, Montero, M. Angeles, Quinn, Anne Marie, Hussell, Tracy, Tannahill, Gillian M., Davis, Daniel M.

“…The diverse origins, nanometre‐scale and invasive isolation procedures associated with extracellular vesicles (EVs) mean they are usually studied in bulk and…”
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Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry by Yang, Jennie H M, Khatri, Leena, Mickunas, Marius, Williams, Evangelia, Tatovic, Danijela, Alhadj Ali, Mohammad, Young, Philippa, Moyle, Penelope, Sahni, Vishal, Wang, Ryan, Kaur, Rejbinder, Tannahill, Gillian M, Beaton, Andrew R, Gerlag, Danielle M, Savage, Caroline O S, Napolitano Rosen, Antonella, Waldron-Lynch, Frank, Dayan, Colin M, Tree, Timothy I M

“…Ultrasound guided sampling of human lymph node (LN) combined with advanced flow cytometry allows phenotypic analysis of multiple immune cell subsets. These may…”
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Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α by Adamik, Juraj, Wang, Kent Z Q, Unlu, Sebnem, Su, An-Jey A, Tannahill, Gillian M, Galson, Deborah L, O'Neill, Luke A, Auron, Philip E

“…Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the…”
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SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation by Tannahill, Gillian M., Elliott, Joanne, Barry, Anna C., Hibbert, Linda, Cacalano, Nicolas A., Johnston, James A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages by Kelly, Beth, Tannahill, Gillian M., Murphy, Michael P., O'Neill, Luke A.J.

“…Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-form of the inflammatory cytokine IL-1β in response to LPS in…”
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Identifying cell-enriched miRNAs in kidney injury and repair by Connor, Katie L, Teenan, Oliver, Cairns, Carolynn, Banwell, Victoria, Thomas, Rachel Ab, Rodor, Julie, Finnie, Sarah, Pius, Riinu, Tannahill, Gillian M, Sahni, Vishal, Savage, Caroline Os, Hughes, Jeremy, Harrison, Ewen M, Henderson, Robert B, Marson, Lorna P, Conway, Bryan R, Wigmore, Stephen J, Denby, Laura

“…Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney…”
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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism by Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

“…Mixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell…”
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes by Mullooly, Niamh, Mills, Kingston H G, O'Neill, Luke A J, Kahn, Steven E, Mok, K Hun, Chen, Zhe, Tannahill, Gillian M, Dunne, Aisling, Becker, Christine, Sharp, Fiona A, Lavelle, Ed C, Yoshihara, Eiji, Mielke, Lisa A, Franchi, Luigi, Yodoi, Junji, Subramanian, Shoba L, Harris, James, Coll, Rebecca C, Newsholme, Philip, Masters, Seth L, Hull, Rebecca L, Nuñez, Gabriel

“…Pancreatic islets in type 2 diabetes show characteristic deposition of the amyloid polypeptide IAPP. O'Neill and colleagues show that IAPP induces IL-1β…”
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A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction by Hildebrand, Joanne M., Kauppi, Maria, Majewski, Ian J., Liu, Zikou, Cox, Allison J., Miyake, Sanae, Petrie, Emma J., Silk, Michael A., Li, Zhixiu, Tanzer, Maria C., Brumatti, Gabriela, Young, Samuel N., Hall, Cathrine, Garnish, Sarah E., Corbin, Jason, Stutz, Michael D., Di Rago, Ladina, Gangatirkar, Pradnya, Josefsson, Emma C., Rigbye, Kristin, Anderton, Holly, Rickard, James A., Tripaydonis, Anne, Sheridan, Julie, Scerri, Thomas S., Jackson, Victoria E., Czabotar, Peter E., Zhang, Jian-Guo, Varghese, Leila, Allison, Cody C., Pellegrini, Marc, Tannahill, Gillian M., Hatchell, Esme C., Willson, Tracy A., Stockwell, Dina, de Graaf, Carolyn A., Collinge, Janelle, Hilton, Adrienne, Silke, Natasha, Spall, Sukhdeep K., Chau, Diep, Athanasopoulos, Vicki, Metcalf, Donald, Laxer, Ronald M., Bassuk, Alexander G., Darbro, Benjamin W., Fiatarone Singh, Maria A., Vlahovich, Nicole, Hughes, David, Kozlovskaia, Maria, Ascher, David B., Warnatz, Klaus, Venhoff, Nils, Thiel, Jens, Biben, Christine, Blum, Stefan, Reveille, John, Hildebrand, Michael S., Vinuesa, Carola G., McCombe, Pamela, Brown, Matthew A., Kile, Benjamin T., McLean, Catriona, Bahlo, Melanie, Masters, Seth L., Nakano, Hiroyasu, Ferguson, Polly J., Murphy, James M., Alexander, Warren S., Silke, John

“…MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl…”
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Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages by Ambrose, Ashley R., Dechantsreiter, Susanne, Shah, Rajesh, Montero, M. Angeles, Quinn, Anne Marie, Hessel, Edith M., Beinke, Soren, Tannahill, Gillian M., Davis, Daniel M.

“…Observing the cell surface and underlying cytoskeleton at nanoscale resolution using super-resolution microscopy has enabled many insights into cell signaling…”
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The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3 by Tannahill, Gillian M., O’Neill, Luke A.J.

“…While it has long been suspected that inflammation participates in the pathogenesis of metabolic disorders such as the insulin resistance that occurs in type 2…”
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Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27 by Brender, Christine, Tannahill, Gillian M., Jenkins, Brendan J., Fletcher, Joel, Columbus, Ruth, Saris, Christiaan J.M., Ernst, Matthias, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S., Starr, Robyn

“…Suppressor of cytokine signaling (SOCS) proteins regulate the intensity and duration of cytokine responses. SOCS3 is expressed in peripheral T cells, and…”
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The P‐TEFb‐dependent Gene Coding for IL‐1β is More Sensitive to Cellular Metabolism than that of the BRD4‐dependent TNFα‐coding Gene by Adamik, Juraj, Tannahill, Gillian M., Su, An‐Jey A, O'Neill, Luke A, Galson, Deborah L, Auron, Philip E.

“…Abstract only The induction of the immediate‐early genes coding for Interleukin 1β (IL‐1β) and Tumor Necrosis Factor α (TNFα) is dependent upon Toll‐Like…”
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Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1[beta] and Tumor Necrosis Factor [alpha] by Adamik, Juraj, Wang, Kent Z. Q, Unlu, Sebnem, Su, An-Jey A, Tannahill, Gillian M, Galson, Deborah L, O'Neill, Luke A, Auron, Philip E

“…Interleukin-1[beta] and Tumor Necrosis Factor [alpha] play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic…”
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2: The P-TEFb-dependent gene coding for IL-1β is more sensitive to cellular metabolism than that of the BRD4-dependent TNFα-coding gene by Adamik, Juraj, Tannahill, Gillian M., Su, An-Jey A., O’Neill, Luke A., Galson, Deborah L., Auron, Philip E.

“…The induction of the immediate-early genes coding for Interleukin 1β (IL1B) and Tumor Necrosis Factor α (TNF) is dependent upon Toll-Like receptor 4 (TLR4)…”
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2 by Adamik, Juraj, Tannahill, Gillian M., Su, An-Jey A., O’Neill, Luke A., Galson, Deborah L., Auron, Philip E.

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes by Masters, Seth L, Dunne, Aisling, Subramanian, Shoba L, Hull, Rebecca L, Tannahill, Gillian M, Sharp, Fiona A, Becker, Christine, Franchi, Luigi, Yoshihara, Eiji, Chen, Zhe, Mullooly, Niamh, Mielke, Lisa A, Harris, James, Coll, Rebecca C, Mills, Kingston H G, Mok, K Hun, Newsholme, Philip, Nunez, Gabriel, Yodoi, Junji, Kahn, Steven E, Lavelle, Ed C, O'Neill, Luke A J

“…Interleukin 1b (IL-1b) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein…”
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1[beta] in type 2 diabetes by Masters, Seth L, Dunne, Aisling, Subramanian, Shoba L, Hull, Rebecca L, Tannahill, Gillian M, Sharp, Fiona A, Becker, Christine, Franchi, Luigi, Yoshihara, Eiji, Chen, Zhe, Mullooly, Niamh, Mielke, Lisa A, Harris, James, Coll, Rebecca C, Mills, Kingston H G, Mok, K Hun, Newsholme, Philip, Nuñez, Gabriel, Yodoi, Junji, Kahn, Steven E, Lavelle, Ed C, O'neill, Luke A J

“…Interleukin 1[beta] (IL-1[beta]) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a…”
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