Search Results - "Tannahill, C L"

Liposome-mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre-existing inflammation by NORMAN, J, DENHAM, W, DENHAM, D, YANG, J, CARTER, G, ABOUHAMZE, A, TANNAHILL, C. L, MACKAY, S. L. D, MOLDAWER, L. L

“…Cationic liposome and plasmid-mediated gene transfer has emerged as a novel technique for the targeted delivery of protein-based therapies in acute…”
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Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure by MCAULIFFE, P. F, MURDAY, M. E, EFRON, P. A, SCUMPIA, P. O, UNGARO, R, ABOUHAMZE, Amer, TANNAHILL, C. L, HUTCHINS, B, LAFACE, D, MOLDAWER, L. L

“…Targeted expression of interleukin-10 (IL-10) has been proposed as a means to suppress acute and chronic inflammation. We explored the capacity of targeted…”
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Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis by Minter, Rebecca M, Ferry, Maria A, Murday, Michelle E, Tannahill, Cynthia L, Bahjat, Frances R, Oberholzer, Caroline, Oberholzer, Andreas, LaFace, Drake, Hutchins, Beth, Wen, Shufen, Shinoda, Jeremy, Copeland, Edward M., III, Moldawer, Lyle L

“…Adenovirus (Ad) gene therapy has been proposed as a drug-delivery system for the targeted administration of protein-based therapies, including growth factors…”
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Induction and immunolocalization of manganese superoxide dismutase in acute acetic acid-induced colitis in the rat by Tannahill, C L, Stevenot, S A, Campbell-Thompson, M, Nick, H S, Valentine, J F

“…Oxygen radicals and reactive oxygen species play an important role in inflammatory episodes in the bowel. Nonetheless, little is known about the regulation of…”
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Targeted Adenovirus-Induced Expression of IL-10 Decreases Thymic Apoptosis and Improves Survival in Murine Sepsis by Oberholzer, Caroline, Oberholzer, Andreas, Bahjat, Frances R., Minter, Rebecca M., Tannahill, Cynthia L., Abouhamze, Amer, LaFace, Drake, Hutchins, Beth, Clare-Salzler, Michael J., Moldawer, Lyle L.

“…Sepsis remains a significant clinical conundrum, and recent clinical trials with anticytokine therapies have produced disappointing results. Animal studies…”
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Regulation of superoxide dismutase in primary cultures of rat colonic smooth muscle cells by Tannahill, C L, Stevenot, S A, Eaker, E Y, Sallustio, J E, Nick, H S, Valentine, J F

“…We have observed a rapid induction of manganese superoxide dismutase (MnSOD) in epithelial, neuronal, and smooth muscle cells (SMC) after acetic acid-induced…”
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Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis by Ksontini, R, Colagiovanni, D B, Josephs, M D, Edwards, 3rd, C K, Tannahill, C L, Solorzano, C C, Norman, J, Denham, W, Clare-Salzler, M, MacKay, S L, Moldawer, L L

“…Apoptosis is a physiologic process that serves to eliminate cells during development or in response to immunologic regulation. In acute inflammation, however,…”
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Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand by Josephs, M D, Bahjat, F R, Fukuzuka, K, Ksontini, R, Solorzano, C C, Edwards, 3rd, C K, Tannahill, C L, MacKay, S L, Copeland, 3rd, E M, Moldawer, L L

“…Tumor necrosis factor (TNF)-alpha and Fas ligand (FasL) are trimeric proteins that induce apoptosis through similar caspase-dependent pathways. Hepatocytes are…”
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Enhanced Collagen Accumulation Following Direct Transfection of the Inducible Nitric Oxide Synthase Gene in Cutaneous Wounds by Thornton, Frank J., Schäffer, Michael R., Witte, Maria B., Moldawer, Lyle L., MacKay, Sally L.D., Abouhamze, Amer, Tannahill, Cynthia L., Barbul, Adrian

“…Inducible nitric oxide synthase (iNOS) is expressed during cutaneous wound repair. Mounting evidence suggests that wound nitric oxide (NO) augments collagen…”
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TNF-alpha receptor signaling and IL-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung by Minter, R M, Rectenwald, J E, Fukuzuka, K, Tannahill, C L, La Face, D, Tsai, V, Ahmed, I, Hutchins, E, Moyer, R, Copeland, 3rd, E M, Moldawer, L L

“…Recombinant adenovirus-mediated gene therapy has demonstrated great promise for the delivery of genes to the pulmonary epithelium. However, dose-dependent…”
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Discordant tumor necrosis factor-α superfamily gene expression in bacterial peritonitis and endotoxemic shock by Tannahill, Cynthia L., Fukuzuka, Kunitaro, Marum, Tiffany, Abouhamze, Zaher, MacKay, Sally L.D., Copeland, Edward M., Moldawer, Lyle L.

“…Background: Tumor necrosis factor-α (TNF-α) is a member of a large family of predominantly homotrimeric type II membrane-associated proteins with both…”
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Colitis and interleukin 1β up-regulate inducible nitric oxide synthase and superoxide dismutase in rat myenteric neurons by VALENTINE, J. F, TANAHILL, C. L, STEVENOT, S. A, SALLUSTIO, J. E, NICK, H. S, EAKER, E. Y

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Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype by MacKay, S L, Auffenberg, T, Tannahill, C L, Ksontini, R, Josephs, M D, Nowak, M, Moldawer, L L, Copeland, 3rd, E M

“…To determine if transfection of SW48 colon cancer cells with the type II transforming growth factor-beta (TGF-beta) receptor restores growth inhibition and…”
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Colitis and interleukin 1beta up-regulate inducible nitric oxide synthase and superoxide dismutase in rat myenteric neurons by Valentine, JF, Tannahill, CL, Stevenot, SA, Sallustio, JE, Nick, HS, Eaker, EY

“…BACKGROUND & AIMS: Manganese superoxide dismutase (MnSOD) is rapidly induced in myenteric plexus neurons (MPNs) in acute colitis and may protect cells from…”
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Whole blood and leukocyte RNA isolation for gene expression analyses by Feezor, Robert J, Baker, Henry V, Mindrinos, Michael, Hayden, Doug, Tannahill, Cynthia L, Brownstein, Bernard H, Fay, Adrian, MacMillan, Sandra, Laramie, Jason, Xiao, Wenzhong, Moldawer, Lyle L, Cobb, J. Perren, Laudanski, Krzysztof, Miller-Graziano, Carol L, Maier, Ronald V, Schoenfeld, David, Davis, Ronald W, Tompkins, Ronald G, Inflammation and Host Response to Injury, Large-Scale Collaborative Research Program

“…1 Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 2 Department of Molecular Genetics and Microbiology, University of…”
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Microfluidic Isolation of Leukocytes from Whole Blood for Phenotype and Gene Expression Analysis by Sethu, Palaniappan, Moldawer, Lyle L, Mindrinos, Michael N, Scumpia, Philip O, Tannahill, Cynthia L, Wilhelmy, Julie, Efron, Philip A, Brownstein, Bernard H, Tompkins, Ronald G, Toner, Mehmet

“…Technologies that enable the isolation of cell subtypes from small samples of complex populations will greatly facilitate the implementation of proteomics and…”
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COMMON AND DISTINCT PATTERNS OF PULMONARY GENE EXPRESSION IN TWO INFLAMMATION MODELS: 199 by Minnich, D J, Feezor, R J, Efron, P A, Tannahill, C L, Baker, H V, Cance, W G, Moldawer, L L

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The relationship between tumour NF-kB expression, hormone status, and clinicopathological factors in primary invasive breast cancer by Tannahill, CL, Obondo, C, Al-Murri, AM, Doughty, JD, Lannigan, A, Wilson, CR, McMillan, DC, Edwards, J

“…Abstract #4038 Breast cancer is one of the most common and lethal malignancies in the UK. Conventionally, prognosis is based on hormone status, tumour size,…”
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RNA ISOLATION METHODS AFFECT THE MEASURE-MENT OF HUMAN LEUKOCYTE GENE EXPRESSION RESULTING FROM SEB STIMULATION: 195 by Feezor, R J, Baker, H V, Mindrinos, M, Tannahill, C L, Brownstein, B, Fay, A, MacMillan, S, Laramie, J, Hayden, D, Schoenfeld, D, Xiao, W, Moldawer, L L, Cobb, J P, Davis, R, Tompkins, R

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Characterization in vitro and in vivo of hammerhead ribozymes directed against murine tumor necrosis factoralpha by MacKay, S L, Tannahill, C L, Auffenberg, T, Ksontini, R, Copeland, 3rd, E M, Moldawer, L L

“…A hammerhead ribozyme directed against murine TNFalpha (mTNFalpha) mRNA has been constructed. In vitro studies showed that this ribozyme was released from the…”
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