Search Results - "Tanio, Masami"
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First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency
Published in Heliyon (01-11-2022)“…Familial lecithin: cholesterol acyltransferase (LCAT) deficiency (FLD) is a severe inherited disease without effective treatment. Patients with FLD develop…”
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Ceiling culture-derived proliferative adipocytes retain high adipogenic potential suitable for use as a vehicle for gene transduction therapy
Published in American Journal of Physiology: Cell Physiology (01-07-2011)“…Adipose tissue is expected to provide a source of proliferative cells for regenerative medicine and cell-transplantation therapies using gene transfer…”
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Fibrin glue is a candidate scaffold for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro
Published in Experimental cell research (2012)“…Adipose tissue is expected to provide a source of cells for protein replacement therapies via auto-transplantation. However, the conditioning of the…”
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Disturbed apolipoprotein A-I-containing lipoproteins in fish-eye disease are improved by the lecithin:cholesterol acyltransferase produced by gene-transduced adipocytes in vitro
Published in Molecular genetics and metabolism (01-02-2011)“…We report the in vitro efficacy of recombinant LCAT produced by lcat gene-transduced proliferative adipocytes (ccdPA/ lcat), which has been developed for…”
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Fibrin glue increases the cell survival and the transduced gene product secretion of the ceiling culture-derived adipocytes transplanted in mice
Published in Experimental & molecular medicine (2011)“…The development of clinically applicable scaffolds is important for the application of cell transplantation in various human diseases. The aims of this study…”
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Fibrin glue increases the cell survival and the transduced gene product secretion of the ceiling culture-derived adipocytes transplanted in mice
Published in Experimental & molecular medicine (2011)“…The development of clinically applicable scaffolds is important for the application of cell transplantation in various human diseases. The aims of this study…”
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Ceiling Culture-Derived Proliferative Adipocytes are A Possible Delivery Vehicle for Enzyme Replacement Therapy in Lecithin: Cholesterol Acyltransferase Deficiency
Published in The open gene therapy journal (01-01-2011)“…Human proliferative adipocytes propagated via ceiling culture technique from subcutaneous fat tissue (designated as ccdPA) were herein evaluated for their…”
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