Search Results - "Tanihara, Hidenobu"

Rho-associated kinase inhibitors: A novel glaucoma therapy by Inoue, Toshihiro, Tanihara, Hidenobu

“…The rho-associated kinase (ROCK) signaling pathway is activated via secreted bioactive molecules or via integrin activation after extracellular matrix binding…”
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Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma by Honjo, Megumi, Tanihara, Hidenobu

“…Rho-associated protein kinase (ROCK), a ubiquitously expressed signaling messenger and downstream effector of Rho, is activated by several bioactive factors in…”
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Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115 by Tanihara, Hidenobu, Inoue, Toshihiro, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Abe, Haruki, Araie, Makoto

“…We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the…”
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Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm’s canal endothelial cells by Kaneko, Yoshio, Ohta, Masayuki, Inoue, Toshihiro, Mizuno, Ken, Isobe, Tomoyuki, Tanabe, Sohei, Tanihara, Hidenobu

“…Ripasudil hydrochloride hydrate (K-115), a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, was the first ophthalmic solution…”
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Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension by Tanihara, Hidenobu, Inoue, Toshihiro, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Abe, Haruki, Araie, Makoto

“…Purpose To identify the optimal dose of a novel Rho kinase inhibitor, K-115, by assessing dose dependency of the intraocular pressure (IOP)-lowering effects…”
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Factors Influencing Aqueous Proinflammatory Cytokines and Growth Factors in Uveitic Glaucoma by Ohira, Saori, Inoue, Toshihiro, Iwao, Keiichiro, Takahashi, Eri, Tanihara, Hidenobu

“…To analyze the effects of factors on aqueous humor proinflammatory cytokine and growth factor levels in patients with uveitic glaucoma (UG). In this…”
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Intra‐ocular pressure‐lowering effects of a Rho kinase inhibitor, ripasudil (K‐115), over 24 hours in primary open‐angle glaucoma and ocular hypertension: a randomized, open‐label, crossover study by Tanihara, Hidenobu, Inoue, Toshihiro, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Abe, Haruki, Suganami, Hideki, Araie, Makoto

“…Purpose To investigate the intra‐ocular pressure (IOP)‐lowering effects of a selective Rho kinase inhibitor, ripasudil (K‐115), over 24 hr in patients with…”
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YAP/TAZ Are Essential for TGF-β2-Mediated Conjunctival Fibrosis by Futakuchi, Akiko, Inoue, Toshihiro, Wei, Fan-Yan, Inoue-Mochita, Miyuki, Fujimoto, Tomokazu, Tomizawa, Kazuhito, Tanihara, Hidenobu

“…To investigate the roles of Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ), the major effector molecules of the Hippo…”
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Suberoylanilide hydroxamic acid (SAHA) inhibits transforming growth factor-beta 2-induced increases in aqueous humor outflow resistance by Fujimoto, Tomokazu, Inoue-Mochita, Miyuki, Iraha, Satoshi, Tanihara, Hidenobu, Inoue, Toshihiro

“…Transforming growth factor-beta 2 (TGF-β2) is highly concentrated in the aqueous humor of primary open-angle glaucoma patients. TGF-β2 causes fibrosis of…”
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In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS by Takihara, Yuji, Inatani, Masaru, Eto, Kei, Inoue, Toshihiro, Kreymerman, Alexander, Miyake, Seiji, Ueno, Shinji, Nagaya, Masatoshi, Nakanishi, Ayami, Iwao, Keiichiro, Takamura, Yoshihiro, Sakamoto, Hirotaka, Satoh, Keita, Kondo, Mineo, Sakamoto, Tatsuya, Goldberg, Jeffrey L., Nabekura, Junichi, Tanihara, Hidenobu

“…The lack of intravital imaging of axonal transport of mitochondria in the mammalian CNS precludes characterization of the dynamics of axonal transport of…”
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RhoA Activation Decreases Phagocytosis of Trabecular Meshwork Cells by Fujimoto, Tomokazu, Sato-Ohira, Saori, Tanihara, Hidenobu, Inoue, Toshihiro

“…RhoA signaling is important for the regulation of intraocular pressure through the trabecular meshwork (TM). However, the relationship between RhoA signaling…”
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Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study by Tanihara, Hidenobu, Kakuda, Takahiko, Sano, Tetsuro, Kanno, Takashi, Gunji, Ryoji

“…Ripasudil is approved in Japan for glaucoma or ocular hypertension (OH) when other treatments are ineffective or cannot be administered. Its long-term safety…”
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Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation by Iraha, Satoshi, Tu, Hung-Ya, Yamasaki, Suguru, Kagawa, Takahiro, Goto, Motohito, Takahashi, Riichi, Watanabe, Takehito, Sugita, Sunao, Yonemura, Shigenobu, Sunagawa, Genshiro A., Matsuyama, Take, Fujii, Momo, Kuwahara, Atsushi, Kishino, Akiyoshi, Koide, Naoshi, Eiraku, Mototsugu, Tanihara, Hidenobu, Takahashi, Masayo, Mandai, Michiko

“…Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies…”
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Factors associated with the surgical outcomes of Baerveldt glaucoma implant for open-angle glaucoma, an age-related eye disease by Iraha, Satoshi, Takihara, Yuji, Urahashi, Yui, Watanabe, Takahiro, Nakamura, Kenichi, Urahashi, Mai, Watanabe-Kitamura, Fumika, Nakashima, Kei-Ichi, Takahashi, Eri, Kojima, Sachi, Tanihara, Hidenobu, Inoue, Toshihiro

“…To identify the factors associated with the surgical outcomes of Baerveldt glaucoma implant (BGI) for open-angle glaucoma (OAG), the medical records of 51…”
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The effects of ripasudil (K-115), a Rho kinase inhibitor, on activation of human conjunctival fibroblasts by Futakuchi, Akiko, Inoue, Toshihiro, Fujimoto, Tomokazu, Inoue-Mochita, Miyuki, Kawai, Motofumi, Tanihara, Hidenobu

“…The most common cause of glaucoma surgery failure is scar formation induced by activation of wound-healing responses and resultant fibrosis at the surgical…”
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Success Rates of Trabeculotomy for Steroid-Induced Glaucoma: A Comparative, Multicenter, Retrospective Cohort Study by Iwao, Keiichiro, Inatani, Masaru, Tanihara, Hidenobu

“…Purpose To evaluate the surgical outcomes of trabeculotomy for steroid-induced glaucoma. Design Multicenter, retrospective cohort study. Methods At 17 Japanese…”
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TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness by Matsumura, Tomoyo, Fujimoto, Tomokazu, Futakuchi, Akiko, Takihara, Yuji, Watanabe-Kitamura, Fumika, Takahashi, Eri, Inoue-Mochita, Miyuki, Tanihara, Hidenobu, Inoue, Toshihiro

“…This study aimed to investigate the effects of substratum stiffness on the sensitivity of human conjunctival fibroblasts to transforming growth factor (TGF)-β,…”
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Efficacy and safety of SNJ‐1656 in primary open‐angle glaucoma or ocular hypertension by Inoue, Toshihiro, Tanihara, Hidenobu, Tokushige, Hideki, Araie, Makoto

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Changes in Surgical Therapy for Glaucoma by Tanihara, Hidenobu

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Merlin Regulates Epithelial-to-Mesenchymal Transition of ARPE-19 Cells via TAK1-p38MAPK-Mediated Activation by Takahashi, Eri, Haga, Akira, Tanihara, Hidenobu

“…The purpose of this study was to investigate the function of merlin, which is a binding partner of the hyaluronan receptor CD44, during the…”
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