Effect of Silicon Nitride Coating on Titanium Surface: Biocompatibility and Antibacterial Properties

In recent years, with the advent of a super-aged society, lifelong dental care has gained increasing emphasis, and implant therapy for patients with an edentulous jaw has become a significant option. However, for implant therapy to be suitable for elderly patients with reduced regenerative and immun...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 17; p. 9148
Main Authors:	Tani, Akina, Tsubouchi, Harumitsu, Ma, Lin, Taniguchi, Yurie, Kobayashi, Yasuyuki, Nakai, Mariko, Komasa, Satoshi, Hashimoto, Yoshiya
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-09-2024
Subjects:	Adsorption Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial material Bacteria Biocompatibility Biofilms Bone marrow Bone Marrow Cells - drug effects Cell adhesion & migration Cell Adhesion - drug effects Cell Differentiation - drug effects Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Contact angle Cytotoxicity Dental implants Gene expression Gum disease Heat resistance implant Materials Testing Morphology Nitrogen Plasma Proteins Rats Silicon Compounds - chemistry Silicon Compounds - pharmacology Silicon nitride Staphylococcus aureus - drug effects Surface Properties Titanium Titanium - chemistry Titanium - pharmacology antibacterial material silicon nitride implant biocompatibility titanium
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Summary:	In recent years, with the advent of a super-aged society, lifelong dental care has gained increasing emphasis, and implant therapy for patients with an edentulous jaw has become a significant option. However, for implant therapy to be suitable for elderly patients with reduced regenerative and immunological capabilities, higher osteoconductive and antimicrobial properties are required on the implant surfaces. Silicon nitride, a non-oxide ceramic known for its excellent mechanical properties and biocompatibility, has demonstrated high potential for inducing hard tissue differentiation and exhibiting antibacterial properties. In this study, silicon nitride was deposited on pure titanium metal surfaces and evaluated for its biocompatibility and antibacterial properties. The findings indicate that silicon nitride improves the hydrophilicity of the material surface, enhancing the initial adhesion of rat bone marrow cells and promoting hard tissue differentiation. Additionally, the antibacterial properties were assessed using Staphylococcus aureus, revealing that the silicon nitride-coated surfaces exhibited significant antibacterial activity. Importantly, no cytotoxicity was observed, suggesting that silicon nitride-coated titanium could serve as a novel implant material.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1661-6596 1422-0067 1422-0067
DOI:	10.3390/ijms25179148