Neurite Outgrowth and Neuroprotective Effects of Quercetin from Caesalpinia mimosoides Lamk. on Cultured P19-Derived Neurons

Neurite Outgrowth and Neuroprotective Effects of Quercetin from Caesalpinia mimosoides Lamk. on Cultured P19-Derived Neurons

Quercetin has been isolated for the first time from ethyl acetate extract of Caesalpinia mimosoides Lamk. C. mimosoides Lamk. (Fabaceae) or Cha rueat (Thai name) is an indigenous plant found in mixed deciduous forest in northern and north-eastern parts of Thailand. Thai rural people consume its youn...

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Published in:Evidence-based complementary and alternative medicine Vol. 2013; no. 2013; pp. 1 - 7
Main Authors: Tangsaengvit, Napat, Kitphati, Worawan, Tadtong, Sarin, Bunyapraphatsara, Nuntavan, Nukoolkarn, Veena
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Puplishing Corporation 01-01-2013
Hindawi Publishing Corporation
Hindawi Limited
Subjects:
Acetic acid
Acetylcholinesterase
Antioxidants
Apoptosis
Ascorbic acid
Axonogenesis
Brain research
Caesalpinia
Cell growth
Deciduous forests
Disease
Drug development
Enzymes
Ethyl acetate
Fabaceae
Indigenous plants
Leaves
Medical research
Medical treatment
Neuroblastoma
Neurons
Neuroprotection
Oxidative stress
Pharmaceuticals
Pharmacy
Quercetin
Shoots
Vitamin E
Thailand
United States > US
India
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Summary:Quercetin has been isolated for the first time from ethyl acetate extract of Caesalpinia mimosoides Lamk. C. mimosoides Lamk. (Fabaceae) or Cha rueat (Thai name) is an indigenous plant found in mixed deciduous forest in northern and north-eastern parts of Thailand. Thai rural people consume its young shoots and leaves as a fresh vegetable, as well as it is used for medicinal purposes.The antioxidant capacity in terms of radical scavenging activity of quercetin was determined as IC50 of 3.18 ± 0.07 µg/mL, which was higher than that of Trolox and ascorbic acid (12.54 ± 0.89 and 10.52 ± 0.48 µg/mL, resp.). The suppressive effect of quercetin on both purified and cellular acetylcholinesterase (AChE) enzymes was investigated as IC50 56.84 ± 2.64 and 36.60 ± 2.78 µg/mL, respectively. In order to further investigate the protective ability of quercetin on neuronal cells, P19-derived neurons were used as a neuronal model in this study. As a result, quercetin at a very low dose of 1 nM enhanced survival and induced neurite outgrowth of P19-derived neurons. Furthermore, this flavonoid also possessed significant protection against oxidative stress induced by serum deprivation. Altogether, these findings suggest that quercetin is a multifunctional compound and promising valuable drugs candidate for the treatment of neurodegenerative disease.
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Academic Editor: Weena Jiratchariyakul
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/838051