Search Results - "Tangirala, Raghuram"

Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17) by Blass, Benjamin E., Iyer, Pravin, Abou-Gharbia, Magid, Childers, Wayne E., Gordon, John C., Ramanjulu, Mercy, Morton, George, Arumugam, Premkumar, Boruwa, Joshodeep, Ellingboe, John, Mitra, Sayan, Reddy Nimmareddy, Rajashekar, Paliwal, Shalini, Rajasekhar, Jamallamudi, Shivakumar, Savithiri, Srivastava, Pratima, Tangirala, Raghuram S., Venkataramanaiah, Konda, Bobbala, Ramreddy, Yanamandra, Mahesh, Krishnakanth Reddy, L.

“…[Display omitted] •Cyp17 (17α-hydroxylase-17,20-lyase) is a validated prostate cancer target.•Novel stilbenes disclosed herein are potent, selective inhibitors…”
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Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1 by Cheung, Mui, Tangirala, Raghuram S, Bethi, Sridhar R, Joshi, Hemant V, Ariazi, Jennifer L, Tirunagaru, Vijaya G, Kumar, Sanjay

“…Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays an important role in triglyceride synthesis and is a target of interest for the treatment of metabolic…”
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Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome by Blass, Benjamin E., Iyer, Pravin, Abou-Gharbia, Magid, Childers, Wayne E., Gordon, John C., Ramanjulu, Mercy, Morton, George, Arumugam, Premkumar, Boruwa, Joshodeep, Ellingboe, John, Mitra, Sayan, Nimmareddy, Rajashekar Reddy, Paliwal, Shalini, Rajasekhar, Jamallamudi, Shivakumar, Savithiri, Srivastava, Pratima, Tangirala, Raghuram S., Venkataramanaiah, Konda, Yanamandra, Mahesh

“…[Display omitted] Metabolic Syndrome, also referred to as ‘Syndrome X’ or ‘Insulin Resistance Syndrome,’ remains a major, unmet medical need despite over…”
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1‑(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators by Chekler, Eugene L. Piatnitski, Unwalla, Rayomond, Khan, Taukeer A, Tangirala, Raghuram S, Johnson, Mark, St. Andre, Michael, Anderson, James T, Kenney, Thomas, Chiparri, Sue, McNally, Chris, Kilbourne, Edward, Thompson, Catherine, Nagpal, Sunil, Weber, Gregory, Schelling, Scott, Owens, Jane, Morris, Carl A, Powell, Dennis, Verhoest, Patrick R, Gilbert, Adam M

“…We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties…”
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Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis by Surakanti, Ramu, Sanivarapu, Sumalatha, Thulluri, Chiranjeevi, Iyer, Pravin S., Tangirala, Raghuram S., Gundla, Rambabu, Addepally, Uma, Murthy, Y. L. N., Velide, Lakshmi, Sen, Subhabrata

“…An elegant reagent‐controlled strategy has been developed for the generation of a diverse range of biologically active scaffolds from a chiral bicyclic lactam…”
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Corrigendum: Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis by Surakanti, Ramu, Sanivarapu, Sumalatha, Thulluri, Chiranjeevi, Iyer, Pravin S., Tangirala, Raghuram S., Gundla, Rambabu, Addepally, Uma, Murthy, Y. L. N., Velide, Lakshmi, Sen, Subhabrata

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Azaindolines: derisking the indoline structural alert by Piatnitski Chekler, Eugene L., Khan, Taukeer A., Mamidala, Rajanikanth, Anderson, James T., Tangirala, Raghuram S., Verhoest, Patrick R., Gilbert, Adam M.

“…4-Substitued azaindolines, which are isosteres of indolines, are useful synthetic building blocks that reduce the risk of bioactivation induced idiosyncratic…”
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601 Development of improved small molecule STING agonists suitable for systemic administration by Rogacki, Maciej, Chmielewski, Stefan, Zawadzka, Magdalena, Mazurek, Jolanta, Wnuk-Lipińska, Katarzyna, Kuś, Kamil, Gluza, Karolina, Wójcik-Jaszczyńska, Katarzyna, Poczkaj, Aleksandra, Dudek, Lukasz, Schonemann, Wojciech, Głowniak-Kwitek, Urszula, Leś, Marcin, Wronowski, Marek, Mahajan, Tushar, Kulesza, Urszula, Zastawna, Magdalena, Synak, David, Zuchowicz, Karol, Banaszak, Katarzyna, Wiatrowska, Karolina, Strojny, Izabela, Gładysz, Mirosława, Jabłońska, Justyna, Gabor-Worwa, Ewelina, Tangirala, Raghuram, Stasi, Luigi, Littlewood, Peter, Brzózka, Krzysztof, Dobrzańska, Monika

“…BackgroundStimulator of Interferon Genes (STING) is a major player in the activation of robust innate immune response leading to initiation and enhancement of…”
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Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin by Tangirala, Raghuram S., Antony, Smitha, Agama, Keli, Pommier, Yves, Anderson, Bradley D., Bevins, Robert, Curran, Dennis P.

“…Analogs of the anti-tumor agent camptothecin with both closed E-rings (lactone and ether) and open E-rings (reduced acid, hydrazide, and protected Weinreb…”
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Asymmetric total synthesis of (20 R)-homocamptothecin, substituted homocamptothecins and homosilatecans by Gabarda, Ana E, Du, Wu, Isarno, Thomas, Tangirala, Raghuram S, Curran, Dennis P

“…An efficient asymmetric synthesis of a key DE lactone pyridone intermediate in the synthesis of homocamptothecin is reported. The synthesis is scalable and…”
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Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin by Tangirala, Raghuram S., Dixon, Rachel, Yang, Danzhou, Ambrus, Attila, Antony, Smitha, Agama, Keli, Pommier, Yves, Curran, Dennis P.

“…Both enantiomers of 20-fluorocamptothecin and the racemate have been prepared by total synthesis. The ( R)-enantiomer is essentially inactive in a…”
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Abstract 1280: New generation of STING agonists: Development and characterization of a novel series of systemic immunomodulators with improved potency by Rogacki, Maciej Krzysztof, Chmielewski, Stefan, Mazurek, Jolanta, Zawadzka, Magdalena, Wnuk-Lipińska, Katarzyna, Kuś, Kamil, Wójcik-Jaszczyńska, Katarzyna, Poczkaj, Aleksandra, Dudek, Łukasz, Schonemann, Wojciech, Głowniak-Kwitek, Urszula, Leś, Marcin, Wronowski, Marek, Mahajan, Tushar, Kulesza, Urszula, Zastawna, Magdalena, Synak, David, Zuchowicz, Karol, Gluza, Karolina, Banaszak, Katarzyna, Wiatrowska, Karolina, Strojny, Izabela, Gładysz, Mirosława, Jabłońska, Justyna, Gabor-Worwa, Ewelina, Dobrzańska, Monika, Tangirala, Raghuram, Littlewood, Peter, Brzózka, Krzysztof

“…Abstract Background. Stimulator of interferon genes, known as STING, is an intracellular sensor of nucleic acids and one of key regulators in activating the…”
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Cascade radical cyclization: Application to the development of novel camptothecin analogs and a short synthesis of luotonin A and its analogs by Tangirala, Raghuram S

“…Cascade radical cyclizations have been employed in the synthesis of several novel analogs of camptothecin and luotonin A. The mild conditions of the…”
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